• Omeprazole


Medication features

  • Short term (4-5 day) Treatment
  • ONCE or TWICE daily as required
  • See GP if symptoms persist


Omeprazole Tablets Online

You can order Omeprazole for acid reflux from our UK registered online pharmacy and doctor service. No prescription is required, however, you will need to complete an online assessment, so our doctors can issue a prescription to our pharmacy. If the doctors approve your order, a prescription is passed to our pharmacy, which will then dispense and dispatch your medication.

About Omeprazole

Omeprazole is a drug that reduces the amount of acid the stomach makes. It is a proton pump inhibitor (PPI). It can be used to treat a number of conditions. It is most often used to treat indigestion and heartburn/acid reflux.

Acid reflux, also known as heartburn, occurs when stomach acid travels up the gullet (oesophagus) to the throat. This can cause a burning sensation in the chest and leave an unpleasant taste in the back of the mouth. If acid reflux continues long term, it is called gastroesophageal reflux disease (GERD or GORD).

Indigestion, also called dyspepsia, is discomfort in the stomach that can cause you to feel bloated or sick. Acid reflux is also a symptom of indigestion.

Omeprazole is very commonly used to treat these conditions and is effective at improving symptoms of heartburn and indigestion.

Acid reflux can sometimes be caused by serious diseases. Please see your GP if:

  • Lifestyle changes or over the counter medicines do not improve symptoms
  • Symptoms persist longer than 5 days despite taking omeprazole
  • You have heartburn frequently for 3 weeks or more
  • There are other symptoms, like food getting stuck in the throat, being sick often or unintended weight loss

Your GP can run tests to rule out serious causes of acid reflux.

When filling out our online form make sure to list all of your symptoms, even if they do not seem linked to acid reflux.

Omeprazole can also be used for:

  • Erosive esophagitis (stomach acid can damage the oesophagus long term)
  • Zollinger ellison syndrome
  • Stomach ulcers
  • H.Pylori stomach infections (omeprazole is taken for 7 or 14 days alongside antibiotics)

Certain factors can cause or worsen acid reflux and indigestion:

  • Fatty, rich or spicy foods
  • Caffeinated drinks, such as coffee or fizzy drinks
  • Alcohol
  • Being overweight
  • Smoking
  • Stress
  • Certain medications, such as ibuprofen


Top 5 Ways to Combat Acid Reflux

How does omeprazole work?

The lining of the stomach contains proton pumps. These pump acid into the stomach to help digest food. Acid reflux is caused by this acid travelling from the stomach to the gullet and sometimes to the throat.

Omeprazole is a proton pump inhibitor. This means it stops the proton pumps producing acid. This reduces the amount of acid in the stomach and improves indigestion and heartburn symptoms.

Omeprazole is very effective at reducing the amount of acid produced by the stomach. This makes it an effective treatment for acid reflux.

Omeprazole capsules are delayed release to make sure the medication enters the bloodstream.

Omeprazole capsules are available in strengths of 10mg or 20mg. Our doctors can also prescribe orodispersible versions of omeprazole under the brand name Losec MUPS. It can also come as an oral suspension. These are useful if a patient has difficulty swallowing capsules.

Omeprazole Summary

Omeprazole Dosing

Take ONE capsule in the morning or as directed.


Reduces stomach acid, improving heartburn and indigestion symptoms


From £9.95

Side effects

Can include stomach pain, nausea, headache, diarrhoea.

Omeprazole Prices

Omeprazole 10mg x 28 capsules


Omeprazole 10mg x 56 capsules


Omeprazole 20mg x 28 capsules


Omeprazole 20mg x 56 capsules


Omeprazole Alternatives

There are several other prescription and non-prescription treatments for acid reflux. The other most common prescription treatments are:

Over the counter treatments for acid reflux work by creating a barrier on top of the stomach to prevent acid reflux. These treatments include:

Certain lifestyle changes can be used alongside omeprazole or other medications to improve symptoms: 

  • Avoid eating 3 hours before bedtime
  • Eating smaller meals
  • Losing weight if overweight
  • Raising the head of the bed (so your chest is above the level of your waist)


  • What is Omeprazole?

    Omeprazole is a medication used for people suffering from heartburn and indigestion caused by excess acid production. It is in a class of drug called proton pump inhibitors (PPIs)

  • How does Omeprazole work?

    Omeprazole works by reducing the amount of acid your stomach produces. As heartburn and reflux is often caused by excess acid, this helps control the symptoms that people feel.

  • How long should I take Omeprazole for?

    Without seeing a GP for a check-up, Omeprazole should only be taken for 4-5 days to help control acid reflux. If your symptoms persist, this may be indicative of a more serious condition, and you should see your GP for a full checkup.

  • At what time of the day should I take Omeprazole?

    Omeprazole should be taken in the morning approximately 30 minutes prior to breakfast.

  • Can Omeprazole be taken in pregnancy?

    Yes, omeprazole can be taken in pregnancy.

  • Can Omeprazole be taken whilst breastfeeding?

    Can, Omeprazole be taken whilst breastfeeding?

  • Can Omeprazole affect my ability to drive?

    It is possible, however, is unlikely that this medication will affect your ability to drive. If it does make you feel dizzy or causes a visual disturbance, do not drive.

  • Can you take an Antacid with Omeprazole?

    No, Omeprazole should be taken approximately 30 minutes to an hour before antacids.

