Duac Gel
  • Duac Gel
  • Duac Gel

Duac Gel

Medication features

  • Dual action daily gel
  • 3% and 5% strengths
  • Night time application
  • Kills acne causing bacteria


Order Duac Gel Online in the UK

You can request to order Duac dual action acne gel online from our UK registered online pharmacy and doctor service. As part of your order, you need to complete an online consultation for our doctors to review.  

If approved, a prescription is passed to our pharmacy team who will then dispense and dispatch the medicine to your chosen address using Royal Mail. The prescription fee is calculated into the Duac Gel cost.

What is Duac?

Duac Once Daily Gel is a commonly prescribed and effective topical treatment for acne. It is used in cases of mild to moderate acne which have not responded to antibiotics or peeling agents alone. It contains two active ingredients that are effective against acne: clindamycin and benzoyl peroxide. 

It is available in two different strengths: Duac 5% and 1% or Duac 3% and 1%.

How does Duac work?

The gel has a dual mechanism of action. Clindamycin is an antibiotic that works to kill bacteria that grow on the skin and can exacerbate spots and zits.

Meanwhile, benzoyl peroxide helps to prevent pores on the skin from becoming blocked. Blocked pores can often lead to spots and zits due to infection. By reducing blocked pores and decreasing the chance of blocked pores becoming infected, the gel is an effective treatment in reducing the appearance of red and inflamed spots in people who suffer from acne.

Is Duac Gel effective?

Duac contains two active ingredients which can work in different ways to improve acne symptoms. However, it can take between 2 to 5 weeks before a beneficial effect is seen and it should not be used for more than 12 weeks at a time.

How is Duac Gel applied?

The gel is usually applied to the affected area in the evening, after washing your face. 

Remember when washing your face, you should use warm water, and ideally an oil-free acne wash. Patting your skin dry is also preferable because this is less irritating to your skin. After washing, apply it thinly over the affected areas with your fingertips. Wash your hands before and after applying the gel.

Some patients will experience some skin peeling and redness during the first few weeks of treatment. If you find your skin is irritated, you can stop using it for a short period or apply it less often. You could also try an oil-free moisturiser to improve the irritation.

What alternatives are there to Duac? 

Before using Duac or any prescription treatment, you can try over the counter products first. These may be enough to control your acne.

One of the most common ingredients in pharmacy treatments for acne is benzoyl peroxide. This can be bought over the counter at a pharmacy, for example, the branded gel Acnecide. This is also available as a wash.

If over the counter treatments are unsuccessful, you can also use other antibiotic based acne treatments such as oral Lymecycline or topical Zineryt. Retinoid based treatments such as Differin cream and Epiduo gel are also available and are commonly prescribed by GPs to treat acne.

Duac Gel Summary


Apply ONCE in the evening after washing your face


Kills acne-causing bacteria and prevents pore blockage

Active Ingredients

Clindamycin and Benzoyl peroxide


from £18.50

Side Effects

Can include skin dryness, redness, irritation and itching

Duac Gel Prices

3% - 30g


3% - 60g


3% - 90g


5% - 30g


5% - 60g


5% - 90g


Content Reviewed: 17/03/21


When should I use Duac?

If your acne has not responded to antibiotics or peeling agents alone, then Duac may be suitable for you. It provides a second line of treatment for more resistant acne.

What does Duac do?

Duac works in two ways to help reduce acne symptoms. It kills bacteria on the surface of the skin and also helps prevent clogged pores that can become infected.

What are the side effects of Duac?

The most common side effect is dry, red or sore skin. This is because Benzoyl Peroxide has a drying effect on the skin. If inflammation and dryness are severe, you should reduce the application frequency to once every two days.  If you are still suffering from severe dry/red skin, you should stop using this treatment. You may also notice you have increased sensitivity to light. Wearing protective clothing/sunscreen is recommended if you notice your skin is more sensitive to sunlight.

Can I use Duac gel more than once daily?

There is no evidence to suggest that using Duac Gel twice daily will clear acne more effectively. Overuse is likely to result in skin dryness and irritation and may lead to antibiotic resistance.

Can I apply more Duac Gel?

No there is no evidence to suggest that applying more gel (i.e. not thinly) will improve acne treatment and can lead to resistance.

How long does Duac take to work?

Most people will see an effect within 2 to 6 weeks of using Duac gel consistently.

Can I buy Duac online?

Duac Gel, in the UK, is a prescription-only medicine that cannot be bought over the counter. However, you can request it from our UK registered pharmacy and online doctor service. One of the ingredients in Duac, Benzoyl peroxide, is available to buy over the counter but for the other, clindamycin, buying online in the UK is not possible. We ask that you complete an online assessment form, which is reviewed by our doctors. If your treatment is approved, our online doctors will send a prescription to our pharmacy team. From here, it is delivered to your chosen address. Duac gel is sometimes referred to as Duac spot cream or Duac face cream.


Treatment Comparison

IngredientsClindamycin / Benzoyl PeroxideAdapaleneLymecycline
ActionDual action on bacteria; antibiotic and skin sheddingHelps unblock pores and reduce inflammationAntibiotic kills bacteria
Oral or Topical?TopicalTopicalOral
DirectionsApply thin layer at night after washing.Apply thin layer at night after washing.Take ONE capsules DAILY (preferably in the morning)

Side Effects

Duac Side Effects

Side effects usually occur on the skin. The most common side effects are dry skin, redness, irritation, and itching. 

These side effects are a result of benzoyl peroxide, which has a drying effect on the skin. If these side effects are problematic, you may find applying the gel once every two nights may still be effective, yet lessen the irritation experienced. If the redness or inflammation is severe, you should stop treatment and see your GP.

Less commonly, it can cause stomach upsets and in rare cases, you may experience bad diarrhoea. Stop using this treatment immediately and speak to your GP if you develop severe diarrhoea after using it. As Duac contains an antibiotic, it should not be used with other antibiotic treatments because this will increase the likelihood of this side effect.

See the patient information leaflet for further details on side effects.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at medicines.org, or by contacting us.



Duac can cause your skin to become sensitive to sunlight. As a precautionary measure, you should wear sunscreen and hats to avoid exposure to direct sunlight.

If you are pregnant or breastfeeding, you should avoid using the gel unless on specific advice from a dermatologist.

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Medication Simple Online Pharmacy
Gel x2 x 45g £55.98
Gel x1 x 45g £28.99
Cream x2 x 45g £47.95
Cream x1 x 45g £24.95

Lymecycline (Generic) | Tetralysal 408mg

Medication Simple Online Pharmacy
Tetralysal (Brand) x56 £22.50
Tetralysal (Brand) x28 £14.95
Lymecycline (Tetalysal Generic) x56 £21.95
Lymecycline (Tetalysal Generic) x28 £14.50

Oxytetracycline 250mg Tablets

Medication Simple Online Pharmacy
1 Month Supply (112 Tablets) £14.99

Duac Gel

Medication Simple Online Pharmacy
5% x3-x-30g £54.99
5% x2-x-30g £36.49
5% x1-x-30g £18.50
3% x3-x-30g £54.99
3% x2-x-30g £36.49
3% x1-x-30g £18.50

Zineryt Solution

Medication Simple Online Pharmacy
30mls £14.95
Zineryt x 90mls £32.95

Epiduo Gel

Medication Simple Online Pharmacy
Epiduo Gel x1 x 45g £25.95
Epiduo Gel x2 x 45g £45.95
Epiduo Gel x3 x 45g £68.95


Medication Simple Online Pharmacy
20% x30g £14.99