Authored: 17/10/2021

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and decrease fever. It's commonly used for conditions such as arthritis, muscle aches, and menstrual cramps.
You can buy Naproxen pain relief treatment online using our UK registered online doctor and pharmacy service. An online consultation in the form of an assessment is required to place an order. This can then be evaluated by our GPs who can make sure it is safe and suitable for you to take.
If approved by our doctors, a prescription is sent to our pharmacy team. It is dispensed and dispatched to your chosen delivery address. We use Royal Mail as a courier and have a range of delivery options.
Naproxen is a painkiller medicine that specifically targets inflammatory pains. It belongs to a medicine class known as non-steroidal anti-inflammatory drugs (NSAIDs). Other medicines in this category include ibuprofen, aspirin and diclofenac. Typically people find that Naproxen provides more inflammatory pain relief than ibuprofen or aspirin.
Depending on the pain severity, 250mg or 500mg doses are available. The lowest effective dose should be used to minimise the chance of side effects. Pain and inflammation should be noticeably reduced in 30-60 minutes after taking a dose of Naproxen.
It is only available on prescription, although you can buy it over the counter for period pain and menstrual cramps from a pharmacy under the brand name Feminax Ultra.
It is commonly prescribed for pain relief and to treat inflammation in conditions such as gout, rheumatoid arthritis, sprains and strains and osteoarthritis. Because NSAIDs do not have the potential to cause addiction such as opioid-based painkillers, it is the preferred treatment for those who suffer inflammatory pain. Naproxen (or other NSAIDs) along with paracetamol may make up the base of pain relief treatments before using potentially addictive medicines.
Non-steroidal anti-inflammatories such as Naproxen work by reversibly stopping enzymes in the body responsible for producing an inflammation causing substance known as prostaglandins. Prostaglandins usually signal the body to induce inflammation, by reducing their numbers in the body by slowing their production, inflammation is reduced.
Yes, Naproxen can be taken alongside paracetamol or paracetamol/codeine combinations such as co-codamol. However, it should not be taken with ibuprofen, aspirin, or diclofenac because they are from the same class of medicines (NSAIDs) and will cause increased side effects that may be dangerous.
It is important to note that many other medicines can contain NSAIDs or paracetamol in combination such as cold and flu medicines. This can lead to accidental double doses that can result in side effects. Always ensure you are aware of what is in each medicine you take before use.
As with all pain medicines, it is best to use the lowest effective dose required to avoid the potential side effects of treatments.
You should take it exactly as your doctor has told you to. The dose may vary from person to person depending on why your doctor has prescribed it. The usual Naproxen dosage is to take a dose twice a day with food.
Two strengths are available: Naproxen 250mg and Naproxen 500mg. Your doctor will decide the safest strength and dose for you. Usually, you should take the lowest effective dose for the shortest time. However, some people can be prescribed Naproxen long-term to relieve pain in chronic conditions.
If you have been prescribed Naproxen for a long time, it is important that you are aware of the ways to protect yourself from the potential side effects. Refer to warnings and precautions for more information.
Naproxen is available as regular tablets or as gastro-resistant tablets. The gastro-resistant tablets have a coating that protects them from stomach acid and releases the drug later on in the gut. This can help to protect the stomach from being irritated by the drug.
Dose | Take ONE tablet ONCE or TWICE daily with food as directed |
Type of medicine | NSAID - Non-steroidal anti-inflammatory drug |
Mechanism | Reduces prostaglandins in the body which lead to inflammation |
Available Strengths | 250mg & 500mg |
Active Ingredient | Naproxen |
Price | From £10.94 |
Side Effects | Can include stomach upset, dizziness, headache, nausea. |
250mg x 28 Tablets | £10.94 |
250mg x 56 Tablets | £19.98 |
500mg x 28 Tablets | £11.99 |
500mg x 56 Tablets | £23.98 |
250mg x 28 GR Tablets | £13.99 |
250mg x 56 GR Tablets | £19.50 |
500mg x 28 GR Tablets | £17.99 |
500mg x 56 GR Tablets | £25.99 |
For people unable to take this medicine, paracetamol is a suitable alternative as it can be used by most people. Other NSAIDs available over the counter include ibuprofen, aspirin, and topical diclofenac (Voltarol).
A number of other NSAIDs can be prescribed by your doctor if suitable. Examples include celecoxib, ketoprofen, and mefenamic acid.
As with all medicines, there is a potential for side effects with Naproxen, although not everyone will get them. Common side effects of Naproxen include headache, dizziness, tiredness, and ringing in the ears. You can find more information on common and less common side effects in the patient information leaflet.
When taking this medicine, there are some serious side effects to be aware of. If you notice any stomach problems like indigestion, nausea, stomach pain or vomiting, it may be a sign of a stomach ulcer. If you notice any of these symptoms, speak to your doctor immediately.
Other side effects to mention to your doctor immediately are if you notice black tarry stools or you vomit blood or particles that look like coffee grounds. If this occurs, stop taking naproxen immediately and seek medical advice.
It is important to read the patient information leaflet for further information regarding the potential side effects of treatment.
All of our medication and condition content is written by UK qualified pharmacists and doctors.
Authored: 17/10/2021
Reviewed: 15/12/2024
Before taking any medication, it is important to read the Patient Information Leaflet:
If prescribed naproxen long term, it is important that you are aware of how to protect the stomach while using the medicine. Food should always be consumed before having a dose to protect the stomach from the effect of naproxen. Your doctor may decide to prescribe you a treatment to lower the stomach acid to help further.
It is not suitable for everyone to take. People who have had an allergic reaction to Naproxen or another NSAID should not take it. This includes people with asthma who have found their asthma worsened after taking an NSAID.
People with a history of stomach ulcers or gastrointestinal diseases like Crohn’s or ulcerative colitis should not take Naproxen. People with severe liver, kidney, or heart failure are not able to take Naproxen. For a full list of conditions that can be affected by this medicine, see the patient information leaflet. If you are unsure, talk to your doctor or pharmacist for advice.
Naproxen can interact with a wide variety of medicines. Examples include blood-thinning medicines like warfarin, diuretics, and certain blood pressure medicines. It should also not be taken with other NSAIDs such as aspirin or ibuprofen. This includes low dose aspirin that people are often prescribed after a heart attack or stroke.
Interactions between Naproxen and other medicines can be dangerous and you should check with your doctor if you start any new medication whilst taking this medicine.
Naproxen should not be used within the first 6 months of pregnancy without consultation with a doctor who can assess the risk versus benefit of the treatment. It should NOT be used at all within the last 3 months of pregnancy as it can result in serious complications.
Naproxen does pass into the breastmilk in small amounts. Due to this, it is not recommended to use naproxen during breastfeeding without direct instruction from a doctor.