Authored: 11/06/2022

Lymecycline is an antibiotic used to combat moderate to severe acne. It works by attacking acne-causing bacteria and decreasing inflammation, thus preventing further breakouts and improving skin clarity.
You can buy Lymecycline (Tetralysal) antibiotic capsules for acne online, from our UK registered online pharmacy and doctor service. After completing a short assessment, your order will be passed to our UK registered doctors for review.
If your online consultation is approved, our pharmacy team will dispense and dispatch your medication to your chosen address. We use Royal Mail as a courier. Options include standard delivery or next day delivery.
Tetralysal is a brand name of the medicine called Lymecycline. It is a prescription-only antibiotic that is used in the treatment of bacterial infections and the skin condition acne. It is often used for periods of 2 to 3 months for the treatment of acne.
Lymecycline 408mg and Tetralysal 300mg are the same strength. Both are equivalent to 300mg of the active ingredient.
Tetralysal is an antibiotic which means it kills certain bacteria. It is not known exactly how it treats acne but there are some known mechanisms. We have outlined these below.
People with acne can have higher than usual numbers of bacteria on their skin and this can cause the inflammation and pus seen in acne. The main bacteria that seems to cause this is called Propionibacterium acnes (P. acnes). Tetralysal helps to stop the growth of P. acnes on the surface of the skin.
It also reduces the concentration of free fatty acids in the sebum of the skin. This may also help to improve acne because free fatty acids in sebum are believed to be a possible cause of inflammation.
In adults and children over 12 years old the dose of Tetralysal is one 300mg capsule daily, preferably in the morning with a glass of water. You should take it for the duration that our doctors prescribe. This often depends on how quickly your acne improves but it is generally taken for at least 8 weeks. Lymecycline capsules should be taken in the same way.
If you forget to take your dose, take it when you remember and continue as before unless it is time for the next dose. A double dose should not be taken to make up for a forgotten capsule.
There is always a risk of side effects when taking any medicine. Please read the patient information leaflet to be aware of the potential side effects. The most common side effects include:
If Tetralysal makes you feel nauseous try to take it with or after food. This may ease this side effect.
On rare occasions, it can have serious side effects. If you get any of the following symptoms stop it immediately and tell your doctor urgently:
Tetralysal may cause visual disturbances as a side effect. If this happens, contact your doctor to let them know. Tetralysal may make the skin more sensitive to the sun. During treatment with Tetralysal, it's recommended to avoid direct sunlight and the use of sunbeds.
Dose | Take ONE capsule in the morning with a glass of water |
Type of medicine | Antibiotic |
Mechanism | Reduces bacteria on the skin that causes inflammation and pus to occur (acne) |
Active Ingredient | 408mg Lymecycline |
Price | From £14.50 |
Side Effects | Can include stomach upset, nausea, headaches, diarrhoea |
Tetralysal is used to treat moderate acne that has not improved with gels or creams. If you have mild or moderate acne the first treatments to try are creams or gels that contain retinoids such as Differin, Epiduo or Duac. Oral antibiotics, like Tetralysal, are usually used if creams or gels have not improved your acne.
If these, or Tetralysal, do not improve your acne our other available options are:
Usually, benzoyl peroxide gel or a retinoid cream should be prescribed alongside Tetralysal.
Sometimes doctors may prescribe an oral contraceptive called Dianette. This acts as a contraceptive pill but also has anti-acne properties that help to treat moderate or severe acne.
All of our medication and condition content is written by UK qualified pharmacists and doctors.
Authored: 11/06/2022
Reviewed: 23/01/2025
Duac | Differin | Tetralysal | |
Ingredients | Clindamycin / Benzoyl Peroxide | Adapalene | Lymecycline |
Action | Dual action on bacteria; antibiotic and skin shedding | Helps unblock pores and reduce inflammation | Antibiotic kills bacteria |
Oral or Topical? | Topical | Topical | Oral |
Directions | Apply thin layer at night after washing. | Apply thin layer at night after washing. | Take ONE capsules DAILY (preferably in the morning) |
Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at medicines.org, or by contacting us.
When filling out our online form, make sure to list any medicines you currently take. Some medicines can interact with Tetralysal such as:
Some medicines can bind to the active ingredient of Tetralysal in the stomach and make it less effective. To avoid this you should leave a two-hour gap between taking Tetralysal and the following medicines:
When filling out our online form, make sure to mention any medical conditions that you have.
You should not take Tetralysal if you have ever had an allergic reaction to another tetracycline antibiotic (such as doxycycline).
It may not be suitable if you have certain conditions such as:
See the patient information leaflet for further information.
Tetralysal crosses into the placenta and may cause harm to a foetus. Tetralysal is also present in breast milk. For these reasons, Tetralysal should not be used in pregnant or breastfeeding women.