{"id":16659,"date":"2025-09-12T11:29:44","date_gmt":"2025-09-12T11:29:44","guid":{"rendered":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/?p=16659"},"modified":"2026-06-12T12:20:19","modified_gmt":"2026-06-12T12:20:19","slug":"wegovy-side-effects","status":"publish","type":"post","link":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/wegovy\/wegovy-side-effects\/","title":{"rendered":"Wegovy Side Effects: A Complete Guide"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">While most users tolerate it well, <a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/online-doctor\/weight-loss\/wegovy\/\">Wegovy (semaglutide)<\/a> has some side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The most common ones will be fairly mild. They should improve over time, as you get used to your new medication. And some small tweaks to your lifestyle will help you manage them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Like most drugs, there is a risk of more serious effects too. And it\u2019s important you know the risks before you start the treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this guide, you\u2019ll learn the side effects of the Wegovy injection \u2013 from the most common to rarer side effects. And we\u2019ll give you some tips for managing side effects. So you can make your weight management journey as comfortable as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-are-the-common-side-effects-of-wegovy\">What Are the Common Side Effects of Wegovy?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Very common<\/strong><strong><br><\/strong><strong>(<\/strong>may affect more than 1 in 10 people), are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Headache<\/li>\n\n\n\n<li>Feeling sick (nausea)<\/li>\n\n\n\n<li>Being sick (vomiting)<\/li>\n\n\n\n<li>Diarrhoea<\/li>\n\n\n\n<li>Constipation<\/li>\n\n\n\n<li>Stomach pain<\/li>\n\n\n\n<li>Feeling weak or tired<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Common<\/strong><strong><br><\/strong>(may affect up to 1 in 10 people), are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Feeling dizzy<\/li>\n\n\n\n<li>Upset stomach or indigestion<\/li>\n\n\n\n<li>Burping<\/li>\n\n\n\n<li>Gas (flatulence)<\/li>\n\n\n\n<li>Bloating of the stomach<\/li>\n\n\n\n<li>Inflamed stomach (\u2018gastritis\u2019) \u2013 the signs include stomach ache, feeling sick (nausea) or being sick (vomiting)<\/li>\n\n\n\n<li>Reflux or heartburn \u2013 also known as gastro-oesophageal reflux disease (GERD)<\/li>\n\n\n\n<li>Gallstones<\/li>\n\n\n\n<li>Hair loss<\/li>\n\n\n\n<li>Injection site reactions<\/li>\n\n\n\n<li>Change in the way food or drink tastes<\/li>\n\n\n\n<li>Change in skin sensation<\/li>\n\n\n\n<li>Low blood sugar or diabetic retinopathy in patients with type 2 diabetes<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-does-wegovy-make-you-tired\">Does Wegovy Make You Tired?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes, <a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/wegovy\/does-wegovy-make-you-tired\/\">Wegovy can make you tired<\/a>. The patient information leaflet lists it as a common side effect of the medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Experts aren\u2019t sure exactly <em>why <\/em>it can make you tired. But it could be for a number of reasons:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>You\u2019re Not Eating As Much:<\/strong> Wegovy suppresses your appetite. So you\u2019re probably eating less food than before. If you\u2019re not getting enough nutrients from whole foods, your energy levels may dip.<\/li>\n\n\n\n<li><strong>Side Effects Are Making You Tired:<\/strong> Common ones, like diarrhoea, nausea and vomiting can make you feel fatigued.<\/li>\n\n\n\n<li><strong>Wegovy May Affect Your Hormones: <\/strong>Wegovy works by mimicking certain hormones responsible for regulating blood sugar and appetite. It\u2019s possible these metabolic changes might leave you feeling drained.<\/li>\n\n\n\n<li><strong>The Treatment May Impact Your Sleep-Cycle: <\/strong>It is possible that Wegovy is impacting your sleep-wake cycle. The area of your brain that regulates appetite also regulates sleep.<\/li>\n\n\n\n<li><strong>Your Blood Sugar is Low:<\/strong> While uncommon, low blood sugar is a side effect of Wegovy. Low blood sugar can cause fatigue.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-can-wegovy-cause-headaches\">Can Wegovy Cause Headaches?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes. Wegovy can cause headaches. And it\u2019s an official side effect of the medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you\u2019re experiencing headaches on Wegovy, it could be down to a number of factors. A common cause is dehydration, because you&#8217;ll likely be eating and drinking less during treatment. Side effects, like diarrhoea and vomiting, also cause you to lose fluids.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A number of other factors (alcohol, sleep and stress) can also cause headaches. So drink enough water (aim for 2-3l per day) and get plenty of sleep. Some fresh air and doing some gentle exercise can also make a difference.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-does-wegovy-cause-heartburn\">Does Wegovy Cause Heartburn?