Intermittent fasting is an effective way to help lose weight. In trials it works around about as well as cutting your calories. Alternate day fasting came out as the most effective strategy, by about 1.3kg.1

Does intermittent fasting work for weight loss?

Yes. Every fasting pattern that has been measured has led to weight loss compared with eating freely. Most of the people in those trials already had a health condition. 1

Across trials, people usually lost between 0.8% and 13% of their starting weight.2 As with any weight loss diet, fasting works by helping keep the calories you take in below the calories you burn.3 How much you lose will still depend on how much less you eat overall.

16:8, 5:2 and alternate day fasting explained

What are the main types of fasting patterns? There are 3 main fasting patterns people use when trying to lose weight. They are:

  • 16:8, or time restricted eating. You eat inside an eight hour window, say midday to 8pm, and take nothing with calories in it for the other 16 hours.4 You can also do this from 9am to 5pm, or whatever pattern best fits your lifestyle.
  • 5:2, or whole day fasting. This is when you fast all day for 2 days a week. On your fasting days you should still eat about 400 calories if you are a woman, or 600 calories for men. Your fasting days should not be next to each other. So have at least one eating day between them. You then eat as usual on the other five.5
  • Alternate day fasting. You alternate a fasting day with a normal eating day. In most trials the fasting day still included a small amount of food.8

Does the fasting window itself do anything?

Not really much on its own. When a 16:8 window was the only change people made, they lost just under 1kg over 12 weeks. That wasn't really any better than eating across the day.4

The larger results come from fasting plus eating less. Fasting often makes this easier to do. People who kept to an 8am to 4pm window and counted calories lost around 8kg in a year. Calorie counting on its own resulted in an average loss of 6.3kg.6

So eating less overall is what shifts the weight. A fasting window is one way of helping make that happen.

Is one fasting pattern better than the others?

Yes, but only slightly. Alternate day fasting beat the 16:8 pattern by about 1.7kg and whole day fasting by about 1kg.1

If you are considering fasting, pick the pattern that best fits your day. For example, a midday to 8pm window suits someone who skips breakfast anyway. But if you love your breakfast, and enjoy an early dinner, 8am-4pm might be best for you. Meanwhile, two low calorie days a week suit someone who would rather not change every day.

Fasting or counting calories every day?

Each method works about as well as the others. Alternate day fasting is the one exception, and it resulted in higher weight loss than daily calorie cutting, by about 1.3kg.

Fasting does not necessarily give a significantly better weight loss result than ordinary dietary advice.7 If you are able to adopt both healthier eating habits AND reduce your calories, this can be your best long term route.

Some people might struggle to do both, and so smaller, more gradual changes in your habits can be easier to make. This can ultimately be more beneficial, as they are easier to stick to.

Everyone is different, and some people will also find "treat" days an effective way to motivate themselves to complete their fasting days.

Does it still work after six months?

Yes, fasting continues to work long term.

However, most of the weight comes off in the first one to six months. People can sometimes hit a plateau after that.8

Will I lose muscle as well as fat?

Possibly a little. Fasting has been linked to a drop in fat-free mass. This is the weight of everything in your body that is not fat.8

Increasing your protein intake can help prevent this.

If that concerns you, our advice on how to prevent muscle loss while losing weight covers what helps.

What fasting does to cholesterol and blood sugar

Alternate day fasting lowered total cholesterol and triglycerides, another fat in your blood, compared with a 16:8 window. A 16:8 window slightly raised total cholesterol and LDL, the unhealthy type, compared with whole day fasting. Fasting, daily calorie reduction and eating freely made no difference to HbA1c, which is the longer term measure of blood sugar, or to HDL cholesterol.1

Side effects, and when to stop

Fasting does not raise the overall risk of side effects.5 Around 1 in 7 people felt tired when fasting, and about 1 in 7 had a headache, while around 1 in 10 were constipated or felt dizzy.5

No trial reported a major or severe side effect.5 If you feel dizzy, you should have a small snack.5

Don't push yourself if you find you are incredibly fatigued or dizzy. You may want to take things a little slower until your body adjusts.

When to stop fasting and get help

Stop fasting if you get symptoms of low blood sugar. This mainly affects people with diabetes who take insulin or some other diabetes medicines, and is rare without diabetes.9

If you take diabetes medicines and your blood sugar drops below 4mmol/L, you should break your fast. Treat the low blood sugar, or hypo, with sugary food or drink, then follow it with something starchy.10

Use NHS 111 online if you need urgent medical help that is not an emergency.10 See a GP if you do not have diabetes and get symptoms such as shaking, sweating, a fast heartbeat and feeling confused.9

Who should check with a clinician first

Check with your GP, pharmacist or diabetes team before you start if you take insulin or a medicine that can cause low blood sugar. Fasting can be dangerous if you have diabetes.10

If you are at risk of low blood sugar, do not skip or delay meals.9 That is the opposite of what a fasting window asks of you.

