{"id":14107,"date":"2026-09-30T09:55:13","date_gmt":"2026-09-30T09:55:13","guid":{"rendered":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/?p=14107"},"modified":"2026-09-30T09:55:17","modified_gmt":"2026-09-30T09:55:17","slug":"mounjaro-maintenance-dose","status":"publish","type":"post","link":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/mounjaro\/mounjaro-maintenance-dose\/","title":{"rendered":"What Is the Mounjaro Maintenance Dose?"},"content":{"rendered":"\n

Last Updated:<\/strong> 30 September 2026<\/p>\n\n\n\n

How Does the Mounjaro Dosage Schedule Work?<\/h2>\n\n\n\n

The Mounjaro dosage schedule starts at 2.5 mg once weekly and rises in 2.5 mg steps, with at least four weeks at every strength.<\/strong><\/p>\n\n\n\n

Mounjaro<\/a> is a once-weekly injection licensed in the UK for weight management and for treatment of type 2 diabetes. Everyone begins at 2.5 mg if they have never taken a GLP-1medication before, whichever condition they are being treated for. If tolerated well,after four weeks, the dose moves up to 5 mg. <\/p>\n\n\n\n

From there, you can gradually increase in 2.5 mg increments, spending at least four weeks on each strength before the next step. The full Mounjaro dosage<\/a> ladder runs 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg and then 15 mg.<\/p>\n\n\n\n

Starting at the bottom of that titration ladder is deliberate. The Mounjaro prescribing information<\/a> reports side effects such as nausea, vomiting and diarrhoea happen mainly while the dose is increasing. Symptoms tend to become less frequent over time as tolerance improves. Four weeks at each strength gives your body that window to adjust to the medication.<\/p>\n\n\n\n

Why Does the Maintenance Dose Matter?<\/h2>\n\n\n\n

Your maintenance dose is the Mounjaro dose you continue taking after reaching your goal weight.<\/strong> It helps stabilise your weight while giving you time to consolidate the healthy lifestyle changes and eating habits that support long-term weight management.<\/p>\n\n\n\n

In the SURMOUNT-1 trial<\/a>, participants spent 20 weeks working up to their assigned dose. They then stayed on it for the remaining 52 weeks of the 72-week trial. Roughly three-quarters of that trial ran at one of the maintenance doses.\u00a0<\/p>\n\n\n\n

In our experience, people brace themselves for the first few months and then relax once their dose stops changing. Reaching the highest dose does not mean the work is done. Most of your weight loss still lies ahead, and your weight loss goals need the same attention at month six as they did in week one. <\/p>\n\n\n\n

Maintaining your Mounjaro weight loss<\/a> depends on building healthy habits while the medication is quietening your appetite. These will stand you in good stead in the long term, so that you can hold onto your weight loss results. A healthy, balanced diet, increased physical activity and weight-bearing exercise to protect muscle are all steps worth working towards whilst on your maintenance dose.<\/p>\n\n\n\n

What Doses of Mounjaro Can I Use for Maintenance?<\/h2>\n\n\n\n

The licensed maintenance doses are 5 mg, 10 mg and 15 mg once weekly, and 15 mg is the maximum.<\/strong> These are the doses tested in trials, with strong evidence for long-term safety and effectiveness. <\/p>\n\n\n\n

Weekly dose<\/strong><\/td>Average weight loss at 72 weeks<\/strong><\/td><\/tr>
5 mg<\/td>15.0%<\/td><\/tr>
10 mg<\/td>19.5%<\/td><\/tr>
15 mg<\/td>20.9%<\/td><\/tr>
Placebo (inactive injection)<\/td>3.1%<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Figures come from SURMOUNT-1<\/a>, which followed 2,539 adults for 72 weeks.<\/p>\n\n\n\n

An extension study followed 1,032 of the SURMOUNT-1 participants<\/a> who had prediabetes alongside obesity for three years. They continued on either 5 mg, 10 mg or 15 mg and remained approximately 12% to 20% below their starting weight at 176 weeks, with no new safety concerns.\u00a0<\/p>\n\n\n\t\t

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Save on your next Mounjaro order<\/span><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Start your assessment<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Can I Use a Lower Dose for Maintenance?<\/h2>\n\n\n\n

A lower maintenance dose of Mounjaro that you can stay on beats a higher one you are not able to take consistently.<\/strong> Skipping injections for a week or two while side effects settle down may reduce the medicine\u2019s effect and slow your progress..<\/p>\n\n\n\n

Higher doses produced more weight loss on average in the SURMOUNT-1 results. Participants lost an average of 19.5% of their body weight with 10 mg and 20.9% with 15 mg after 72 weeks. However, the difference between the two doses was relatively small, and both doses can cause side effects, particularly gastrointestinal symptoms. Our team can help you decide which dose is most appropriate based on your weight-management goals, response to treatment and how well you tolerate the medication.<\/p>\n\n\n\n

Some people can tolerate 15 mg comfortably. For others, the nausea at that dose does not settle enough to live with. Stepping down to 5 mg or 10 mg is what makes treatment sustainable. Staying on a lower dose is a perfectly good outcome.<\/p>\n\n\n\n

