• Colofac


Medication features

  • Standard release or modified release available
  • IBS Treatment
  • Contains Mebeverine 135mg
  • One tablet three times daily


Order Colofac Tablets For IBS Online

You can request to buy Colofac for IBS online, from our UK registered online pharmacy and doctor service. After completing your assessment and checking out, your order will be passed to our UK registered doctors for review. If approved, our pharmacy team will dispense and dispatch your medication to your chosen address.

About Colofac

Colofac is a medication used in the treatment of irritable bowel syndrome (IBS). It contains the active ingredient mebeverine hydrochloride, which works by relaxing the muscles in and around the gut. This helps to relieve spasming symptoms caused by IBS. It is a well-tolerated medication that is used extensively in the treatment of patients with IBS. 

It is available as both the normal release tablets or modified-release tablets (Colofac MR).

How does Colofac work?

IBS can cause muscle spasms in the intestines and can lead to symptoms like abdominal pain and cramps. The active ingredient in Colofac tablets, mebeverine, relaxes the muscles in the intestines to relieve spasms and cramps.

Colofac alternatives

There are other treatment options available if this medicine is not right for you. You can request to order these from our online pharmacy or see your GP to obtain a prescription on the NHS. Two common prescription treatments are Colpermin (peppermint oil) and Fybogel Mebeverine (ispaghula husk and mebeverine).

As well as prescription-strength treatments, you can also order over the counter treatments for IBS. These often contain the same ingredients as prescription medication but may contain a lower strength or quantity of medication. Examples include Buscopan IBS and Spasmonal.

Medication Summary


The recommended dose is one tablet three times a day.

You should not take more than three tablets per day.


It works on muscles in and around the gut to relieve symptoms of IBS.

Side effects

Mebeverine is a relatively well-tolerated drug, and side effects are uncommon. Howver, should you experience any signs of an allergic reaction to Mebervine, seek medical help immediately.

Colofac Reviews

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Content Reviewed: 23/03/21


  • What is colofac?

    It is a medication used in the treatment of irritable bowel syndrome (IBS). It contains the active ingredient mebeverine, which helps with muscle spasms in the gut.

  • What is the ingredient of Colofac?

    Colofac contains 135mg of the drug mebeverine.

  • How does Colofac work?

    It works by relaxing the muscles in the walls of the intestines. This helps to relieve spasms of the muscles in the gut, which can cause symptoms such as cramps, pain, and bloating.

  • How do I take Colofac ?

    The usual dose for Colofac is one tablet taken three times a day. This is different from the modified-release formulation of Colofac, which is taken as one tablet twice a day.

  • Is Colofac good for IBS?

    Colofac is very commonly prescribed for people who suffer from IBS. It can be effective at improving symptoms like abdominal pain, bloating, and cramps. However, Colofac is not effective for the other symptoms of IBS, such as diarrhoea and constipation.

  • When should I take Colofac?

    Ideally, you should take a dose around 20 minutes before eating. This can help to ease symptoms if they’re exacerbated after eating.

  • Can I buy Colofac online?

    Large pack sizes of Colofac, in the UK, are prescription-only medicines and must be prescribed by a doctor. The smaller pack size of 15 tablets is available to purchase over the counter at a pharmacy.


    You can request to order Colofac online from our online doctor service. Please note, you will need to complete a short online medical questionnaire as part of your order. This helps our doctors make sure it’s safe and suitable for you to take.


Treatment Comparison

ColperminColofac / MebeverineFybogel Mebevine
Active Ingredients0.2ml Peppermint OilMebeverineMebeverine / Ispaghula Husk.
MechanismUnclearAnti-spasmodic.Anti-spasmodic and bulk forming laxative
DosageONE capsule THREE times dailyNormal Release: Take ONE THREE times daily --- Slow Release - Take ONE tablet TWICE daily.Usually ONE sachet TWICE daily

Side Effects

Colofac Side Effects

Usually, it is a well-tolerated medication with few side effects. However, there is a risk of an allergic reaction when taking it. If you notice any symptoms of an allergic reaction such as difficulty breathing and swelling of the throat or mouth, seek medical attention immediately. 

Some people may also notice a skin rash or red, itchy skin after taking the tablets. Please contact a doctor or pharmacist for advice if you notice this side effect.

Further information can be found in the patient information leaflet.


Info Leaflet

You can read the patient information leaflet for colofac online, at



You can take up to 1 tablet 3 times a day. It may be more effective if taken around 20 minutes before a meal. The reason for this is that some people find their symptoms are worse after food.

Colofac MR tablets have a different dose. One tablet can be taken twice a day because the tablets stay in your system longer.

You should always take the medicine exactly as the doctor has told you to.

Order on Monday to Friday until 3:30pm guarantees next day delivery options


Prices From £10.95
As low as £0.11 / Tablet

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Medication Simple Online Pharmacy
300 £43.95
200 £31.95
100 £16.95


Medication Simple Online Pharmacy
200mg M/R Capsules (Twice Daily) x120 £17.95
200mg M/R Capsules (Twice Daily) x60 £10.95
135mg Tablets (Three Times Daily) x200 £21.95
135mg Tablets (Three Times Daily) x100 £12.95

Fybogel Mebeverine

Medication Simple Online Pharmacy


Medication Simple Online Pharmacy
135mg-tablets-three-times-daily x100 £9.95
135mg-tablets-three-times-daily x200 £18.95