• Colofac


Medication features

  • Standard release or modified release available
  • IBS Treatment
  • Better Value Generic Mebeverine Available


Order Colofac For IBS Online

You can request to buy Colofac IBS tablets online, from our UK registered online pharmacy and doctor service. After completing your assessment and checking out, your order will be passed to our UK registered doctors for review. If approved, our pharmacy team will dispense and dispatch your medication to your chosen address.

What is Colofac?

Colofac is a medication used in the treatment of irritable bowel syndrome (IBS). It contains the active ingredient mebeverine hydrochloride, an antispasmodic. It works by relaxing the muscles in and around the gut. 

This helps to relieve the symptoms associated with irritable bowel syndrome. It is a well-tolerated medication that is used extensively in the treatment of patients with IBS. IBS symptoms can include stomach pain and spasms, bloating, flatulence, diarrhoea and abnormal stools.

It is available in the UK as both normal release Colofac tablets or modified-release capsules (Colofac MR).

How does Colofac work?

IBS can cause muscle spasms in the intestines and can lead to symptoms like abdominal pain and cramps. The active ingredient in Colofac tablets, mebeverine, relaxes the muscles in the intestines to relieve spasms and cramps.

What is Colofac used for?

Colofac is predominantly used for irritable bowel syndrome however it can be prescribed for conditions such as chronic irritable colon, constipation related to spasms, mucous colitis and colon spasms.

Colofac Dosing

When using the instant release tablets, you can take up to ONE tablet THREE times a day. It is more effective if taken around 20 minutes before a meal. This is because most people find their symptoms are worse after food.

Colofac MR capsules have a different dose as the dose is released slowly over time. Take ONE capsule twice a day. As the capsule is released slowly throughout the day, it may be taken with less regard to food however taking your dose before breakfast and dinner may be beneficial.

You should always take the medicine exactly as the doctor has told you to. If you are unsure of the dose you have been prescribed, consult your doctor.

Colofac Summary


Take up to ONE tablet THREE times a day before a meal for tablets.


Take ONE capsule TWICE daily.

Type of medicine

Antispasmodic for IBS


Relaxes muscles in and around the gut to relieve symptoms of IBS.


135mg or 200mg MR Tablets

Active Ingredient



From £10.95

Side Effects

Can include rashes and skin itching

Colofac Prices

200mg Modified Release Capsules x 60


200mg Modified Release Capsules x 120


135mg Tablets x 100


135mg Tablets x 200


Colofac Alternatives

There are other treatment options available if this medicine is not right for you. You can request to order these from our online pharmacy or see your GP to obtain a prescription on the NHS. Two common prescription treatments are Colpermin (peppermint oil) and Fybogel Mebeverine (Ispaghula husk and mebeverine).

As well as prescription-strength treatments, you can also order over the counter treatments for IBS. These often contain the same ingredients as prescription medication but may contain a lower strength or quantity of medication. Examples include Buscopan IBS and Spasmonal.

Colofac Side Effects

Colofac is generally a well-tolerated medication with few unwanted side effects. However, there is a risk of an allergic reaction when taking it. If you notice any symptoms of an allergic reaction such as difficulty breathing and swelling of the throat or mouth, seek medical attention immediately. 

Some people may also notice a skin rash or red, itchy skin after taking the tablets. Please contact a doctor or pharmacist for advice if you notice this side effect.


Hywel McGlinchy, Clinical Pharmacist


Hywel McGlinchy

RoleClinical Pharmacist
Qual.Masters of Pharmacy
AboutHywel started with Simple Online Pharmacy in 2020. He's responsible for helping review and author accurate site content. He works with our GPs to make sure all aspects of the medicines are covered.


Is Colofac good for IBS?

Colofac is very commonly prescribed for people who suffer from IBS. It can be effective at improving symptoms like abdominal pain, bloating, and cramps. However, Colofac is not effective for the other symptoms of IBS, such as diarrhoea and constipation.

When should I take Colofac?

Ideally, you should take a dose around 20 minutes before eating. This can help to ease symptoms if they’re exacerbated after eating.

Can I buy Colofac online?

Yes, although Colofac in higher quantities is a prescription medicine, you can request to order Colofac online from our online doctor service. Please note, you will need to complete a short online medical questionnaire as part of your order. This helps our doctors make sure it’s safe and suitable for you to take.

Is Colofac available over the counter?

In small quantities of 15 tablets, Colofac is available over the counter. The larger quantities of 60-200 are prescription only in the UK but can be accessed by completing an online assessment reviewed by UK doctors.

Does Colofac cause weight loss or weight gain?

No, weight loss or gain is not a listed side effect of Colofac. Weight gain or loss is more commonly associated with a change in eating patterns in patients due to the discomfort of IBS symptoms.

How long does Colofac take to work?

Regular Colofac tablets will generally take 30-60 minutes to absorb and work. Colofac modified release capsules may take slightly longer to work as the dose is not released all at once, but the effect will last for up to 12 hours.


Treatment Comparison

ColperminColofac / MebeverineFybogel Mebevine
Active Ingredients0.2ml Peppermint OilMebeverineMebeverine / Ispaghula Husk.
MechanismUnclearAnti-spasmodic.Anti-spasmodic and bulk forming laxative
DosageONE capsule THREE times dailyNormal Release: Take ONE THREE times daily --- Slow Release - Take ONE tablet TWICE daily.Usually ONE sachet TWICE daily


Info Leaflet

You can read the patient information leaflet for Colofac online. It is recommended to do so before using the medicine as it contains information about the safety of the medicine, dosing, and side effects.


Warnings and Precautions

Colofac tablets or capsules may not be suitable for those with allergies to any listed ingredient in the medicine. Those with liver or kidney issues or with worsening symptoms must consult a doctor about their current condition before using the medicine to ensure safe and appropriate to use.

Colofac may be taken with alcohol although alcohol may worsen the irritation to the gut from IBS in general. If you find alcohol worsens your condition, avoid it or drink responsibly.

There are no known interactions between Mebeverine and other medicines.

Colofac in Pregnancy

Colofac is not recommended in pregnancy as there is limited evidence for its safety in pregnant women. A doctor may decide to prescribe the treatment however an individual risk-benefit must be done beforehand by the doctor.

Order within for guaranteed next day delivery options

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Medication Simple Online Pharmacy
300 £43.95
200 £31.95
100 £16.95


Medication Simple Online Pharmacy
200mg M/R Capsules (Twice Daily) x120 £17.95
200mg M/R Capsules (Twice Daily) x60 £10.95
135mg Tablets (Three Times Daily) x200 £21.95
135mg Tablets (Three Times Daily) x100 £12.95

Fybogel Mebeverine

Medication Simple Online Pharmacy
Fybogel Mebeverine x 10 Sachets £6.75


Medication Simple Online Pharmacy
135mg tablets three times daily x100 £9.95
135mg tablets three times daily x200 £18.95
200mg MR capsules x60 £9.95
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