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes, Wegovy can cause heartburn (AKA acid reflux).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is because, on Wegovy, food moves slower through the digestive system and stays in your stomach longer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While this helps you get full quicker (and stay fuller for longer), you might experience some acid reflux too.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Head to the section below for tips on how to manage it.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-wegovy-and-stomach-pain\">Wegovy and Stomach Pain<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Stomach pain is one of the most common side effects of Wegovy. Because Wegovy slows down the digestive system, your risk of abdominal pain and discomfort increases.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See a doctor immediately if stomach pain is severe. It could be a sign of acute pancreatitis (an inflamed pancreas). The pain may last a long time and it may move to your back.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Pain in the back or lower abdomen might also be a sign of kidney or bladder stones. With kidney stones, peeing can be difficult. And you might notice a change in the colour of your urine.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-wegovy-and-diarrhoea\">Wegovy and Diarrhoea<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Diarrhoea is one of the most common side effects of Wegovy.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The medication works because it slows down the rate at which food leaves the stomach. This slowing down of the digestive system can increase your risk of stomach-related side effects. For some patients, this causes diarrhoea.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The diarrhoea should subside once your body adapts to the medication. The most important thing is to drink enough water, because diarrhoea causes you to lose fluids.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Head to the section below for tips on how to manage diarrhoea.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-can-wegovy-cause-hair-loss\">Can Wegovy Cause Hair Loss?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes, Wegovy can cause hair loss and the patient information leaflet lists it as a side effect. But it\u2019s likely an indirect cause of the medication. No strong research suggests it\u2019s caused by Wegovy itself.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Losing weight too quickly or not getting all the nutrients you need through your diet could be causing your hair loss. Your body may respond by slowing down non-essential processes, like hair growth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This type of hair loss (called telogen effluvium) is temporary. It should improve when you start eating a nutrient-rich diet. Make sure your diet is healthy and balanced and that you\u2019re eating enough food. Aim for steady weight loss of 1-2 lb per week.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-does-wegovy-cause-vaginal-dryness\">Does Wegovy Cause Vaginal Dryness?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Some users have reported that Wegovy causes vaginal dryness.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Vaginal dryness is not an official side effect of the medication. And there\u2019s no evidence that medication causes it. But it\u2019s possible that changes caused by Wegovy can impact vaginal health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Changes in your hormone levels cause vaginal dryness. Certain things, like the menopause, breastfeeding and taking some medications, can impact your hormones \u2013 leading to vaginal dryness. Rapid weight loss or dietary changes can also influence hormone levels.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It could also be a side effect of side effects. Some stomach-related side effects, like vomiting, diarrhoea, constipation, can also impact the gut. This can lead to vaginal dryness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-uncommon-side-effects-of-wegovy\">Uncommon Side Effects of Wegovy<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Uncommon side effects<\/strong><br>(which may affect up to 1 in 100 people) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Increased heart rate<\/li>\n\n\n\n<li>An increase of pancreatic enzymes (such as lipase and amylase) shown in blood tests&nbsp;<\/li>\n\n\n\n<li>Low blood sugar<\/li>\n\n\n\n<li>Increased levels of bilirubin in your blood. Signs include jaundice (the yellowing of the skin or the whites of your eyes)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-when-do-wegovy-side-effects-start\">When Do Wegovy Side Effects Start?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Most patients experience common side effects when they start using Wegovy and when they increase their dose. But you should feel them less as your body adapts to the dose.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wegovy reaches peak concentration two to three days after injecting it. So you might find side effects get worse when it reaches these levels.