Paludrine/Avloclor Travel Tablets
  • Paludrine/Avloclor Travel Tablets

Paludrine/Avloclor Travel Tablets

From £16.25

Medication features

  • Effective Anti-Malarial Treatment
  • Start taking a week before entering the malarial zone
  • Contains Proguanil Hydrochloride & Chloroquine Phosphate


Buy Paludrine/Avloclor Travel Tablets Online

Paludrine/Avloclor Anti-malarial Travel Pack tablets are used in certain parts of the world to help prevent malaria. This is a serious disease spread by infected mosquitoes. Your Anti-malarial Travel Pack will give some degree of protection (prophylaxis) against malaria in certain countries.

It can be used when it is necessary to take more than one type of medicine at the same time to help prevent malaria. Medicines to help prevent malaria (malaria prophylaxis) are recommended for:

  • People travelling to countries where malaria occurs.
  • People living in malaria areas who are not immune to malaria.

These people have little or no immunity to malaria, so they are at risk of severe attacks.

You must get medical advice on which anti-malarial medicines to take. You must ask your doctor or pharmacist if this Anti-malarial Travel Pack is suitable for the part of the world that you are visiting.

Avoiding mosquito bites
When you are taking this medicine to prevent malaria, you should also reduce the chances of being bitten by mosquitoes.

  • Wear light-coloured, long-sleeved clothing and long trousers when you are outside after sunset.
  • Use insect repellent creams or sprays on parts of your body not covered by clothing.
  • Sleep in a properly screened room or under a mosquito net.
  • Spray to kill any mosquitoes that may have entered rooms in spite of screening.

If you have a high temperature
No medicine can be guaranteed to protect against malaria in every case. If you have a high temperature (fever) during your visit to a malaria area, or up to a year after returning home, you should suspect malaria. Contact a doctor straight away and let him or her know that you have visited a malaria area.

Side Effects

Side Effects of Paludrine/Avloclor Travel Tablets

Like all medicines, your Anti-malarial Travel Pack can cause side effects, although not everybody gets them.

Allergic reactions

If you have an allergic reaction, stop using your Anti-malarial Travel Pack and get medical help or contact your doctor straight away. The signs may include:

  • Difficulty in breathing.
  • Swelling of the face, lips, tongue or throat which may cause difficulty in swallowing.
  • An itchy rash (similar to nettle rash or hives).

Other possible side effects


  • Changes in the way your heart works (known as ‘electrocardiographic changes’).
  • Low blood pressure. This may make you feel faint or dizzy.
  • Cardiac muscle disease (cardiomyopathy) which may be fatal in the case of high-dose long-term use (rare). 
  • Abnormal heart rhythm, life-threatening irregular heart rhythm (seen on ECG).


  • Inflammation of the lungs causing a condition known as diffuse parenchymal lung disease. If you develop serious breathlessness or worsening of breathlessness seek prompt medical advice.


  • Mouth ulcers.
  • Inflamed mouth.

Nervous system

  • Headache
  • Feeling dizzy or light-headed.
  • Convulsions or fits.
  • Involuntary muscle movements or spasms


  • Insomnia
  • Mood changes or other effects on behaviour. These include feeling: depressed, confused, anxious, or rarely, seeing, feeling or hearing things that are not there (hallucinations).


  • Skin rash, including a scaly rash (psoriasis) or itch, which sometimes causes swelling of the affected area.
  • Peeling or scaly skin.
  • A severe rash with blisters or peeling of the skin and possibly blisters in the mouth and nose.
  • Discolouration of the skin or mucous membranes (such as the inside of your mouth).
  • Being sensitive to sunlight which may require medical treatment.
  • The appearance of small fluid filled bumps on the skin


  • Changes in hair colour.
  • Hair loss (sometimes reversible).


  • Blurred eyesight.
  • Some or complete loss of eyesight.
  • Problems with your colour vision.
  • Difficulty in focussing your eyes.
  • Double vision.
  • Changes to the retina of your eye(s) leading to ‘patchy’ eyesight (retinopathy).

If you are using your Anti-malarial Travel Pack for a long time, your doctor may suggest that you have eye tests.


  • Hearing loss.
  • Ringing in the ears (tinnitus).


  • A reduced number of blood cells. This can lead to easy or unexplained bruising, serious
    infections, sudden bleeding or feeling very tired, weak or breathless.

If you are using your Anti-malarial Travel Pack for a long time, your doctor may suggest that you have blood tests.


  • Liver problems which may cause yellowing of your skin or the whites of your eyes.

If you are using your Anti-malarial Travel Pack for a long time, your doctor may suggest that you have blood tests to check how well your liver is working.

Stomach and gut

  • Stomach upsets, feeling sick (nausea), being sick (vomiting), diarrhoea, constipation, stomach cramps.


