• Naproxen
  • Naproxen


Medication features

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and decrease fever. It's commonly used for conditions such as arthritis, muscle aches, and menstrual cramps.

  • Available as 500mg and 250mg 
  • Non-steroidal anti-inflammatory drug (NSAID)
  • Helps treat conditions such as  muscle pain, arthritis, period pain and gout


Buy Naproxen 500mg Tablets Online

You can buy Naproxen pain relief treatment online using our UK registered online doctor and pharmacy service. An online consultation in the form of an assessment is required to place an order. This can then be evaluated by our GPs who can make sure it is safe and suitable for you to take.

If approved by our doctors, a prescription is sent to our pharmacy team. It is dispensed and dispatched to your chosen delivery address. We use Royal Mail as a courier and have a range of delivery options.

What is Naproxen?

Naproxen is a painkiller medicine that specifically targets inflammatory pains. It belongs to a medicine class known as non-steroidal anti-inflammatory drugs (NSAIDs). Other medicines in this category include ibuprofen, aspirin and diclofenac. Typically people find that Naproxen provides more inflammatory pain relief than ibuprofen or aspirin.

Depending on the pain severity, 250mg or 500mg doses are available. The lowest effective dose should be used to minimise the chance of side effects. Pain and inflammation should be noticeably reduced in 30-60 minutes after taking a dose of Naproxen.

It is only available on prescription, although you can buy it over the counter for period pain and menstrual cramps from a pharmacy under the brand name Feminax Ultra.

What is Naproxen used for?

It is commonly prescribed for pain relief and to treat inflammation in conditions such as gout, rheumatoid arthritis, sprains and strains and osteoarthritis. Because NSAIDs do not have the potential to cause addiction such as opioid-based painkillers, it is the preferred treatment for those who suffer inflammatory pain. Naproxen (or other NSAIDs) along with paracetamol may make up the base of pain relief treatments before using potentially addictive medicines.

How does Naproxen work?

Non-steroidal anti-inflammatories such as Naproxen work by reversibly stopping enzymes in the body responsible for producing an inflammation causing substance known as prostaglandins. Prostaglandins usually signal the body to induce inflammation, by reducing their numbers in the body by slowing their production, inflammation is reduced.

Naproxen, Paracetamol & other painkillers

Yes, Naproxen can be taken alongside paracetamol or paracetamol/ codeine combinations such as co-codamol. However, it should not be taken with ibuprofen, aspirin, or diclofenac because they are from the same class of medicines (NSAIDs) and will cause increased side effects that may be dangerous.

It is important to note that many other medicines can contain NSAIDs or paracetamol in combination such as cold and flu medicines. This can lead to accidental double doses that can result in side effects. Always ensure you are aware of what is in each medicine you take before use.

As with all pain medicines, it is best to use the lowest effective dose required to avoid the potential side effects of treatments.

Naproxen dose

You should take it exactly as your doctor has told you to. The dose may vary from person to person depending on why your doctor has prescribed it. The usual Naproxen dosage is to take a dose twice a day with food.

Two strengths are available: Naproxen 250mg and Naproxen 500mg. Your doctor will decide the safest strength and dose for you. Usually, you should take the lowest effective dose for the shortest time. However, some people can be prescribed Naproxen long-term to relieve pain in chronic conditions.

If you have been prescribed Naproxen for a long time, it is important that you are aware of the ways to protect yourself from the potential side effects. Refer to warnings and precautions for more information.

Regular or gastro-resistant Naproxen

Naproxen is available as regular tablets or as gastro-resistant tablets. The gastro-resistant tablets have a coating that protects them from stomach acid and releases the drug later on in the gut. This can help to protect the stomach from being irritated by the drug.

Naproxen Summary


Take ONE tablet ONCE or TWICE daily with food as directed

Type of medicine

NSAID - Non-steroidal anti-inflammatory drug


Reduces prostaglandins in the body which lead to inflammation

Available Strengths

250mg & 500mg

Active Ingredient



From £10.94

Side Effects

Can include stomach upset, dizziness, headache, nausea.

Naproxen Prices

250mg x 28 Tablets


250mg x 56 Tablets


500mg x 28 Tablets


500mg x 56 Tablets


250mg x 28 GR Tablets


250mg x 56 GR Tablets


500mg x 28 GR Tablets


500mg x 56 GR Tablets


Naproxen Alternatives

For people unable to take this medicine, paracetamol is a suitable alternative as it can be used by most people. Other NSAIDs available over the counter include ibuprofen, aspirin, and topical diclofenac (Voltarol).

A number of other NSAIDs can be prescribed by your doctor if suitable. Examples include celecoxib, ketoprofen, and mefenamic acid.

Naproxen Side Effects

As with all medicines, there is a potential for side effects with Naproxen, although not everyone will get them. Common side effects of Naproxen include headache, dizziness, tiredness, and ringing in the ears. You can find more information on common and less common side effects in the patient information leaflet

When taking this medicine, there are some serious side effects to be aware of. If you notice any stomach problems like indigestion, nausea, stomach pain or vomiting, it may be a sign of a stomach ulcer. If you notice any of these symptoms, speak to your doctor immediately.

Other side effects to mention to your doctor immediately are if you notice black tarry stools or you vomit blood or particles that look like coffee grounds. If this occurs, stop taking naproxen immediately and seek medical advice.

It is important to read the patient information leaflet for further information regarding the potential side effects of treatment. 


Is Naproxen stronger than ibuprofen?

