Evorel Sequi
  • Evorel Sequi

Evorel Sequi Patches

Medication features

  • Helps to treat the symptoms of the menopause
  • Patch that is attached to the skin twice a week
  • Contains the main ingredients oestrogen & progesterone


Order Evorel Sequi Patches Online

You can order Evorel Sequi patches online from our UK registered online pharmacy and doctor service. After completing an assessment, our UK registered doctors will review your order. If approved, our pharmacy team will dispense and dispatch your medication to your chosen address using discreet packaging. Our delivery options include standard and next day deliveries.

What is Evorel Sequi?

Evorel Sequi is a Hormone Replacement Therapy (HRT). It is used to relieve symptoms associated with menopause. It can also be used in post-menopausal women at risk of osteoporosis.

HRT uses oestrogen to replace the lost oestrogen from menopause. Most HRT products also contain a progestogen.

Evorel Sequi packs contain Evorel 50 (oestrogen-only patches) and Evorel Conti (oestrogen + progestogen patches). A treatment cycle is 28 days. During the first 14 days, Evorel 50 patches are worn and during the next 14 days, Evorel Conti patches are worn.

Evorel Sequi is called a continuous sequential HRT preparation. Before deciding if Evorel Sequi is right for you, you can see our collection of reviews from real patients so you can make an informed descision.

How does it work?

Levels of the female sex hormone oestrogen drop during menopause. This drop causes symptoms of menopause like night sweats, hot flushes, reduced sex drive, mood swings, and vaginal dryness. 

Evorel patches contain the active ingredient estradiol which is a form of oestrogen. This is absorbed through the skin and into the bloodstream. This replaces the oestrogen lost during menopause and relieves symptoms.

Taking oestrogen increases the risk of womb cancer because oestrogen causes an overgrowth of the endometrium (lining of the womb). Using a progestogen alongside an oestrogen protects against this increased risk of womb cancer. For that reason, most HRT products such as Evorel Sequi contain both an oestrogen and progestogen (estradiol and norethisterone). Women who have had their womb removed are able to take oestrogen-only HRT.


The patches should be applied to a hairless area of the body below the waist, it must not be applied on or near the breasts. Patches should not be applied to the same area twice in a row. They should be worn under loose-fitting clothing. Most women will prefer to apply the patch on the thighs or bottom.

Instructions on how to apply the patch are on page 10 of the patient information leaflet.

Evorel Sequi patches must be changed twice per week but they have to be used in the right order.

  • For the first two weeks of the pack, Evorel 50 patches should be used (changed twice per week, four patches in total).
  • For the third and fourth week of the pack, Evorel Conti patches should be used (changed twice per week, four patches in total).

If a patch falls off, replace it with the same type of patch. It is always useful to have a spare pack to replace any patches that fall off.

Evorel Sequi Summary


Apply patches to the skin as directed by the doctor in a 28-day cycle

Type of medicine

Hormone replacement therapy


Replaces oestrogen lost during menopause to relieve symptoms

Active Ingredients

50mcg/day estradiol & 170mcg/day norethisterone


From £26.99

Side Effects

Can include nausea, headaches, skin irritation, sleep problems

Evorel Sequi Prices

8 patches


16 patches


24 patches



Other forms of HRT include:

  • Vaginal creams
  • Vaginal gels
  • Tablets
  • Vaginal pessaries
  • Gels

Our doctors are able to prescribe the following HRT tablets:

  • Elleste Solo
  • Estring
  • Elleste Duet
  • Elleste Duet Conti
  • Evorel Conti
  • Trisequens
  • Provera
  • Estradot
  • Premique
  • Kliovance
  • Vagifem
  • Premarin
  • Livial
  • Prempak C

Various HRT products have suffered from long term shortages in the past two years. The products can differ slightly, making it hard to find a direct alternative when one is out of stock.

There are no direct alternatives to both Evorel Conti and Evorel Sequi. To achieve a similar dose an oestrogen-only patch (e.g Evorel 50) or gel (e.g Oestrogel) should be used alongside progestogen tablets (e.g Provera tablets).


How long does it take for Evorel Sequi to work?

The benefits of HRT treatment on symptoms can be seen within a few weeks but it may take up to 3 months for the full benefits of HRT to take effect.

Do HRT patches make you gain weight?

Some HRT products may cause weight gain as a side effect. The manufacturers of Evorel Sequi note that weight gain is a common (1-10%) side effect of the patches. Weight gain or weight loss may also be attributed to menopausal symptoms and lifestyle. 

Can I delay a period on Evorel Sequi?

Evorel Sequi is a continuous sequential HRT. This type of HRT will give a ‘withdrawal bleed’ like a period every month around week 4 of the patches. If you would like advice about delaying a period please discuss this with the relevant healthcare professionals, like your GP or pharmacist.

When should I bleed on Evorel Sequi?

A withdrawal bleed will start during the 4th week of the cycle before you finish the pack.

Can I order Evorel Sequi online?