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-long-do-wegovy-side-effects-last\">How Long Do Wegovy Side Effects Last?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">How long side effects last will vary from person to person. In many cases, they\u2019ll improve as your body gets used to the medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Most people notice they settle down within a few days of starting Wegovy or moving to a higher dose.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But in rarer cases, your body might not build that tolerance. That means with each injection, as the drug builds up in your system, side effects could get worse. If that happens, reach out to your Wegovy provider for advice.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-how-long-does-wegovy-stay-in-your-system\">How Long Does Wegovy Stay in Your System?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">It can help to understand how long Wegovy stays in your system. You can get a better idea of when side effects will be at their worst and when to expect them to improve.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wegovy has a <strong>half-life of seven days<\/strong>. So the amount of semaglutide (the active ingredient) halves in your body in one week. That\u2019s why it\u2019s a once-weekly injection \u2013 so it stays at a steady level in your body.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The medication stays in your system for around five to seven weeks after your last dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-can-i-reduce-the-side-effects-of-wegovy\">How Can I Reduce the Side Effects of Wegovy?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The best strategy will depend on the specific side effect. Different methods can help you lessen different types of discomfort.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, for a lot of the common side effects, you can reduce them by:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Drinking lots of water \u2013 aim for 2-3l a day<\/li>\n\n\n\n<li>Doing light exercise<\/li>\n\n\n\n<li>Eating regularly<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-managing-stomach-related-side-effects\">Managing Stomach-Related Side Effects<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-heartburn\">Heartburn<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">We recommend you make dietary and lifestyle changes to manage heartburn. Here are a few things you can reduce irritation and improve comfort:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Increase Your Water Intake:<\/strong> This can include herbal teas. And even food that contains lots of water (think celery, broth and melon).<\/li>\n\n\n\n<li><strong>Limit Certain Foods and Alcohol: <\/strong>Foods that may<strong> <\/strong>trigger heartburn include foods high in citrus, caffeine, and spicy or highly fatty meals. And avoid alcohol as this can worsen heartburn.<\/li>\n\n\n\n<li><strong>Time Your Meals:<\/strong> Do you normally eat three big meals every day? Try eating smaller meals and snacks spread throughout the day. Avoid lying down for around two hours after a meal.<\/li>\n\n\n\n<li><strong>Avoid Smoking:<\/strong> This includes vaping. Both smoking and vaping cause acids to travel up your digestive tract, which can cause acid reflux.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If lifestyle changes alone aren\u2019t helping, medications can help. We\u2019d usually recommend a treatment like Nexium. It offers protective support for your stomach and is available in 14-day courses for longer-term relief.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, for faster-acting, short-term relief, Tums, Rolaids, Gaviscon, and Rennies can help. These treatments, called antacids, work by neutralising stomach acid. Most local pharmacies stock these over the counter. Your local pharmacist can advise on the most suitable option for you.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If your acid reflux persists or worsens, get in contact with us or your GP for further advice.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-diarrhoea\">Diarrhoea<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">When managing symptoms of diarrhoea, these small steps you can make a big difference:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Drink More Water.<\/strong> Diarrhoea can cause dehydration. Drinking enough water, diluted fruit juice and rehydration drinks (Dioralyte) can help replace lost fluids.<\/li>\n\n\n\n<li><strong>Eat Bland, Digestible Foods: <\/strong>Think BRAT (bananas, rice, applesauce and toast). Plain boiled potatoes, crackers and oatmeal are easy to digest too. You should only do this for a couple days.<\/li>\n\n\n\n<li><strong>Limit Certain Foods and Drinks: <\/strong>Like fatty, fried and spicy foods. High-fibre foods can also make diarrhoea worse. Avoid dairy products if you\u2019re lactose intolerant. Coffee, sugary drinks and alcohol can worsen dehydration.<\/li>\n\n\n\n<li><strong>Do Light Exercise (or Housework):<\/strong> Movement increases the flow of blood to your digestive system. This can improve symptoms. If walking and cycling is too intense, try some light housework or gardening. Yoga is another gentle form of movement that stimulates your digestive system.