Any dietary approach has to be tailored around conditions such as eating disorders, disordered eating and type 1 diabetes. If one of these applies to you, speak to your GP or diabetes team before you try a fasting window.3

Restrictive diets that are nutritionally unbalanced should be avoided, because they don't work long term and can be harmful.3

For children and young people, healthy eating rather than overly restrictive diets is advised. So fasting windows are for adults only.3

How to fit a fasting window around NHS weight loss advice

Treat a fasting window as one way of eating less overall. Skipping meals can backfire, because you may end up snacking more when you get hungry. Losing weight suddenly through diets is not recommended either.12

A realistic rate of loss

You can aim to lose 1 to 2lbs, or 0.5 to 1kg, a week. Aim to be active for around 150 minutes a week, which you can break into shorter sessions. Change one thing at a time rather than everything at once.12

In many cases the weight comes back, so decide now what you will do when the fasting stops.3 Our tips for losing weight cover the parts that have nothing to do with the clock.

Habits that make an eating window easier

Swap sugary drinks for water. Aim for your 5 A Day, counting 80g of fruit or vegetables as one portion. Cut down on food high in sugar and fat. Tell someone you trust about your plan, so you have support on a bad day.12

Where to get NHS help with your weight

You may be able to refer yourself to an NHS weight management service without seeing a GP. Ask the reception staff at your GP surgery what is available near you. NHS Better Health also runs a free weight loss plan app.12

Frequently asked questions

How much weight will I lose in the first week of 16:8?

There is no reliable one week figure. Trials measured change over weeks and months rather than days. A 16:8 window on its own gave just under 1kg over 12 weeks, and a window with calorie counting gave 8kg over a year. You can aim for around 0.5 to 1kg a week and judge it after a month or two.

Is 16:8 better than 5:2?

No. Both reduced weight compared with eating freely, and neither beat daily calorie cutting. Alternate day fasting edged ahead of both, by too little to matter in practice.

How does intermittent fasting actually work?

It works by keeping the calories you take in below the calories you burn. A shorter eating window tends to mean fewer meals and less food. The idea that changing your metabolism brings a further long term benefit is still a hypothesis.8

Does intermittent fasting improve blood sugar?

No. Fasting, daily calorie cutting and eating freely made no difference to HbA1c between them. If you have diabetes, speak to your diabetes team before you change when you eat.

Can I fast if I take insulin or diabetes tablets?

Not without speaking to your diabetes team first. Some diabetes medicines can cause low blood sugar, and fasting can be dangerous if you have diabetes. If your blood sugar drops below 4mmol/L, break the fast and treat the hypo.

Can I fast if I am taking weight loss medication?

Ask your prescriber before you change your eating pattern, because that is a decision about your treatment rather than your diet alone. Our advice on fasting safely on GLP-1 medications covers the practical side.

Is intermittent fasting safe in pregnancy or when breastfeeding?

No UK guidance on weight management covers fasting in pregnancy, so the evidence cannot say either way. Speak to your midwife or GP before you change how you eat while pregnant or breastfeeding.

What happens if I stop fasting?

The weight often comes back, as it can after any diet. Most of the loss happens in the first one to six months anyway, and it tends to plateau after that. What you do next matters more than which pattern you picked.

Does NICE recommend intermittent fasting?

No. The UK guideline on managing overweight and obesity treats intermittent fasting in adults as a question for more research rather than a dietary recommendation.3

Key takeaways

  • Fasting helps because it makes you eat less. Pick the pattern you can keep to.
  • Expect 0.5 to 1kg a week, and judge your progress over months rather than days.
  • Check with your GP, pharmacist or diabetes team before you start if you take insulin or a medicine that can cause low blood sugar.

Sources

References

This page lists 12 sources. Numbered markers in the text link to 11 of them, and a pharmacist approved each of those citations. Each cited source links back to where it is cited.

