• Mebeverine MR
  • Mebeverine


Medication features

  • For IBS
  • The brand name is Colofac
  • Take ONE three times daily


Order Mebeverine 135mg Tablets Online

You can request to order Mebeverine online from our UK registered online pharmacy and doctor service. After completing an online assessment, our doctor will review your order and make sure the medication is suitable for you. 

If approved, a prescription will be passed to our pharmacy team who will dispense and dispatch the medicine to your chosen delivery address. Next working day delivery options are available.

We have checked our prices against our competitors and are amongst the cheapest online for all treatments. Please note, there are no prescription fees and no delivery charges on orders over £45.

How does Mebeverine work?

Mebeverine 135mg is a treatment for the medical condition Irritable Bowel Syndrome (IBS). This is the active ingredient in the well known IBS medication Colofac. It belongs to a group of medicines called anticholinergics.  

Irritable Bowel Syndrome can cause spasms and pain in the gut and intestines. Mebeverine tablets work by relaxing the muscles in and around the gut to relieve these spasms. By doing so, it can provide relief from the pain and cramping caused by the spasms.

It is a well-tolerated medication which is used extensively in the treatment of IBS. The branded version is called Colofac.

How do you take Mebeverine?

The usual recommended Mebeverine dose is one tablet three times a day, but your doctor may advise you to take less. Tablets should be swallowed with a glassful of water and ideally taken about 20 minutes before a meal.

Mebeverine is also available as modified-release capsules. These are usually taken twice daily. 

Alternatives to Mebeverine

There are many treatments available for IBS. Other treatments include: 

Apart from cramps and stomach pain, IBS can also cause symptoms like diarrhoea and constipation. Anti-diarrhoea medication, like Imodium, can be useful when your IBS causes diarrhoea. Likewise, laxatives such as Fybogel can help to improve constipation symptoms.

For more advice on treatments for different symptoms of IBS, talk to your doctor or pharmacist.

Mebeverine Reviews

Some people may be worried when switching from Colofac to Mebeverine that the generic form of the drug will not work as well. Many of our patients review the medications they purchase from the site. Just click on the "Reviews" tab, to see how other people have found using the medicine.

Mebeverine Summary


Take ONE tablet THREE times a day, about 20 minutes before meals


Relaxes the muscles in and around the gut to relieve gut spasms

Active Ingredient



from £9.95

Side Effects

Can include itching, rash, hives

Mebeverine Prices

135mg x 100


135mg x 200



  • What is Mebeverine?

    It is a medicine used to treat Irritable Bowel Syndrome (IBS). It is called an antispasmodic medicine because it relaxes the muscles in the digestive system.

    It is an antispasmodic drug used to treat the symptoms of Irritable Bowel Syndrome (IBS). It is available on prescription and over the counter at certain pharmacies. The branded version is called Colofac. The active ingredient is mebeverine hydrochloride.

  • Can Mebeverine help constipation?

    The tablets help with stomach pain and cramps that are caused by muscle spasms. These are common symptoms of IBS but constipation is another common symptom. Unfortunately, Mebeverine does not treat constipation. Laxatives such as Fybogel can be used to treat constipation.

  • Is Mebeverine the same as Buscopan?

    Buscopan is different from Mebeverine. Buscopan contains the active ingredient hyoscine which works differently, but can also help to relieve muscle spasms in IBS.

  • How quickly does Mebeverine work?

    It should start to help symptoms around one hour after taking a dose.

  • What is Mebeverine used for?

    As well as treating IBS, it is used to treat a number of other conditions. These include chronic irritable colon, mucous colitis, spastic colitis and spastic constipation. It helps to treat the symptoms associated with these conditions such as abdominal pain and cramps and flatulence.

  • How many Mebeverine can I take a day?

    The maximum amount of tablets you can take a day is three. One tablet should be taken three times a day.


  • How can I cure IBS permanently?

    Unfortunately, there is no cure for IBS and for many people it is a lifelong problem. However, using effective medicines such as Mebeverine can help to ease symptoms. There are many important lifestyle changes you can make that can help your IBS. This includes simple tips such as not skipping or delaying meals and not eating too quickly.

  • Can I buy Mebeverine over the counter?

    Mebeverine, in the UK, is available from certain pharmacies over the counter. The smaller pack size of Colofac, for example, can be bought after a discussion with a pharmacist.  

    You can also request to order it online from registered online doctor services such as ours at Simple Online Pharmacy. Our doctors ask you to complete an online medical assessment as part of your order. This is then assessed and, if approved, our pharmacy team will dispense the medicine to your chosen address.

    Content Reviewed: 02/02/21


Treatment Comparison

ColperminColofac / MebeverineFybogel Mebevine
Active Ingredients0.2ml Peppermint OilMebeverineMebeverine / Ispaghula Husk.
MechanismUnclearAnti-spasmodic.Anti-spasmodic and bulk forming laxative
DosageONE capsule THREE times dailyNormal Release: Take ONE THREE times daily --- Slow Release - Take ONE tablet TWICE daily.Usually ONE sachet TWICE daily

Side Effects

Mebeverine Side Effects

What are the side effects of Mebeverine?

As with any medicine, it can cause unwanted side effects, although not everybody gets them.

It can cause mild allergic symptoms like an itchy skin rash, hives or inflamed skin. In rare cases, it may cause a severe allergic reaction which requires urgent medical attention. If you notice signs of a severe allergic reaction such as wheezing, a swollen tongue or throat, and difficulty breathing - seek medical attention immediately.

See the patient information leaflet for further details.


Info Leaflet

You can read the patient information leaflet for mebeverine online, at

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Medication Simple Online Pharmacy
300 £43.95
200 £31.95
100 £16.95


Medication Simple Online Pharmacy
200mg M/R Capsules (Twice Daily) x120 £17.95
200mg M/R Capsules (Twice Daily) x60 £10.95
135mg Tablets (Three Times Daily) x200 £21.95
135mg Tablets (Three Times Daily) x100 £12.95

Fybogel Mebeverine

Medication Simple Online Pharmacy
Fybogel Mebeverine x 10 Sachets £6.75


Medication Simple Online Pharmacy
135mg tablets three times daily x100 £9.95
135mg tablets three times daily x200 £18.95
200mg MR capsules x60 £9.95
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