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Over-the-counter medications such as loperamide (Imodium) can also help manage symptoms. However, only use this medication for a short period. If diarrhoea symptoms don\u2019t improve, or get worse, contact us or your GP for advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-feeling-sick-on-wegovy\">Feeling Sick on Wegovy<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Nausea is a common side effect of the medication \u2013 and it should eventually pass. But there are a few steps you can take to <a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/wegovy\/stop-feeling-sick-wegovy\/\">stop feeling sick on Wegovy<\/a>:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Opt for Smaller Meals. <\/strong>Eating little and often can help you feel less sick. Try eating five to six small meals and snacks. And spread them throughout the day.<\/li>\n\n\n\n<li><strong>Eat Gentle Foods and Drinks. <\/strong>Choose plain foods like rice, crackers or bananas. And avoid spicy, rich or fatty foods. Note which foods trigger the nausea and avoid them when symptoms are at their worst.<\/li>\n\n\n\n<li><strong>Drink Plenty of Water: <\/strong>This is one of the best ways to reduce nausea. Sip on water throughout the day. Drink hydrating hot drinks, like herbal tea, between meals.<\/li>\n\n\n\n<li><strong>Take a Brisk Walk: <\/strong>Not only will walking outside help clear your head, and the fresh air can improve stomach symptoms.<\/li>\n\n\n\n<li><strong>Eat (and Drink) Ginger:<\/strong> Ginger has been proven to settle your stomach, thanks to gingerol, its main component. Bonus: ginger tea or non-alcoholic ginger drinks also<em> <\/em>help you stay hydrated.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If you\u2019re still feeling nauseous, you could also try anti-sickness medication. However, this should only be a short-term solution. Please let us know if you\u2019re struggling with nausea. Our team can advise you on suitable anti-nausea medication and offer advice tailored to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-do-i-need-to-avoid-certain-foods\">Do I Need to Avoid Certain Foods?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">On Wegovy, we encourage you to eat a healthy diet. This means <em>adding<\/em> <em>more <\/em>whole foods to your diet: fruits, veg, whole grains, lean meat and healthy fats. But what about foods to avoid on the medication?<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">You don\u2019t need to follow strict diet rules or cut out favourites completely. Burgers, pizza and ice cream can still be part of a healthy, balanced diet. But mindful eating is important here. When you pay attention to how you feel when you eat, you\u2019ll find some foods may worsen side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Foods that may make side effects worse include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Greasy Foods, High in Fat:<\/strong> This can make nausea, indigestion and acid reflux worse.<\/li>\n\n\n\n<li><strong>Sugary Foods and Drinks: <\/strong>Excess sugar can also worsen nausea and bloating. This is&nbsp; especially true if you eat them on an empty stomach.<\/li>\n\n\n\n<li><strong>Ultra-Processed Foods: <\/strong>Crisps, chips and packaged foods can cause digestive upset. The high salt content can also cause you to retain fluids.<\/li>\n\n\n\n<li><strong>Refined Carbs: <\/strong>For example, white bread and pastries.<strong> <\/strong>They don\u2019t provide much fibre, which is important for healthy bowels and digestion.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-managing-injection-site-reactions\">Managing Injection Site Reactions<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Up to 1 in 10 people using weight loss injections, like Wegovy, report injection site reactions. Patients might experience redness, bruising, itching and swelling. In most cases, these symptoms subside as your body adjusts to the medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, there are some ways to manage these reactions. Here\u2019s what can help:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Take a non-drowsy oral antihistamine 30 minutes before injecting. Your local pharmacy can help you choose a suitable one.<\/li>\n\n\n\n<li>Apply an anti-itch cream, e.g. Eurax, to the affected area.<\/li>\n\n\n\n<li>Rotate injection sites each time you inject to minimise the risk of irritation. Recommended sites include the stomach, upper thigh, or upper arm.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If the reaction gets worse, spreads, becomes more painful, stop using the medication. Seek medical advice from your GP, NHS 111 or A&amp;E.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-the-serious-side-effects-of-wegovy\">The Serious Side Effects of Wegovy<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Like all medications, Wegovy has some serious side effects. They\u2019re not common, but it\u2019s important you know what they are and recognise the symptoms.