• Premique


Medication features

  • Treats symptoms of the Menopause
  • Balances level of oestrogen in the body
  • Contains medroxyprogesterone acetate


Order Premique Low Dose HRT Tablets Online

You can order Premique online from our UK registered online pharmacy and doctor service. After completing an online questionnaire, it will be reviewed by our UK doctors. They will assess whether the medicine is appropriate for you. If approved by our doctors, our pharmacy team will dispense the medicine and dispatch it to your chosen address.

What is Premique Low Dose?

Premique Low Dose is a Hormone Replacement Therapy (HRT). It is used to treat symptoms associated with the menopause

Premique Low Dose contains two types of hormones:

  • Oestrogens
  • A progestogen called medroxyprogesterone

Premique Low Dose is known as a continuous combined HRT because it contains both oestrogen and progestogen. It is a period-free HRT, meaning it does not produce a monthly bleed like other types of HRT.

How does it work?

The oestrogen level in the body drops during the menopause. This reduction can cause menopausal symptoms such as night sweats, hot flushes, mood changes, sex drive changes, vaginal dryness, sleep disturbance and muscle aches.

Premique tablets replace the oestrogen lost during the menopause which improves menopausal symptoms. Increasing oestrogen levels can increase the risk of womb cancer by causing overgrowth of the womb lining. Premique contains a progestogen which helps to protect against this increased risk.


The dose for Premique is one tablet once a day. This is taken continuously with no break between packs.

If you forget or miss a tablet, take it as soon as you remember and continue as normal. If more than one tablet is missed, do not take any extra tablets to make up for the missed doses.


Other forms of HRT include:

  • Vaginal creams
  • Vaginal pessaries
  • Vaginal rings
  • Topical gels
  • Skin patches

Our doctors are able to prescribe a number of HRT products on our website:

  • Kliovance
  • Livial
  • Premarin
  • Provera
  • Trisequens
  • Elleste Duet
  • Elleste Duet Conti
  • Elleste Solo
  • Evorel Conti patches
  • Evorel Sequi patches

A number of HRT products have suffered from product shortages in the past two years. Many products have slight differences, making it hard to find a direct alternative when one becomes unavailable to stock. 

There is no direct alternative to Premique Low dose, the closest alternative would be to take another continuous combined HRT product such as Kliovance or Femoston.


What is Premique?

Premique is a Hormone Replacement Therapy (HRT) used to treat the symptoms of menopause. The active ingredients are oestrogen and progestogen hormones.

Is Premique available?

Premique Low Dose tablets are available on our website. Another strength of Premique, called Premique 0.625mg/5mg, was previously on the market but is no longer produced. 

How long does Premique take to work? 

The full effects of HRT can take up to three months to show but some women may notice benefits within a few weeks of starting therapy.

Does HRT help anxiety?

Low mood and anxiety can be symptoms of the menopause. Some women may find HRT improves anxiety associated with the menopause. However, some HRT products list anxiety as a side effect. Premique mentions anxiety to be an uncommon side effect of treatment.

How quickly does HRT stop flushes?

As mentioned above, the beneficial effects of HRT may only become apparent up to three months after starting treatment. For some women, HRT may alleviate symptoms like hot flushes within a few weeks. 

Can I request HRT online?

Premique can be prescribed online. Before prescribing HRT, UK registered doctors on our website need to assess each patient. 

After completing an online questionnaire, if deemed suitable by our doctors, a prescription will be issued. Our pharmacy team can then dispatch your medication. Our price includes the consultation, prescription and dispensing. Delivery options are available at checkout.

Side Effects

There is always a risk of side effects when taking any medicine. 

Common side effects of Premique Low Dose include:

  • Breast pain, tenderness and discharge
  • Leg cramps
  • Weight changes
  • Depression
  • Breakthrough bleeding or spotting

Some women can experience breakthrough bleeding or spotting at the start of treatment. If it is severe or it continues after 3 months of starting Premique, discuss this with your doctor immediately. The patient information leaflet contains further information on side effects.

Women should be aware of the potential risks of HRT before starting therapy. Women taking HRT report the following diseases more often than women who do not take HRT:

  • Endometrial cancer (the progestogen in Premique mitigates this risk)
  • Stroke
  • Heart disease
  • Ovarian cancer
  • Breast cancer
  • Blood clots (venous thromboembolism)

The risk of having a stroke is about 1.5 times higher in HRT users than in non-users. The risk of stroke due to HRT use increases with age.

The risk of blood clots in HRT users is up to 3x higher than in non-users. The risk is highest during the first year of treatment. 

The increased risk of breast cancer means that, out of 1000 women using HRT, 4-6 extra women in a 5 year period will be diagnosed with breast cancer compared to non-users of HRT.

HRT users should attend regular checkups with their doctor to monitor treatment efficacy and side effects. The NHS website contains information on the symptoms of blood clots, breast cancer, endometrial cancer and stroke as well as information on the risks of HRT.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at, or by contacting us.


Other conditions and Premique

It is important to mention any medical conditions you have during the online questionnaire. Premique must not be taken if you:

  • Are allergic to any of the ingredients in Premique
  • Have or have ever had a blood clot
  • Have endometrial hyperplasia (a thickening of the womb lining)
  • Have had recent angina, stroke or heart attack
  • Have or have ever had breast cancer
  • Have any blood clotting disorders
  • Have or have ever had cancer sensitive to oestrogens (such as womb cancer)
  • Are currently pregnant or breastfeeding
  • Have or have ever had liver disease
  • Have unexplained vaginal bleeding

If you develop any of these during treatment you must stop taking Premique and speak to healthcare professionals like your GP or pharmacist immediately.

Interactions with other medicines

When completing the online questionnaire, make sure to list any medicines you currently take. Premique should be used in caution with a number of medicines. These include:

  • Anti-epileptic medicines like carbamazepine
  • Medicines to treat tuberculosis
  • Anti-HIV medicines
  • St John’s Wort (a herbal medicine)
  • Metyrapone and aminoglutethimide (used in Cushing’s syndrome)

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