Is 7.5 mg Mounjaro a Maintenance Dose?<\/h3>\n\n\n\n

No, 7.5 mg is not one of the three licensed maintenance doses, though for some people it may be appropriate to remain on this strength.<\/strong><\/p>\n\n\n\n

The patient information leaflet names 5 mg, 10 mg and 15 mg as the recommended maintenance doses for adults. SURMOUNT-1 tested all three for effectiveness and safety.<\/p>\n\n\n\n

The 7.5 mg and 12.5 mg doses are considered “in between” steps. But some people do remain on 7.5 mg for long-term treatment if it is the strongest dose they can take without side effects.<\/p>\n\n\n\n

Can I Use a Maintenance Dose of Mounjaro for Weight Loss?<\/h2>\n\n\n\n

Yes.<\/strong> Weight loss can continue after you reach a licensed maintenance dose, so reaching this dose does not necessarily mean that you have reached your goal weight.<\/p>\n\n\n\n

Reaching a maintenance strength of mounjaro is not the end of your weight loss. You are still able to use a maintenance dose for weight loss. Participants in SURMOUNT-1 reached their dose at week 20, and continued to lose weight over the remaining 52 weeks.<\/p>\n\n\n\n

What you cannot do is start at a maintenance strength if you are taking no other GLP1 treatment. Everyone begins at 2.5 mg and works up from there. The risk of side effects, digestive ones especially, is highest in the weeks your dose is going up. The Mounjaro safety data<\/a> show nausea in 25% to 29% of people taking tirzepatide for weight management. Among people on placebo, the figure was 8.5%.<\/p>\n\n\n\n

Rushing up the dose ladder can backfire. If side effects at your current strength have not settled, moving up may carry symptoms into the next four weeks.<\/p>\n\n\n\n

How Do I Find the Right Treatment Dose on Mounjaro?<\/h2>\n\n\n\n

Your maintenance dose for weight loss depends on how much weight you are losing and how well you tolerate the medication.<\/strong> The prescribing information does not name one maintenance dose for everyone.<\/p>\n\n\n\n

For weight loss we aim for the lowest dose that keeps your weight dropping at a steady rate without side effects that are getting in the way of your day, and this could be one of the licensed maintenance doses. However your personal maintenance dose<\/strong> is different, it\u2019s the dose that helps you stabilise your weight after reaching your goal and this is normally lower than the one you have used for weight loss.<\/p>\n\n\n\n

If your weight has stalled and you feel well, it is reasonable to increase your dose. If side effects have not settled, waiting on your current dose is the better call.<\/p>\n\n\n\n

The Mounjaro product license also sets a review point at six months on your highest tolerated dose. If you have not lost at least 5% of your starting body weight by then, it is worth reconsidering this weight loss treatment.<\/p>\n\n\n\n

Do I Stay on My Mounjaro Maintenance Dose After Weight Loss? <\/h2>\n\n\n\n

Most people stay on a maintenance dose because stopping tends to bring the weight back. In SURMOUNT-4, people who came off tirzepatide regained 14% in their starting weight within a year. <\/strong><\/p>\n\n\n\n

The 670 SURMOUNT-4 participants<\/a> spent 36 weeks working up to Mounjaro 10 mg or 15 mg. They lost around 21% of their body weight on average. At that point, half then carried on with tirzepatide. Half switched to placebo. Neither group knew which injection they were using.<\/p>\n\n\n\n

Over the following year, the group who continued on Mounjaro lost a further 5.5% body weight. In the group that switched to placebo, weight increased by 14%. Nearly nine in ten of those who stayed on treatment held onto at least 80% of their loss. Fewer than two in ten of those who were switched to placebo managed the same.<\/p>\n\n\n\n

Mounjaro’s UK licence covers weight management, which includes both weight loss and weight maintenance. You can hit your target weight and still need a maintenance dose to help hold on to the results.<\/p>\n\n\n\n

Some people remain on the dose that supported their weight loss when they move into weight maintenance. Others may step down to a lower strength, depending on their individual needs, response and tolerability. SURMOUNT-4 only compared carrying on at the same dose against stopping altogether, so we do not know how well a reduced dose stabilises the weight. Both options are worth reviewing with us once you have reached your weight loss target.<\/p>\n\n\n\n

When Should I See a Doctor?<\/h2>\n\n\n\n

Most side effects on a maintenance dose settle on their own, though a few symptoms need attention the same day.<\/strong><\/p>\n\n\n\n

Contact our clinical team about:<\/strong><\/p>\n\n\n\n

\u2022 Nausea, vomiting, diarrhoea or constipation that you can still manage at home<\/p>\n\n\n\n

\u2022 Reflux or heartburn that started after a dose increase<\/p>\n\n\n\n

\u2022 Questions about changing your dose or pausing treatment<\/p>\n\n\n\n

Contact your GP or<\/strong> call NHS 111<\/strong><\/a> if you have:<\/strong><\/p>\n\n\n\n