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>uncommon serious side effects<\/strong>, which may affect up to 1 in 100 people, are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>An Inflamed Pancreas (Acute Pancreatitis): <\/strong>Symptoms include severe and long-lasting pain in your stomach. The pain may move to your back. You should see your doctor immediately if you experience such symptoms.&nbsp;<\/li>\n\n\n\n<li><strong>Kidney or Bladder Stones:<\/strong> Symptoms include back or lower abdomen pain. You might also have difficulty urinating or see a change in urine colour.&nbsp;<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">If you experience any of these symptoms, <strong>seek urgent medical attention<\/strong>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <strong>rare side effects of Wegovy<\/strong>, which may affect up to 1 in 1,000 people, are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Severe Allergic Reactions: <\/strong>Get medical help right away if you have trouble breathing. You might experience lumps or swelling in your face, lips, tongue, or throat. You may also have difficulty swallowing, wheezing, a fast heartbeat, pale or cold skin, and feel dizzy or weak.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Hip Fractures:<\/strong> One clinical trial found hip and pelvic fractures were reported more often in patients taking Wegovy, compared to those not taking it. However another links lower bone density with the effects of rapid weight loss, not the medicine itself. It\u2019s rare, but highlights why a balanced diet and steady, gradual weight loss are so important.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Wegovy also comes with a risk of a severe form of constipation. Additional symptoms include stomach ache, bloating and vomiting. While rare, experts don\u2019t know exactly how often this side effect occurs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-interactions-and-when-to-avoid-wegovy\">Interactions and When to Avoid Wegovy<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Some medications, supplements, and substances may interact with Wegovy or make side effects worse. And some patients may have health conditions that make Wegovy unsuitable for them (called a contraindication).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-other-medications\">Other Medications<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Some drugs and substances react with other drugs and change how they work. Clinicians call this an interaction, and it means some medications make Wegovy unsuitable.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There aren\u2019t any direct drug-drug interactions. However, Wegovy slows down the stomach. So it may affect how some medications are absorbed \u2013 especially when you increase your dose.&nbsp;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is particularly relevant for <strong>antibiotics<\/strong> and <strong>drugs with a low therapeutic index<\/strong>, like warfarin or insulin. In low therapeutic index drugs, there is a narrow margin between an effective dose and a dose that\u2019s either harmful or ineffective. So even very small changes in absorption or blood levels can cause serious issues.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Side effects like diarrhoea or vomiting can also affect how well your body absorbs medication. If you\u2019re vomiting, your body may not absorb the drug at all. Dehydration can also concentrate drugs in your system, increasing the risk of side effects. So, if you\u2019re on medication and have persistent diarrhoea or vomiting, please consult us for support.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you&#8217;re taking any medication, please let us know on your assessment form.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-who-cannot-take-wegovy\">Who Cannot Take Wegovy?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Not everyone is suitable for Wegovy. You cannot use Wegovy if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Are a child (under 18s)<\/li>\n\n\n\n<li>Are pregnant, trying to get pregnant or breastfeeding<\/li>\n\n\n\n<li>Have type 1 diabetes<\/li>\n\n\n\n<li>Have a history of pancreatitis<\/li>\n\n\n\n<li>Have a history (personal or family) of Medullary Thyroid Cancer or MEN2 syndrome<\/li>\n\n\n\n<li>Have an allergy to semaglutide or the ingredients in Wegovy<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-wegovy-and-cancer-is-there-a-link\">Wegovy and Cancer: Is There a Link?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">You might have heard there is a connection between Wegovy and cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One animal study has suggested a possible link between GLP-1 medication and thyroid cancer. The study found that GLP-1 receptor activation caused thyroid tumours in rodents.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Researchers have not found this effect in humans. However, as a precaution, we don\u2019t recommend Wegovy for those who\u2019ve had some thyroid cancers. Or those who have a family history of thyroid cancer. This includes medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 (MEN2).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-are-the-long-term-side-effects-of-wegovy\">What are the Long-Term Side Effects of Wegovy?