Yes, you can Evorel Sequi online via our UK registered online pharmacy and doctor service. After having an online consultation, our doctors can assess your suitability for treatment and issue a prescription if necessary. 

Side Effects

Evorel Sequi side effects

There is always a risk of side effects when taking any medicine, although not everyone will experience them.

Common (1-10%)  side effects of Evorel Sequi include:

  • Nausea
  • Headache
  • Problems sleeping
  • Diarrhoea
  • Breast tenderness
  • Irritated skin where the patch is applied
  • Weight gain

These side effects may improve over time when using Evorel patches. If these side effects do not improve speak to your doctor or pharmacist.

The patient information leaflet for Evorel Sequi contains further information on the side effects of HRT.

HRT can be very beneficial for women with menopause symptoms however, there are potential risks associated with treatment. The following diseases are reported more often in women taking HRT compared to women not taking HRT:

  • Breast cancer
  • Stroke
  • Endometrial (womb) cancer 
  • Heart disease
  • Ovarian cancer
  • Blood clots (venous thromboembolism)

Oestrogen-only HRT has an increased risk of womb cancer but HRT containing progestogens, like Evorel Sequi, protects against this risk. 

The risk of blood clots in HRT users is highest during the first year of treatment. The increased risk is up to 3x higher in users of HRT compared with non-users.

The risks of taking HRT may be different in women who have early menopause. If this is the case for you, you should discuss these risks with your doctor.

There is evidence to suggest HRT use increases the risk of breast cancer. The risk increases the longer HRT is taken for. This increased risk returns to normal within about 5 years of stopping treatment.

Patients should be routinely monitored by their doctor during HRT treatment. Treatment with HRT should only be started if the benefits outweigh the risks and doctors should take a full medical history before prescribing. Further information can be found on the NHS website for breast cancer, blood clotsstroke and endometrial cancer as well as information on the risks of HRT.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at medicines.org, or by contacting us.


Other conditions and Evorel Sequi

During the online assessment, ensure you mention any medical conditions you have. 

Evorel Sequi should not be used in a number of conditions. If you develop any of these conditions during treatment you should stop taking HRT. Examples of these are:

  • Unexplained vaginal bleeding
  • A current blood clot or a history of blood clots
  • Current breast cancer or a history of breast cancer
  • A blood clotting disorder
  • If you currently have cancer that is sensitive to oestrogens, such as endometrial cancer, or have had it in the past
  • Endometrial hyperplasia (thickening of the womb lining)
  • Recent stroke or heart attack
  • Current liver disease or a history of liver disease

Interactions with other medicines

During the online assessment, make sure to list any medicines you currently take. Evorel Sequi should be used with caution with a number of medicines. These include:

  • Medicines for epilepsy such as carbamazepine and lamotrigine
  • The herbal medicine St John’s Wort
  • Bosentan, for high blood pressure in the lungs
  • Medicines for HIV infection
  • Medicines for tuberculosis

Gels and creams should not be applied to the same area of skin as the patches.

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Evorel Conti

Medication Simple Online Pharmacy
50mcg x8 £26.99
50mcg x16 £38.99
50mcg x24 Patches £55.99


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2.5mg x28 £20.99
2.5mg x84 £54.99


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0.5/1mg x84 £29.99

Elleste Duet

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1mg x84 £22.99
2mg x84 £22.99

Elleste Duet Conti

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2mg x84 £32.99
2mg x84 £32.99

Evorel Sequi Patches

Medication Simple Online Pharmacy
50mcg x24 £55.99
50mcg x8 £26.99
50mcg x16 £38.99


Medication Simple Online Pharmacy
0.3mg x84 £19.99
0.625mg x84 £19.99
1.25mg x84 £18.99

Elleste Solo

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1mg x84 £18.99
2mg x84 £18.99


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0.3mg/1.5mg x84 £22.99


Medication Simple Online Pharmacy
25mcg/24hr x8 - Patches £20.99
25mcg/24hr x16 - Patches £39.99
25mcg/24hr x24 - Patches £54.99
50mcg/24hr x8 - Patches £20.99
50mcg/24hr x16 - Patches £39.99
50mcg/24hr x24 - Patches £54.99
100mcg/24hr x8 - Patches £21.99
100mcg/24hr x16 - Patches £40.99
100mcg/24hr x24 - Patches £55.99
75mcg/24hr x8 - patches £21.99
75mcg/24hr x16 - Patches - patches £40.99
75mcg/24hr x24 - Patches £55.99
37.5mc/24hr x8 Pack £21.99
37.5mc/24hr x16 - Patches £40.99
37.5mc/24hr x24 - Patches £55.99


Medication Simple Online Pharmacy
2mg/1mg x84 £26.99


Medication Simple Online Pharmacy
1/10mg x84 £46.94
2/10mg x84 £46.94
Conti 0.5/2.5mg x84 £49.98
Conti 1/5mg x84 £49.98


Medication Simple Online Pharmacy
750mcg / actuation x80g £23.99
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