{"id":3513,"date":"2023-02-14T00:00:00","date_gmt":"2023-02-14T00:00:00","guid":{"rendered":"https:\/\/go.simpleonlinepharmacy.co.uk\/uncategorized\/how-long-does-orlistat-stay-in-your-system\/"},"modified":"2025-07-11T13:03:49","modified_gmt":"2025-07-11T13:03:49","slug":"how-long-does-orlistat-stay-in-your-system","status":"publish","type":"post","link":"https:\/\/www.simpleonlinepharmacy.co.uk\/health-advice\/weight-loss\/orlistat\/how-long-does-orlistat-stay-in-your-system\/","title":{"rendered":"How Long Does Orlistat Stay in Your System?"},"content":{"rendered":"\n

Last Updated: 25\/06\/2025<\/em><\/p>\n\n\n\n

Orlistat<\/a>\u00a0(also known by its branded names\u00a0Xenical<\/a>\u00a0and Alli)\u00a0is a weight loss drug<\/a> which can be used by those with BMI over 25 (classed as overweight or obese). BMI (Body Mass Index)<\/a> is a method of categorising people\u2019s body weight. To calculate BMI, you can divide your weight (in KG) by your height (in metres) squared. Values between 25-29.9 are classified as overweight, while values above 30 are classified as obese.<\/p>\n\n\n\t\t

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Take an assessment and order Orlistat today from \u00a311.95<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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How Does Orlistat Work?<\/h2>\n\n\n\n

Orlistat is a lipase inhibitor. When you eat food, it is broken down by enzymes in your stomach and intestines. One of these enzymes is called lipase, which breaks down fats in foods you consume. Orlistat works by blocking lipase from digesting fats. Orlistat blocks about one third of the fat you consume in meals; this has a knock on effect of reducing the number of calories absorbed by the body. These undigested fats are removed through the faeces. <\/p>\n\n\n\n

Orlistat comes in capsule form, to be taken 3 times a day orally. It should be taken with each meal that contains fat. If the meal does not contain any fat or contains more than 15 grams of fat, you should not take Orlistat. Orlistat alone will not help you burn fat and lose weight – it needs to be coupled with a reduced calorie diet and regular exercise.<\/p>\n\n\n\n

The recommended timeframe for treatment is 3 months, but can be extended if there isn\u2019t a reduction in body weight by 5% during this period. A 6-month dose-ranging study group<\/a> found that Orlistat reduced the weight of patients taking 120mg three times a day for 6 months by 39% (with a reduced calorie diet). With Orlistat, you can expect to lose about 30% of your weight, with diet and exercise. <\/p>\n\n\n\n

Orlistat\u2019s Timeline<\/h2>\n\n\n\n

Once taken, Orlistat has immediate action on the body. You might notice weight loss as soon as 2 weeks, but the main weight loss is usually during the first 6 months of using Orlistat. <\/p>\n\n\n\n

Depending on your digestive tract and your bowel transit time (the amount of time it takes for food to travel through the GI tract), Orlistat only stays in your system for 12-72 hours. Many sources<\/a> have highlighted that once Orlistat has been discontinued, the faecal fat levels returned to pre-Orlistat levels within 48-72 hours.\u00a0<\/p>\n\n\n\n

Once you stop taking Orlistat, you may notice that you gain weight again. This \u201cbounce back\u201d is natural, and can be minimised by sticking to your diet and exercise plan, although some weight may come back if you continue to eat fatty foods.<\/p>\n\n\n\n

How to Get Orlistat?<\/h2>\n\n\n\n

Orlistat is not an over the counter medication, and needs to be prescribed by a healthcare professional. At Simple Online Pharmacy, we can prescribe Orlistat<\/a> once you complete an online assessment with us. After one of our doctors or pharmacists reviews your answers, and if they have no concerns, they will prescribe you Orlistat and we will post it straight to your doorstep.\u00a0<\/p>\n\n\n\n

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\"Ian<\/a><\/figure>

Authored by Ian Coakley<\/h4><\/a><\/h4>

Medical Content Writer<\/b>\n

Ian is a content writer at Simple Online Pharmacy. With a background in science communication, editing, and freelance writing, Ian aims to empower readers with accessible health information.<\/p><\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\n","protected":false},"excerpt":{"rendered":"

Orlistat can be a very effective tool for weight loss. Today, we look at how long it takes to see effects, and how long it lasts.<\/p>\n","protected":false},"author":7,"featured_media":3514,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[113],"tags":[219],"treatments":[],"class_list":["post-3513","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-orlistat","tag-weight-loss-pills"],"yoast_head":"\nHow Long Does Orlistat Stay in Your System? | Simple Online Pharmacy<\/title>\n<meta name=\"description\" content=\"Understand how long Orlistat remains active in your system, including its metabolism and excretion timeline, to manage your treatment plan effectively.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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