Duac Gel
  • Duac Gel

Duac Gel

Medication features

  • Dual action daily gel
  • 3% and 5% strengths
  • Night time application
  • Kills acne causing bacteria


Duac Gel UK

You can request to buy Duac dual action acne gel online from our UK registered online pharmacy and doctor service. To see if you are suitable for this treatment, complete the online assessment and checkout. Our UK registered doctors will review the order, and if approved, pass a prescription to the pharmacy team. We will then dispense and dispatch your order to your chosen address.

What is Duac?

Duac gel is a commonly prescribed and effective topical treatment for acne. It is used in cases of mild to moderate acne which have not responded to antibiotics or peeling agents alone. It has two ingredients which combine both of the main acne treatments. These are;

  1. Clindamycin – Clindamycin is an antibiotic and is perhaps the most commonly used antibiotic for acne.
  2. Benzoyl peroxide – This is a peeling agent which works to remove blockages of excess sebum from the skin pores. In addition, benzoyl peroxide also has an anti-bacterial action.

How Does Duac Work?

Duac has a dual mechanism of action. Clindamycin is an antibiotic which works to kill bacteria which grows on the skin and can exacerbate spots and zits. Meanwhile, the benzoyl peroxide in Duac helps prevents pores on the skin becoming blocked. Blocked pores can often lead to spots and zits due to infection. By reducing the number of blocked pores and decreasing the chance of blocked pores becoming infected, Duac is an effective treatment in reducing the appearance of red and inflamed spots in people who suffer from acne.

What alternatives are there to Duac? 

Before using Duac or any prescription treatment, you should try over the counter products first, as these may be enough to control your acne. One of the most common ingredients in pharmacy treatments for acne is benzoyl peroxide. As discussed, this helps prevent acne by killing skin bacteria and stopping the pores of your skin from getting blocked. An example of a pharmacy acne gel is Acnecide. This is available as both a gel, and a wash.

A good self care guide for acne is available from the British Skin Foundation.

If over the counter treatments are unsuccessful, you can also use other antibiotic based acne treatments such as Lymecycline and Zineryt. Retinoid based treatments such as Differin and Epiduo gels are also available and are commonly issued by GPs to treat acne.


Duac FAQ

How Is Duac Applied?

The gel is usually applied to the affected area in the evening, after washing your face. Remember when washing your face, you should use warm water, and ideally an oil-free acne wash. Patting your skin dry is also preferable, as this is less irritating to your skin. Following washing, apply Duac thinly over all affected areas with your fingertips.

When should I use Duac?

If your acne has not responded to antibiotics or peeling agents alone, then Duac combines both, to provide a second line of treatment to more resistant acne.

What does Duac do?

Duac works in two ways to help reduce acne symptoms. It kills bacteria on the surface of the skin, and also helps prevent clogged pores which can become infected.

What are the side effects of Duac?

The most common side effect of Duac is dry, red or sore skin. This is because Benzoyl Peroxide has a drying effect on the skin. If inflammation and dryness are severe, you should reduce the application frequency to once every two days. If you are still suffering from severe dry/red skin, you should stop using this treatment. You may also notice you have increased sensitivity to light. Wearing protective clothing/sunscreen is recommended if you notice your skin is more sensitive to sunlight

Can I use Duac gel more than once daily?

No there has not been any convulsive evidence to suggest that using Duac Gel twice daily will clear acne more effectively. Overuse is likely to result in skin dryness and irritation and may lead to antibiotic resistance.

Can I apply more Duac Gel?

No there is no evidence to suggest that applying more Duac gel (i.e. not thinly) will improve acne treatment and can lead to resistance.

How long does Duac take to work?

Most people will see an effect within 2 to 6 weeks of using Duac gel consistently.


Treatment Comparison

IngredientsClindamycin / Benzoyl PeroxideAdapaleneLymecycline
ActionDual action on bacteria; antibiotic and skin sheddingHelps unblock pores and reduce inflammationAntibiotic kills bacteria
Oral or Topical?TopicalTopicalOral
DirectionsApply thin layer at night after washing.Apply thin layer at night after washing.Take ONE capsules DAILY (preferably in the morning)

Side Effects

Side effects of Duac

Duac side effects usually occur on the skin. The most common side effects experienced when using the gel are

  • skin dryness
  • redness /irritation/itching

These side effects are as a result of the benzoyl peroxide which has a drying effect on the skin. If these side effects are problematic, you may find applying the gel once every two nights may still be effective, yet lessen the irritation experienced. If the redness or inflammation is sever, however, you should discontinue treatment and see your GP.

Less commonly, Duac can cause stomach upsets and in rare cases, you may experience bad diarrhoea. Stop using this treatment immediately and speak to your GP if you develop severe diarrhoea after using Duac. As Duac contains an antibiotic, it should not be used with other antibiotic treatments, as this will increase the likelihood of this side effect.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at medicines.org, or by contacting us.


Cautions when using Duac

Duac can cause your skin to become sensitive to sunlight. As a precautionary measure, you should wear sunscreen and hats to avoid exposure to direct sunlight. 

If pregnant or breastfeeding, you should avoid using Duac unless on specific advice from a dermatologist. 

Order within for guaranteed next day delivery options


£18.50 - £54.99
Quantity 1-x-30g - 3-x-30g

The above pricing is for indicative purposes only.

£18.50 - £54.99
Quantity 1-x-30g - 3-x-30g

The above pricing is for indicative purposes only.

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Medication Simple Online Pharmacy
Gel x2 x 45g £55.98
Gel x1 x 45g £28.99
Cream x2 x 45g £47.95
Cream x1 x 45g £24.95

Lymecycline (Generic) | Tetralysal 408mg

Medication Simple Online Pharmacy
Tetralysal (Brand) x56 £22.50
Tetralysal (Brand) x28 £14.95
Lymecycline (Tetalysal Generic) x56 £21.95
Lymecycline (Tetalysal Generic) x28 £14.50

Oxytetracycline 250mg Tablets

Medication Simple Online Pharmacy
1 Month Supply (112 Tablets) £14.99

Duac Gel

Medication Simple Online Pharmacy
5% x3-x-30g £54.99
5% x2-x-30g £36.49
5% x1-x-30g £18.50
3% x3-x-30g £54.99
3% x2-x-30g £36.49
3% x1-x-30g £18.50

Zineryt Solution

Medication Simple Online Pharmacy
Zineryt x 30mls £14.95
Zineryt x 90mls £32.95

Epiduo Gel

Medication Simple Online Pharmacy
Epiduo Gel x1 x 45g £25.95
Epiduo Gel x2 x 45g £45.95
Epiduo Gel x3 x 45g £68.95