  • High temperature (fever).
  • Inflammation of blood vessels, which can cause tiredness, weakness, loss of appetite, rash, ulcers, bloodshot eyes, pain in the joints, breathlessness and weight loss.
  • The weakening of your muscles (neuromyopathy and myopathy).
  • A rash caused by the medicine associated with an increase in the number of white blood cells (that may show up in blood tests) and symptoms involving the whole body. You may notice some or all of the following symptoms: a skin rash and fever, swelling of the face, tender generalized swollen or enlarged lymph nodes, or other symptoms suggesting involvement of other body organs including the liver, kidney or lung (such as yellowing of the skin or eyes, urinary problems, breathlessness).
  • Lowering of the blood glucose level

Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at, or by contacting us.


Directions of use for Paludrine/Avloclor Travel Tablets

If this medicine is from your doctor or pharmacist, take it exactly as they have told you. Otherwise, follow the instructions below. If you do not understand the instructions, or you are not sure, ask your doctor or pharmacist.

When to start taking your medicine

  • Start taking this medicine one week before you enter the malaria area.
  • You must continue to take it during your stay.
  • You must keep taking this medicine for 4 weeks after leaving the malaria area.

Adults and children over 14 years

  • Take two Avloclor tablets once a week on the same day each week.
  • And take two Paludrine tablets daily, at the same time each day.


Do not use this Anti-malarial Travel Pack in children under 1 year of age. For children over 1 year of age, the dose depends on the child’s age.

  • Ages 1 to 4 years: Take half an Avloclor tablet once a week (on the same day each week) and take half a Paludrine tablet daily (at the same time each day).
  • Ages 5 to 8 years: Take one Avloclor tablet once a week (on the same day each week) and take one Paludrine tablet daily (at the same time each day).
  • Ages 9 to 14 years: Take one and a half Avloclor tablets once a week (on the same day each week) and take one and a half Paludrine tablets daily (at the same time each day).

How to take your tablets

  • Take the tablet(s) after food.
  • Swallow the tablet(s), or part tablets, whole with a drink of water.
  • For a young child, the tablet(s) may be given crushed in milk, honey or jam.


Warnings for Paludrine/Avloclor Travel Tablets

Do not use this Anti-malarial Travel Pack if:

  • You are allergic to proguanil hydrochloride, chloroquine phosphate or any of the other ingredients in the tablets.
  • You are taking a medicine called amiodarone (used to control the heart rate). Avloclor may increase the risk of uneven heart beats (cardiac arrhythmias) when it is taken at the same time as amiodarone. Check with your doctor or pharmacist if you are not sure.

Warnings and precautions

Check with your doctor or pharmacist before taking your medicine if:

  • You have ever had epilepsy, convulsions or fits.
  • You have ever had problems with your liver or kidneys.
  • You have ever been told that you have a rare disease of the blood pigment called ‘porphyria’ or anyone in your family has it.
  • You have a scaly condition of the skin called psoriasis.
  • You have a muscle problem called ‘myasthenia gravis’. Avloclor can increase the symptoms of this condition. It can also reduce the effect of medicines used to treat this condition (neostigmine and pyridostigmine).
  • You have a blood problem called ‘glucose-6-phosphate dehydrogenase deficiency’.
    Avloclor may damage blood cells in people with this blood condition.

If you are not sure if any of the above apply to you, talk to your doctor or pharmacist before using your Anti-malarial Travel Pack.

Chloroquine can cause lowering of the blood glucose level. Please ask your doctor to inform you of signs and symptoms of low blood glucose levels. A check of the blood glucose level may be necessary.

Chloroquine may cause heart rhythm disorders in some patients: caution should be taken when using chloroquine, if you were born with or have family history of prolonged QT interval, if you have acquired QT prolongation (seen on ECG, electrical recording of the heart), if you have heart disorders or have a history of heart attack (myocardial infarction), if you have salt imbalance in the blood (especially low level of potassium or magnesium, see section “Other medicines and your Anti-malarial Travel Pack”).

If you experience palpitations or irregular heart beat during the period of treatment, you should inform your doctor immediately. The risk of heart problems may increase with increase of the dose. Therefore, the recommended dosage should be followed.

If you go into hospital, tell the medical staff that you are taking both Paludrine and Avloclor.

If you live in a country where malaria occurs, you may already be slightly immune to the
disease. You must ask a doctor or pharmacist for advice before you take anti-malarial


Ingredients in Paludrine/Avloclor Travel Tablets

Paludrine/Avloclor Anti-malarial Travel Pack contains two types of tablets, Paludrine tablets and Avloclor tablets.

Paludrine tablets:

  • The active substance in Paludrine tablets is proguanil hydrochloride. Each tablet contains 100 mg of proguanil hydrochloride.
  • The other ingredients are calcium carbonate, gelatin, magnesium stearate (E572) and maize starch.

Avloclor tablets:

  • The active substance in Avloclor tablets is chloroquine phosphate. Each tablet contains 250 mg of chloroquine phosphate (equivalent to 155 mg of chloroquine base).
  • The other ingredients are magnesium stearate (E572) and maize starch.

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