• Zyban


Medication features

Zyban aids in smoking cessation by easing cravings and withdrawal effects. It provides a nicotine-free route to quitting smoking.

  • Nicotine-Free Treatment
  • Reduces Withdrawal Symptoms
  • Supports Long-Term Success


Buy Zyban Tablets Online UK

You can buy Zyban stop smoking tablets online, from our UK registered online pharmacy and doctor. Before you place your order, you will need to complete an online assessment for our doctors to review. 

If our doctors approve your order, our pharmacy team will dispense and dispatch your medication. Delivery options include next working day delivery. If our doctors feel a face to face consultation would be best for you, a notification is sent via e-mail and a full refund is issued.  

About Zyban

Zyban is an effective treatment for people trying to quit smoking. Zyban helps reduce cravings for nicotine, and can help with withdrawal symptoms as well.

It is a prescription medication that aids in smoking cessation by targeting the brain's nicotine receptors to reduce cravings and withdrawal symptoms. This nicotine-free approach offers a unique advantage for individuals looking to quit smoking without relying on nicotine-based products. It addresses both the physical and psychological challenges of quitting, making the journey towards a smoke-free life more manageable.

By reducing symptoms like irritability and anxiety, Zyban enhances the chance of long-term cessation success. Its effectiveness in helping smokers quit makes it a valuable option for those committed to overcoming tobacco dependence.

How Does Zyban Work?

Zyban uses the active ingredient bupropion, which blocks the receptors that nicotine fills without activating them. This means that you will feel less of the withdrawal effects and cravings on smoking cessation, without worrying about adding another addictive substance into the mix.

Smoking is one of the leading causes of death and illness in the UK. Smoking increases your risk of developing various health problems such as heart disease, stroke, and numerous cancers and lung conditions. Stopping smoking (smoking cessation) is incredibly beneficial for your health and the benefits can start almost immediately

How Effective is Zyban?

Studies have shown that in comparison to smokers trying to quit without assistance, patients using Zyban are twice as likely to be successful in their quit attempt.

Motivation will still play a role in quitting, and you should not expect that Zyban will allow you to quit without any effort. Part of what makes smoking so difficult to kick is the psychological aspects; forming habits and rituals around smoking that can be much more difficult to stop.

However, stop smoking treatment should make it significantly easier to overcome the physical challenges associated with stopping smoking. This can increase your chances of stopping smoking. 

How to Take Zyban

When using Zyban to quit smoking, you should choose a date in the second week of your course on which to stop smoking. This will help prepare you mentally for your quit date, whilst also allowing enough of the medication to be in your system to make the physical symptoms of stopping easier to handle.

Week 1 (taking Zyban while still smoking)Day 1-6One 150mg tablet per day
Day 7Take one tablet twice a day, at least 8 hours apart
Week 2

Keep taking one tablet twice a day

Stop smoking during this week, on your planned day

Weeks 3 to 9

Keep taking one tablet twice a day for up to 9 weeks

If you have not been able to stop smoking by 7 weeks, talk to your doctor about whether Zyban is right for you.

Some people need to take a lower dose, as they may be more likely to get side effects. If you are aged over 65, have liver or kidney disease or a higher risk of seizures, the maximum recommended dose for you is one 150 mg tablet once a day. 

Zyban Side Effects

Like all medications, Zyban can have side effects, although not everyone will experience them. Common side effects include dry mouth, insomnia, headaches, and nausea.

Some people may also experience more serious side effects such as seizures, high blood pressure, or allergic reactions, which require immediate medical attention. It's important for individuals to monitor their health and consult with a healthcare provider if they notice any unusual symptoms or if side effects persist.

Understanding the potential side effects is crucial for anyone considering Zyban as a smoking cessation aid, to ensure they can make an informed decision about their treatment.

Zyban Alternatives

If you cannot take Zyban, or feel like this treatment isn’t as effective, there are alternative options. The main ones are nicotine replacement therapy (NRT) and e-cigarettes.

One example of NRT is nicotine patches - these attach to your skin and deliver controlled doses of nicotine. By gradually reducing the strength of the patches, you can make stopping smoking easier. You can also use nicotine gum/lozenges, either alone or alongside patches if you’re a heavy smoker. Nicotine inhalators/sprays can be used in a similar way to the gum, as a when required dose to reduce your cravings for a cigarette and help you break your smoking habit.

For electronic cigarettes, further research is needed to know more about their benefits in helping people stop smoking. However, the NHS advises that the use of an electronic cigarette is much safer than traditional cigarettes, which contain tobacco.

For more support from the NHS, or to explore your options to stop smoking on the NHS, explore the NHS Quit Smoking site. You can find a full list of prescription medicines available to help stop smoking, as well as other helpful advice.