Both of these medicines are similar drugs and both are types of NSAIDs. Naproxen is generally more potent than low strength ibuprofen that you can get over the counter. However, doctors are able to prescribe higher strengths of ibuprofen which are similar to Naproxen. Both drugs can generally be used as first choice NSAIDs because they have fewer side effects than some other NSAIDs.

Does Naproxen make you drowsy?

Drowsiness is listed as a potential side effect although this may not happen to everyone. Unlike codeine-based painkillers, drowsiness is not an expected effect of the medicine. Avoid driving until you know how naproxen affects you.

Can I buy Naproxen over the counter?

Yes, A brand called Feminax Ultra is available over the counter to treat period pain. However, when used for other conditions such as rheumatoid arthritis, it is only available with a prescription. It is available as Naproxen 500 mg tablets on prescription.

Can you drink alcohol with Naproxen?

Yes, you can drink alcohol while taking Naproxen but it can increase the risk of stomach problems if you drink too much alcohol with it. Avoid alcohol if possible or drink responsibly to avoid stomach side effects.

Is Naproxen the same as ibuprofen?

It is a different drug to ibuprofen. However, they belong to the same group of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen can be bought over the counter whereas Naproxen is a prescription-only medicine (except when used for period pain). Both are anti-inflammatory painkillers.

Is Naproxen addictive?

It is not an addictive drug and does not carry the same risk of addiction as painkillers like codeine and morphine.

How long does Naproxen take to work?

You should notice a beneficial effect around 1 hour after taking a dose. However, if you are taking it long-term it can take a number of days for Naproxen to work and have the full anti-inflammatory effect.

Can I buy Naproxen online?

Naproxen, in the UK, is a prescription-only medicine. You can request to order it from certain registered online doctors and pharmacy services such as Simple Online Pharmacy.


Tyson Wilkman, Clinical Pharmacist


Tyson Wilkman

RoleClinical Pharmacist
Qual.Bachelor of Pharmacy (Honours)
AboutTyson started with Simple Online Pharmacy in 2021. He's responsible for helping author and review accurate site content. He works with our GPs to make sure all aspects of the medicines are covered.


What is the strongest painkiller?
Different painkillers may work well for one person but not another. Generally, paracetamol is the first painkiller people are advised to take. For more severe pain strong NSAIDs like Naproxen, or a weak opioid like codeine, may be prescribed. Generally, very strong painkillers like morphine and oxycodone are only prescribed by your doctor if your pain is very severe.

Is tramadol stronger than codeine?
Tramadol and codeine are very similar in terms of how strong they are. However, in the UK, tramadol is prescribed in higher strengths than codeine. It is also only available on prescription, so many people consider it to be stronger than codeine because codeine is available to buy from a pharmacy.

Which drugs are NSAIDs?
Ibuprofen, naproxen, diclofenac, and aspirin are all types of NSAIDs. They are often used for their anti-inflammatory effects.

Is paracetamol an NSAID?
No, paracetamol is not an NSAID. However, paracetamol can be an effective painkiller and is suitable for most people to take.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet: 


Naproxen Warnings and Precautions

If prescribed naproxen long term, it is important that you are aware of how to protect the stomach while using the medicine. Food should always be consumed before having a dose to protect the stomach from the effect of naproxen. Your doctor may decide to prescribe you a treatment to lower the stomach acid to help further.

Other conditions and Naproxen

It is not suitable for everyone to take. People who have had an allergic reaction to Naproxen or another NSAID should not take it. This includes people with asthma who have found their asthma worsened after taking an NSAID. 

People with a history of stomach ulcers or gastrointestinal diseases like Crohn’s or ulcerative colitis should not take Naproxen. People with severe liver, kidney, or heart failure are not able to take Naproxen. For a full list of conditions that can be affected by this medicine, see the patient information leaflet. If you are unsure, talk to your doctor or pharmacist for advice.

Interactions with other medicines

Naproxen can interact with a wide variety of medicines. Examples include blood-thinning medicines like warfarin, diuretics, and certain blood pressure medicines. It should also not be taken with other NSAIDs such as aspirin or ibuprofen. This includes low dose aspirin that people are often prescribed after a heart attack or stroke.

Interactions between Naproxen and other medicines can be dangerous and you should check with your doctor if you start any new medication whilst taking this medicine.

Naproxen in pregnancy and breastfeeding

Naproxen should not be used within the first 6 months of pregnancy without consultation with a doctor who can assess the risk versus benefit of the treatment. It should NOT be used at all within the last 3 months of pregnancy as it can result in serious complications.

Naproxen does pass into the breastmilk in small amounts. Due to this, it is not recommended to use naproxen during breastfeeding without direct instruction from a doctor.

Order within for guaranteed next day delivery options

ClosePrice Checker
Compare Prices
The variation selected is currently out of stock.
Item added to bag. Click here to view bag.
Please select a size from above to proceed.
There are NHS prescriptions in your basket. Please complete the order first or remove NHS prescriptions from the basket.


Medication Simple Online Pharmacy
250mg x28 x 250mg Tablets £10.94
250mg x56 x 250mg Tablets £19.98
500mg x28 x 500mg Tablets £11.99
500mg x56 x 500mg Tablets £23.98
250mg x28 x 250mg GR Tablets £13.99
250mg x56 x 250mg GR Tablets £19.50
500mg x28 x 500mg GR Tablets £17.99
500mg x56 x 500mg GR Tablets £25.99


Medication Simple Online Pharmacy
500mg/20mg x60 £23.99
Copyright © 2013 - 2024 Simple Online Pharmacy Ltd. All rights reserved.
Data security and protection policies available by request.
  • Digital Clinical
  • LegitScript approved
  • Registed Pharmacy
  • NHS pharmacy
  • Visa
  • mastercard