  • How long does it take to work?

    Omeprazole should work quickly for heartburn although this varies between patients. Some people find symptoms improve after the first dose although it can take up to 4 weeks for the full effect to be seen. If symptoms have not improved after 5 days of taking omeprazole, talk to your doctor/GP.

  • How do I take omeprazole?

    Swallow the capsule whole with a glass of water. The capsule should not be crushed or chewed.

    Omeprazole is usually prescribed as a once-daily dose, taken in the morning. Sometimes a twice-daily dose is prescribed. In this case, doses should be taken 12 hours apart (morning and night).

    If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose. If this happens, skip the missed dose and take the remaining capsules as normal. A double dose should not be taken.

  • Can I take omeprazole with other heartburn medication?

    Antacids like Gaviscon can be used with omeprazole but should be taken at least 2 hours after omeprazole. If you find you need to use an antacid often while taking omeprazole, please speak to your doctor or pharmacist. Apart from antacids, do not take other heartburn medication with omeprazole.


Treatment Comparison

Omeprazole / LosecRanitidine / Zantac
IngredientOmeprazole 10 or 20mgRanitidine 150 or 300mg
Mechanism of ActionPPI - reduces acid in stomachH2 Blocker - reduces acid in stomach
Common Side EffectsDiarrhoea, headache, nausea, and vomiting.Diarrhoea, headache, nausea, and vomiting.
DosageOne tablet up to twice daily as requiredOne tablet up to twice daily as required

Side Effects

Side effects of Omeprazole

As with all medications, there are some side effects, although not everybody gets them. Some of the side effects associated with Omeprazole are stomach pain, headache, diarrhoea and nausea.

A full list of side effects can be seen in the patient information leaflet and it is always advised you read this prior to taking any medication.

If omeprazole is taken long term (over 1 year) it can increase the risk of certain side effects:

  • Magnesium deficiency (can occur after 3 months of treatment)
  • Bone fractures or joint pain
  • Vitamin B12 deficiency
  • Gut infections (increased risk of clostridium difficile)

Your GP may want to monitor you more closely if you take omeprazole long-term.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at, or by contacting us.


Omeprazole Dosage


Omeprazole 10mg and 20mg

Omperazole Dose

The most common dosage is ONE tablet / capsule first thing in the morning. May be taken with or without food.

If your GP has advised twice daily dosage, you may take ONE both morning and evening.

The usual starting dose in 10-20mg once daily, increasing up to 20mg twice daily if advised.


Omeprazole Warnings and Precautions

Interactions with other medication

When filling out our online form, make sure to list any medication you currently take.

Some drugs interact with omeprazole and may cause side effects or reduce how well one or both medications work. 

Omeprazole may reduce the effectiveness of the blood thinner clopidogrel. Patients who take clopidogrel should be prescribed a different PPI such as lansoprazole.

Other medicines which may interact are listed below:

  • Medications for HIV
  • Methotrexate (used to treat autoimmune disease and cancer)
  • Ketoconazole, itraconazole, rifampicin (used to treat infections)
  • Digoxin (used to treat heart problems)
  • Warfarin (used as a blood thinner)
  • Other medication for heartburn such as antacids

Other conditions and omeprazole

When filling out our online form, make sure to mention any medical conditions that you have.

Omeprazole may not be safe for everyone, especially those who:

  • Have had an allergic reaction to omeprazole or any other medicines in the past
  • Have liver disease
  • Are due to have an endoscopy
  • Have B12 deficiency or magnesium deficiency

Order on Monday to Friday until 3:30pm guarantees next day delivery options


Prices From £9.95
As low as £0.27 / Tablet

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Medication Simple Online Pharmacy
20mg x56 - Capsules £15.95
20mg x28 - Capsules £10.95
10mg x56 - Capsules £14.95
10mg x28 - Capsules £9.95

Ranitidine 150mg Tablets

Medication Simple Online Pharmacy
60 - Tablets (150mg) £14.95
30 Tablets (150mg) £9.95


Medication Simple Online Pharmacy
15mg x28 £16.95
15mg x14 £11.95
30mg x14 £12.95
30mg x28 £17.95
15mg Orodispersible x28 £24.95
15mg Orodispersible x14 £14.95
30mg Orodispersible x14 £16.95
30mg Orodispersible x28 £26.95


Medication Simple Online Pharmacy
20mg x56 - Capsules £32.99
20mg x28 - Capsules £18.99
10mg x28 - Capsules £14.99

Losec MUPS Tablets

Medication Simple Online Pharmacy
20mg x28 - Tablets £28.99


Medication Simple Online Pharmacy
20mg x14 £13.50
20mg x28 £16.50
20mg x56 £19.50
20mg x112 £29.50
40mg x14 £14.50
40mg x28 £17.50
40mg x56 £20.50
40mg x112 £31.50


Medication Simple Online Pharmacy
20mg x14 £12.50
20mg x28 £18.50
20mg x56 £22.50
20mg x112 £29.50
40mg x14 £13.50
40mg x28 £19.50
40mg x56 £23.50
40mg x112 £30.50


Medication Simple Online Pharmacy
10mg x14 £11.50
10mg x28 £16.50
10mg x56 £19.50
10mg x112 £33.50
20mg x14 £12.50
20mg x28 £17.50
20mg x56 £20.50
20mg x112 £34.50