{"id":14721,"date":"2025-06-04T10:11:27","date_gmt":"2025-06-04T10:11:27","guid":{"rendered":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/?p=14721"},"modified":"2025-09-17T10:35:11","modified_gmt":"2025-09-17T10:35:11","slug":"does-mounjaro-make-you-cold","status":"publish","type":"post","link":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/mounjaro\/does-mounjaro-make-you-cold\/","title":{"rendered":"Does Mounjaro Make You Cold?"},"content":{"rendered":"\n

Updated 24\/06\/2025<\/em><\/p>\n\n\n\n

If you’re using Mounjaro, you’re probably experiencing some changes, including steady weight loss and a smaller appetite. But maybe you’ve also noticed that you\u2019re colder than usual, particularly in your hands and feet.<\/p>\n\n\n\n

It\u2019s not just you. A lot of users have reported feeling a bit chillier than usual. But it’s not listed among the common side effects of Mounjaro<\/a>.<\/p>\n\n\n\n

So could Mounjaro be making you cold? Here, you\u2019ll learn why it happens and how you can manage it.<\/p>\n\n\n\n

Is Feeling Cold a Side Effect of Mounjaro?<\/h2>\n\n\n\n

Feeling cold isn\u2019t listed as a side effect of Mounjaro (tirzepatide)<\/a> on the medication\u2019s patient information leaflet<\/a>. But that doesn\u2019t mean there isn\u2019t a link between the two.<\/p>\n\n\n\n

While not listed among Mounjaro\u2019s side effects, including nausea, constipation, and fatigue, many patients report feeling colder than usual. Especially in their hands and feet. So if this sounds familiar, you\u2019re not alone.<\/p>\n\n\n\n

However, it\u2019s possible that changes Mounjaro causes in your body \u2013 including a reduced appetite and weight loss \u2013 are leading you to feel cold.<\/p>\n\n\n\n

In most cases, feeling cold on Mounjaro is not dangerous. You should return to a comfortable temperature as your body adjusts to your treatment and changes in your lifestyle.<\/p>\n\n\n\n

But it can be uncomfortable. If the cold is affecting your daily life, knowing why it\u2019s happening and how to manage it can make weight loss easier.<\/p>\n\n\n\n

Why Does Mounjaro Make You Cold?<\/h2>\n\n\n\n

There are a few reasons why you might feel colder while using Mounjaro. The medication itself is probably not the main cause of it. Instead, it\u2019s more likely that weight loss and eating less on Mounjaro is causing your body temperature to drop.<\/p>\n\n\n\n

Less Body Fat Means Less Insulation<\/h3>\n\n\n\n

Fat acts as insulation<\/a>. The fat that sits just under the skin, known as subcutaneous fat, helps trap heat and protect your body from cold environments.<\/p>\n\n\n\n

As you lose fat through diet, exercise or medication like Mounjaro, you also lose some of that protective layer. Simply put, your body has less padding to keep warmth in. That can leave you feeling cold.<\/p>\n\n\n\n

If you\u2019ve lost weight rapidly, you may notice the temperature difference even more. Feeling cold could be a sign that you\u2019re losing too much body weight, too quickly. Aim for steady weight loss of 1-2 lbs per week.<\/p>\n\n\n\n

Reduced Food Intake<\/h3>\n\n\n\n

Calories in food give you energy to move and keep your body warm. When you consume fewer calories, your body produces less heat<\/a>.<\/p>\n\n\n\n

Mounjaro works by mimicking two hormones that help regulate your appetite: glucagon-like peptide 1 (GLP-1) and gastric inhibitory polypeptide (GIP). This action suppresses your appetite, which means your food intake will likely decrease.<\/p>\n\n\n\n

Feeling cold may be more noticeable when your intake drops significantly. This is usually during the first few weeks of using Mounjaro weight loss injections. While eating less is normal, make sure you\u2019re not eating too little<\/a> by planning regular meals made up of nutrient-dense whole foods.<\/p>\n\n\n\n

Metabolism Slows During Weight Loss<\/h3>\n\n\n\n

As you lose weight, your metabolic rate may slow down<\/a>. This means your body burns energy slower as a way to conserve fuel. Losing muscle mass, which can happen with weight loss, can also contribute to a slower metabolism.<\/p>\n\n\n\n

This is a natural response to losing weight. But when your metabolism slows down, your body produces less heat. That can leave you feeling cold more often, especially when you\u2019re resting.<\/p>\n\n\n\n

Possible Nutrient Deficiencies<\/h3>\n\n\n\n

In some cases, weight loss or diet changes can impact how many nutrients you\u2019re eating and how well your body absorbs them<\/a>. This may impact body temperature.<\/p>\n\n\n\n

If you’re low in iron or vitamin B12, you might feel colder than usual. These deficiencies can appear during periods of calorie restriction or if your diet becomes more limited. For example, if you\u2019re skipping meals or cutting out food groups.<\/p>\n\n\n\n

Your doctor can arrange a simple blood test to identify deficiencies and provide treatment, which should improve your symptoms.<\/p>\n\n\n\n

Eating a variety of nutritious whole foods is the best way to get enough nutrients. But you might want to consider adding a supplement<\/a>, where you\u2019re finding it hard to meet certain requirements.<\/p>\n\n\n\n

Mounjaro Could Affect \u201cBrown Fat\u201d<\/h3>\n\n\n\n

Some research suggests that GLP-1 receptor agonists, like Mounjaro, might affect how your body uses a type of fat that keeps you warm<\/a>. This fat, called brown fat or brown adipose tissue (BAT), burns calories to make heat (called thermogenesis).<\/p>\n\n\n\n

Because Mounjaro may <\/em>impact BAT, the fat might not be doing its job as well. So you might feel colder than usual.<\/p>\n\n\n\n

Scientists are still learning how these medications impact brown fat activity. But it’s another possible reason some people using Mounjaro may feel cold sensitivity.<\/p>\n\n\n\n

Why Hands and Feet Get the Coldest<\/h2>\n\n\n\n

When you are cold, circulation to your hands, feet, ears and nose (your extremities) reduces.<\/p>\n\n\n\n

This is because your body is designed to protect your vital organs, including the heart, lungs and brain. When it detects cold, it prioritises warming these essential areas over hands and feet.<\/p>\n\n\n\n

Cold hands and feet can be even more noticeable if you\u2019ve lost a lot of weight or are eating too little.<\/p>\n\n\n\n

How Long Will I Feel Cold on Mounjaro?<\/h2>\n\n\n\n

It\u2019s not clear how long you might feel cold on Mounjaro, since it\u2019s not an official side effect. But it\u2019s likely you\u2019ll start feeling less cold once your weight levels out.<\/p>\n\n\n\n

As your body adjusts to your weight loss, your metabolism should gradually pick up again. This will help your body generate heat, which will reduce cold sensitivity. Particularly if you\u2019re no longer in a calorie deficit or actively losing fat.<\/p>\n\n\n\n

For some, feeling cold may come and go depending on changes in diet, weight or even the weather. While it can be uncomfortable, it’s often part of your body adapting to new patterns. For many, it becomes more manageable with time and lifestyle changes.<\/p>\n\n\n\n

How to Manage Feeling Cold on Mounjaro<\/h2>\n\n\n\n

You should start feeling less cold as your body weight stabilises. But if feeling cold is getting to you, here are some simple, effective ways to feel warmer and more comfortable:<\/p>\n\n\n\n