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Clinical evidence shows no concerns regarding the safety of using Wegovy long-term.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We recommend staying on the treatment for as long as it\u2019s beneficial. Staying on the medication during the maintenance phase of your journey will help you build sustainable habits. This will make it easier for you to manage your weight if you choose to stop taking the medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">We won\u2019t stop prescribing you the medication when you reach your goal weight. Our clinicians will continue to prescribe it to you \u2013 as long as you\u2019re still benefiting from it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-is-wegovy-safe\">Is Wegovy Safe?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/wegovy\/is-wegovy-safe\/\">Yes. Wegovy is safe<\/a>. The UK\u2019s medicines regulator approved it as a weight loss medication in 2021. Since it launched in the UK in 2023, thousands of people have used it to safely manage their weight.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The UK regulator has also approved Wegovy as a preventative treatment for patients with heart disease. A recent study found it cut the risk in repeat heart events, like stroke and heart attack, in overweight and obese patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Like all medicines, Wegovy has risks as well as benefits. You do risk serious side effects, although these are less common.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While Wegovy is safe for most people, <strong>it is not safe for everyone<\/strong>. Patients with certain health conditions will not be able to use Wegovy. That\u2019s why your provider <strong>must<\/strong> carry out a comprehensive assessment before prescribing it. And it\u2019s crucial you\u2019re honest about your medical history.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-getting-support-for-wegovy-side-effects\">Getting Support for Wegovy Side Effects<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Before you start Wegovy, your prescriber will look at your medical history and health profile. They will advise if it\u2019s safe for you to use. They\u2019ll also let you know what side effects you can expect on the medication.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you experience any side effects on Wegovy, let your clinician know. They might alter your dosage or give you advice to help you feel more comfortable.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">And if you have any concerns at all about your side effects, contact your prescriber. They\u2019ll be able to provide you with support or alleviate any concerns. At Simple, we\u2019re here for you throughout your journey. Call us on <a href=\"tel:+441417745023\">0141 774 5023<\/a> if you need support.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-references\">References<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Package leaflet: Information for the patient Wegovy FlexTouch. (n.d.). Available at: <a href=\"https:\/\/www.medicines.org.uk\/emc\/files\/pil.13800.pdf\" target=\"_blank\" rel=\"noreferrer noopener nofollow\" rel=\"dofollow\" >https:\/\/www.medicines.org.uk\/emc\/files\/pil.13800.pdf<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">www.wegovy.com. (n.d.). <em>Wegovy\u00ae Side Effects | Wegovy\u00ae (semaglutide) Injection 2.4 mg. <\/em>[online] Available at: <a href=\"https:\/\/www.wegovy.com\/taking-wegovy\/side-effects.html\" target=\"_blank\" rel=\"dofollow noreferrer noopener\">https:\/\/www.wegovy.com\/taking-wegovy\/side-effects.html<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Hansen, M.S., W\u00f6lfel, E.M., Jeromdesella, S., M\u00f8ller, J.-J.K., Ejersted, C., J\u00f8rgensen, N.R., Eastell, R., Hansen, S.G. and Frost, M. (2024). Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial. <em>eClinicalMedicine<\/em>, 72, p.102624. doi: <a href=\"https:\/\/doi.org\/10.1016\/j.eclinm.2024.102624\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1016\/j.eclinm.2024.102624<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Lau, D.C.W., Batterham, R.L. and le Roux, C.W. (2022). Pharmacological profile of once-weekly injectable semaglutide for chronic weight management. <em>Expert Review of Clinical Pharmacology<\/em>, 15(3), pp.251\u2013268. doi: <a href=\"https:\/\/doi.org\/10.1080\/17512433.2022.2070473\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">https:\/\/doi.org\/10.1080\/17512433.2022.2070473<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-authorship\">Authorship<\/h3>\n\n\n\t\t<div data-elementor-type=\"container\" data-elementor-id=\"14945\" class=\"elementor elementor-14945\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec8f702 e-flex e-con-boxed e-con e-parent\" data-id=\"ec8f702\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-73a1dc0 elementor-position-left elementor-vertical-align-middle elementor-widget__width-auto elementor-widget elementor-widget-image-box\" data-id=\"73a1dc0\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/isabel-finch\/\" tabindex=\"-1\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/01\/isabel-finch-headshot.