  1. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials, BMJ, 2025 [Accessed 21 October 2026]. Relevant sections: Abstract, Conclusions; Abstract, Results; Abstract, Results, first sentence. https://pubmed.ncbi.nlm.nih.gov/40533200/

  2. Intermittent fasting and weight loss: systematic review, Canadian Family Physician, 2020 [Accessed 21 October 2026]. Relevant section: Abstract, Synthesis. https://pmc.ncbi.nlm.nih.gov/articles/PMC7021351/

  3. Overweight and obesity management (NG246): physical activity and diet, NICE, 2026 [Accessed 21 October 2026]. Relevant sections: Recommendation 1.16.3; Recommendation 1.16.1, bullet; Recommendation 1.16.7; Recommendation 1.16.4; Recommendation 1.16.1, final bullet; Dietary approaches, Intermittent fasting in adults. https://www.nice.org.uk/guidance/ng246/chapter/Physical-activity-and-diet

  4. Effects of time-restricted eating on weight loss and other metabolic parameters in women and men with overweight and obesity, JAMA Internal Medicine, 2020 [Accessed 21 October 2026]. Relevant sections: Abstract, Interventions; Abstract, Results; Abstract, Conclusions and Relevance. https://pubmed.ncbi.nlm.nih.gov/32986097/

  5. Adverse events profile associated with intermittent fasting in adults with overweight or obesity: a systematic review and meta-analysis of randomized controlled trials, Nutrition Journal, 2024 [Accessed 21 October 2026]. Relevant sections: Table 1, Sundfør 2018 row, intermittent fasting regimen cell; Abstract, Conclusions; Discussion, paragraph on common adverse events; Results, Serious adverse events; Discussion, dizziness paragraph. https://pmc.ncbi.nlm.nih.gov/articles/PMC11234547/

  6. Calorie restriction with or without time-restricted eating in weight loss, New England Journal of Medicine, 2022 [Accessed 21 October 2026]. Relevant section: Abstract, Results. https://pubmed.ncbi.nlm.nih.gov/35443107/

  7. Intermittent fasting for adults with overweight or obesity, Cochrane Database of Systematic Reviews, 2026 [Accessed 21 October 2026]. Relevant sections: Plain language summary, Key messages; Abstract, Authors' conclusions. https://pmc.ncbi.nlm.nih.gov/articles/PMC12906965/

  8. Intermittent fasting and obesity-related health outcomes: an umbrella review of meta-analyses of randomized clinical trials, JAMA Network Open, 2021 [Accessed 21 October 2026]. Relevant sections: Discussion, second paragraph; Abstract, Findings; Results, final paragraph before Sensitivity Analyses; Introduction, first paragraph; Results, Description and Summary of Associations. https://pmc.ncbi.nlm.nih.gov/articles/PMC8683964/

  9. Low blood sugar (hypoglycaemia), NHS, 2023 [Accessed 21 October 2026]. Relevant sections: Opening paragraph; Symptoms of low blood sugar, first paragraph; How to treat low blood sugar yourself, step 1; Non-urgent advice: See a GP if, list; Immediate action required heading; Immediate action required: Call 999 if, paragraph; How to reduce your risk of low blood sugar, Don't list. https://www.nhs.uk/conditions/low-blood-sugar-hypoglycaemia/

  10. Diabetes and Ramadan, Diabetes UK, undated [Accessed 21 October 2026]. Relevant sections: Testing blood sugars during the fast, Risk of low blood sugar; Talk to your healthcare team about your blood sugar levels; Talk to your healthcare team about fasting; Quote from Professor Wasim Hanif. https://www.diabetes.org.uk/ramadan

  11. Overweight and obesity management (NG246), NICE, 2026 [Accessed 21 October 2026]. Relevant sections: Overview, first paragraph; Overview, see also line. https://www.nice.org.uk/guidance/ng246

  12. 12 tips to help you lose weight, NHS, undated [Accessed 21 October 2026]. Relevant sections: Things you can do to lose weight, Don't list; Things you can do to lose weight, Do list; Things you can do to lose weight, intro line; Self-refer for help with your weight; Self-refer for help with your weight, list; Further information, Get more weight loss advice from NHS Better Health. https://www.nhs.uk/live-well/healthy-weight/managing-your-weight/12-tips-to-help-you-lose-weight/

Reference links open the cited source pages. If you spot something out of date, tell our content team.

Who wrote this

Written and reviewed by our team

Authored by

Karim Nassar, Co-Founder, Pharmacist & Author

Co-Founder, Pharmacist & Author

Karim is a registered pharmacist with the General Pharmaceutical Council (GPhC) and was a founding member of Simple Online Healthcare in 2015. With a Master of Pharmacy degree from Strathclyde University, Karim brings a strong foundation in pharmaceutical care and a passion for leveraging digital solutions to improve patient access to healthcare.

Read Karim’s profile

Medically reviewed by

Karim Nassar, Co-Founder, Pharmacist & Author

Karim Nassar

Co-Founder, Pharmacist & Author

Karim is a registered pharmacist with the General Pharmaceutical Council (GPhC) and was a founding member of Simple Online Healthcare in 2015. With a Master of Pharmacy degree from Strathclyde University, Karim brings a strong foundation in pharmaceutical care and a passion for leveraging digital solutions to improve patient access to healthcare.

Read Karim’s profile

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