\u2022 Symptoms of a possible gallbladder problem<\/a>: yellowing of your skin or eyes, or severe pain in the upper right of your stomach<\/p>\n\n\n\n

\u2022 Vomiting or diarrhoea so persistent that you cannot keep fluids down<\/p>\n\n\n\n

\u2022 Symptoms of low blood sugar, if you also take insulin or a sulfonylurea tablet<\/p>\n\n\n\n

Stop Mounjaro and<\/strong> call 999<\/strong><\/a> or go to A&E if you notice any of the following:<\/strong><\/p>\n\n\n\n

\u2022 Severe stomach pain that spreads through to your back and does not go away. This can signal pancreatitis<\/a>.<\/p>\n\n\n\n

\u2022 Swelling of your face, lips or throat, or sudden difficulty breathing<\/p>\n\n\n\n

\u2022 Signs of severe dehydration after prolonged vomiting or diarrhoea<\/p>\n\n\n\n

\u2022 Loss or blurring of vision, in one of both eyes<\/p>\n\n\n\n

If you are having thoughts of harming yourself, go to A&E and ask for the CRISIS team.<\/p>\n\n\n\n

Key Takeaways<\/h2>\n\n\n\n

\u2022 Mounjaro’s licensed maintenance doses are 5 mg, 10 mg and 15 mg once weekly, with 15 mg the maximum.<\/p>\n\n\n\n

\u2022 Average weight loss on 15 mg reached just under 21% over 72 weeks in SURMOUNT-1.<\/p>\n\n\n\n

\u2022 The best maintenance dose for you during the treatment phase: the highest strength you can tolerate without side effects that disrupt your day to day.<\/p>\n\n\n\n

\u2022 If you come off Mounjaro treatment after you have reached your target weight, you should expect some weight regain. Weight rose by 14% within a year among SURMOUNT-4 participants who switched to placebo.<\/p>\n\n\n\n

References<\/h2>\n\n\n\n

Mounjaro KwikPen 10 mg solution for injection in pre-filled pen<\/em><\/a>, electronic medicines compendium, 2026 [Accessed 20 August 2026].<\/p>\n\n\n\n

Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)<\/em><\/a>, New England Journal of Medicine, 2022 [Accessed 20 August 2026].<\/p>\n\n\n\n

Tirzepatide for Obesity Treatment and Diabetes Prevention (SURMOUNT-1 three-year results)<\/em><\/a>, New England Journal of Medicine, 2025 [Accessed 20 August 2026].\u00a0<\/p>\n\n\n\n

Continued Treatment With Tirzepatide for Maintenance of Weight Reduction in Adults With Obesity (SURMOUNT-4)<\/em><\/a>, JAMA, 2024 [Accessed 20 August 2026].<\/p>\n\n\n\n

Tirzepatide: a medicine to manage type 2 diabetes and treat obesity<\/em><\/a>, NHS [Accessed 20 August 2026].<\/p>\n\n\n\n

GLP-1 receptor agonists and dual GLP-1\/GIP receptor agonists: strengthened warnings on acute pancreatitis<\/em><\/a>, GOV.UK Drug Safety Update, 2026 [Accessed 20 August 2026].<\/p>\n\n\n\n

Authorship<\/h3>\n\n\n\t\t
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\"Shereen<\/a><\/figure>

Authored by Shereen Amin<\/h4><\/a><\/h4>

Pharmacist Independent Prescriber & Medical Writer\n
GPhC: 2073003<\/a><\/b>\n
\nShereen is a Pharmacist Independent Prescriber and medical writer with over ten years' experience across NHS primary care, digital health and specialist services. She writes evidence-based health content for Simple Online Pharmacy, turning complex clinical information into guidance patients can actually use.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\n\n\t\t

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\"Zahra<\/a><\/figure>

Medically Reviewed by Zahra Qureshi<\/h4><\/a><\/h4>

Senior Pharmacist<\/b>
\nGPhC: <\/b>2216331<\/a><\/b> \n
\nZahra began her pharmacy career in community pharmacy, building a strong foundation in patient care and medication safety. She joined Simple Online Pharmacy as a locum pharmacist and quickly progressed to a senior role, supporting the pharmacy and operations teams. Zahra is passionate about ensuring patient guidance is safe, clinically sound, and easy to understand, making a positive difference to patients\u2019 lives.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Mounjaro has three licensed maintenance doses: 5 mg, 10 mg and 15 mg, which are taken once weekly. The best maintenance dose for you is the one you can tolerate and take consistently to maintain your weight loss.<\/p>\n","protected":false},"author":41,"featured_media":19650,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[99],"tags":[213,28],"treatments":[],"class_list":["post-14107","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-mounjaro","tag-weekly-lilly-mounja","tag-weight-loss-injections"],"yoast_head":"\nMounjaro Maintenance Dose Explained | Simple Online Pharmacy<\/title>\n<meta name=\"description\" content=\"Find out how Mounjaro maintenance dosing works, which doses are licensed, and what to consider when staying on treatment.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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