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-13552\" alt=\"Isabel Finch - Content Manager (headshot)\" srcset=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/01\/isabel-finch-headshot.jpg 150w, https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/01\/isabel-finch-headshot-70x70.jpg 70w, https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/01\/elementor\/thumbs\/isabel-finch-headshot-r0ojxgksdzdbfxiemx48y9z9ca8sqm2kbllzhr286g.jpg 100w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h4 class=\"elementor-image-box-title\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/isabel-finch\/\"><h4>Authored by Isabel Finch<\/h4><\/a><\/h4><p class=\"elementor-image-box-description\"><b>Content Manager<\/b>\n<br>Isabel Finch is the Content Manager at Simple Online Pharmacy, joining the team in August 2024. She started her career as a pharmacy journalist in 2018 and has since worked as a content writer and editor for a number of publications and brands. Her goal is to simplify healthcare and make sure advice is as clear and accessible as possible.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\n\n\t\t<div data-elementor-type=\"container\" data-elementor-id=\"15075\" class=\"elementor elementor-15075\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec8f702 e-flex e-con-boxed e-con e-parent\" data-id=\"ec8f702\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-73a1dc0 elementor-position-left elementor-vertical-align-middle elementor-widget__width-auto elementor-widget elementor-widget-image-box\" data-id=\"73a1dc0\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/richard-wood\/\" tabindex=\"-1\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/06\/richard-wood-150px.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-15596\" alt=\"Richard Wood, Pharmacist\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h4 class=\"elementor-image-box-title\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/richard-wood\/\"><h4>Medically Reviewed by Richard Wood<\/h4><\/a><\/h4><p class=\"elementor-image-box-description\"><b>Pharmacist \/ Clinical Specialist<\/b><br><b>GPhC reg:<\/b> \n<a href=\"https:\/\/www.pharmacyregulation.org\/registers\/pharmacist\/2078802\" target=\"_blank\" rel=\"noopener\">2078802<\/a>\n<br>Richard is a pharmacist and content reviewer at Simple Online Pharmacy. He officially joined the team in 2024 after several years of working with the company as a contractor. Prior to that, he spent over 11 years as a community pharmacist, building a strong foundation in patient care.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n\n\n\t\t<div data-elementor-type=\"container\" data-elementor-id=\"15025\" class=\"elementor elementor-15025\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec8f702 e-flex e-con-boxed e-con e-parent\" data-id=\"ec8f702\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-73a1dc0 elementor-position-left elementor-vertical-align-middle elementor-widget__width-auto elementor-widget elementor-widget-image-box\" data-id=\"73a1dc0\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/laura-perez\/\" tabindex=\"-1\"><img decoding=\"async\" width=\"150\" height=\"150\" src=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/06\/laura-perez-150.jpg\" class=\"attachment-thumbnail size-thumbnail wp-image-14971\" alt=\"Laura Perez\" srcset=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/06\/laura-perez-150.jpg 150w, https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/06\/laura-perez-150-70x70.jpg 70w, https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/wp-content\/uploads\/2025\/06\/laura-perez-150-80x80.jpg 80w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h4 class=\"elementor-image-box-title\"><a href=\"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/laura-perez\/\"><h4>Medically Reviewed by Laura Perez<\/h4><\/a><\/h4><p class=\"elementor-image-box-description\"><b>Content Writer \/ Clinical Nutrition Lead<\/b>\n<br>\n<b>British Dietetic Association membership no: 24597<\/b>\n<br>\nWith many years of experience as a clinical dietitian, Laura Perez specialises in delivering personalised nutrition services to help patients achieve their health goals through informed dietary choices. As the Lead Dietitian at Simple Online Pharmacy, Laura oversees the clinical aspects of nutrition and eating disorders, providing expert guidance and recommendations.<\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n","protected":false},"excerpt":{"rendered":"<p>Like all medications, Wegovy has side effects. Most are mild and manageable, but some are more serious. Learn what to expect, how to reduce discomfort, and when to seek medical support.<\/p>\n","protected":false},"author":22,"featured_media":16696,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87,86],"tags":[216],"treatments":[],"class_list":["post-16659","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-wegovy","category-weight-loss","tag-weekly-wego-novo"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Wegovy Side Effects | A Complete Guide<\/title>\n<meta name=\"description\" content=\"Discover Wegovy side effects, from common ones like nausea and tiredness to rarer risks. 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