Zyban Summary

Treatment course9 week course
MechanismReduces nicotine cravings and withdrawal symptoms
Active ingredientBupropion
Side effectsAppetite changes, dry mouth, headaches, abnormal dreams
PriceFrom £68


What is Zyban?

Zyban is a prescription medication used to help smokers overcome the cravings and withdrawal symptoms associated with stopping smoking.

Can you buy Zyban over the counter?

It is not possible to buy Zyban (UK) over the counter. You can buy Zyban online from registered pharmacies and online doctors, but only after completing an online medical assessment. 

You are, however, required to complete an online consultation form which is reviewed by one of our GPs to confirm that the treatment is suitable for you.

How much is Zyban?

Zyban starts at  £68 for 60 tablets.

How long do you take Zyban for?

Zyban is usually taken for 7-9 weeks to give the best chance of quitting smoking.

Can you smoke whilst taking Zyban?

Yes, however, you should ideally set a quit date within 1-2 weeks of taking Champix.

Why is Champix no longer available?

Champix is currently unavailable due to an impurity found in the medication. There is no date for Champix to return in the UK.



Zyban Warnings

Zyban may not be suitable for all people. 

Zyban is not suitable for anyone under the age of 18.

Do not use Zyban if you are pregnant or breastfeeding.

Do not use Zyban if you;

  • Are allergic to bupropion, or any of the listed ingredients
  • Are taking any other medications that contain bupropion
  • Have a seizure condition, such as epilepsy, or have a history of seizures
  • Have an eating disorder, or have had one in the past
  • Have severe liver problems
  • Have a brain tumour
  • Are usually a heavy drinker and have just stopped drinking, or if you plan to stop drinking while using Zyban
  • Have recently stopped taking sedatives or medication to treat anxiety, or if you plan to stop using them while using Zyban
  • Have bipolar disorder
  • Are currently taking MAOIs (to treat depression or Parkinson’s), or have taken them within the last 14 days.

Talk to your doctor before using Zyban. You may be more likely to experience side effects if you have certain medical conditions, including;

  • Brugada syndrome (which affects heart rhythm)
  • A family history of sudden death or cardiac arrest
  • Seizure conditions - Zyban may cause seizures in roughly 1 in 1000 people. Seizures can be more common if;
    • You drink a lot of alcohol
    • You have diabetes
    • You had suffered a traumatic head injury
  • Kidney or liver problems

You may experience more side effects if you are over 65.

In some cases, patients with a history of mental health problems may experience unwanted effects, including hallucinations, delusions, disordered thoughts, extreme mood swings, and thoughts of suicide. If you experience any of these effects, stop using this treatment and speak to your doctor.

Zyban may cause problems when using other medications. If you are currently taking any of the following medications, you may be at a higher risk of seizures;

  • Antidepressants and other mental health medications
  • Theophylline (asthma and lung conditions)
  • Tramadol
  • Malaria treatments
  • Weight loss and appetite suppressant medications
  • Steroids (except creams and lotions)
  • Diabetes medications

Some medications can interact with Zyban, affecting how it works or making you more likely to experience side effects. These include;

  • Cancer treatments (cyclophosphamide, ifosfamide)
  • Ticlopidine or clopidogrel
  • Beta blockers
  • Ritonavir or efavirenz
  • Tamoxifen
  • Digitoxin

For a full list of possible contraindications and medicine interactions, please read the Patient Information Leaflet.

Zyban Side Effects

As with all medications, some patients may experience side effects when using this medication. The most common side effects (affecting 1 in 10 people) can include;

  • Difficulty sleeping
  • Feeling depressed, anxious or agitated
  • Nausea, stomach pain and stomach upset
  • Difficulty concentrating
  • Headache
  • Tremors
  • Fever, dizziness, skin rash, sweating, itching

If you experience any of the following effects, stop using this treatment and seek urgent medical assistance;

  • Seizures or fits (convulsions and loss of consciousness)
  • Allergic reactions (skin rash, swelling of the mouth, lips, eyelids or tongue, pain in joints)
  • Lupus skin rash or worsening of lupus symptoms
  • AGEP (Acute Generalised Exanthematous Pustulosis), which presents as a rash with small pustules on the skin

For a full list of possible side effects, please read the Patient Information Leaflet.


Active Ingredient: bupropion hydrochloride (150mg)

Other Ingredients:

Tablet core - microcrystalline cellulose, hypromellose, cysteine hydrochloride monohydrate,
magnesium stearate.

Tablet coating - hypromellose, macrogol 400, titanium dioxide (E171), carnauba wax.

Printing ink - hypromellose, iron oxide black (E172).

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