Trisequens

Order Trisequens HRT Tablets Online

You can request to order Trisequens online without a prescription, from our UK registered online doctor. You will need to complete an online medical questionnaire to request this medicine.

Our doctors will then review your questionnaire to ensure it is safe and suitable to prescribe. If approved, our doctors will pass a prescription to our registered online pharmacy. Our pharmacy team will then dispense and dispatch your medication to your delivery address.

What is Trisequens?

Trisequens is a Hormone Replacement Therapy (HRT). It is used to help alleviate symptoms associated with the menopause. It can also be used to prevent osteoporosis in women after the menopause.

Trisequens contains two different active ingredients:

• Oestradiol (2mg and 1mg), an oestrogen hormone
• Norethisterone, a progestogen hormone

Trisequens is a type of HRT called continuous sequential HRT or cyclical HRT. This means that the oestrogen is taken every day and the progestogen is taken for 10 days of a 28-day cycle. This generally causes withdrawal bleeds every 4 weeks, whereas another type of HRT called continuous combined HRT does not cause bleeds.

How does it work?

Natural oestrogen levels drop during the menopause. This drop can cause menopausal symptoms such as hot flushes, vaginal dryness, sex drive changes, sleep disturbances and mood changes.

Trisequens contains oestrogen which replaces the oestrogen lost during the menopause. By replacing the lost oestrogen, Trisequens alleviates menopausal symptoms.

Taking oestrogens can increase the risk of developing womb cancer. Trisequens contains a progestogen, called norethisterone, which protects against this increased risk. The progestogen in Trisequens is taken for 10 days for every 28 days cycle. Taking it for this duration is enough to mitigate the risk of womb cancer. 

Dose

Each pack of Trisequens contains 3 different colour tablets. One tablet is taken daily in the following order:

• Days 1 - 12: Take one blue tablet every day 
• Days 13 - 22: Take one white tablet every day
• Days 23 - 28: Take one red tablet every day

Once you finish the pack, start a new pack the next day.  

Alternatives

Other forms of HRT include:

• Vaginal rings
• Topical gels
• Skin patches
• Vaginal creams
• Vaginal pessaries

Our doctors are able to prescribe a number of HRT products on our website:

• Kliovance
• Elleste Duet
• Elleste Duet Conti
• Livial
• Premarin
• Provera
• Premique Low Dose
• Elleste Solo
• Evorel Conti patches
• Evorel Sequi patches

Various HRT products have suffered from product shortages in recent years. There can be small differences between products, making it hard to find a direct alternative when one becomes unavailable to stock. 

The closest treatment options to Trisequens are Femoston 2/10 and Elleste Duet 2mg.

What is Trisequens used for?

Trisequens is a Hormone Replacement Therapy (HRT). It contains an oestrogen and progestogen. It is used to help alleviate symptoms associated with the menopause. It can also be used to prevent osteoporosis in women after the menopause.

How do I stop taking Trisequens?

If you want to stop HRT you should discuss stopping with your doctor. Menopausal symptoms can return after stopping HRT. The National Institute of Clinical Excellence (NICE) suggests patients can try to stop HRT at regular intervals and test whether their symptoms return. This should be done with the advice of a doctor. 

What does hormone replacement do?

Hormone Replacement Therapy (HRT) is used to treat menopausal symptoms. HRT replaces hormones that are lost during the menopause like oestrogen and progesterone. Reduced levels of these hormones are associated with menopausal symptoms. By replacing these hormones, HRT helps to improve symptoms.

How do you take Trisequens?

Each pack of Trisequens contains 3 different colour tablets. One tablet is taken daily in the following order:

• Days 1 - 12: Take one blue tablet every day 
• Days 13 - 22: Take one white tablet every day
• Days 23 - 28: Take one red tablet every day

Once you finish the pack, start a new pack the next day.

What are the benefits of taking HRT tablets?

HRT tablets can improve menopausal symptoms such as hot flushes, changes to libido, sleep disturbances, vaginal dryness and mood changes. By helping these symptoms, HRT can greatly increase the quality of life of some patients.

Can I request Trisequens online?

Trisequens can be prescribed online. Before prescribing HRT, UK registered doctors on our website need to assess each patient. 

You will need to complete a medical questionnaire which is then assessed by our doctors to make sure it is safe and suitable to prescribe. If approved, a prescription will be issued and passed to our pharmacy team who will then dispense and dispatch the medicine to your delivery address.

There is always a risk of side effects when taking any medicine. 

Common side effects of Trisequens include:

• Breast pain or tenderness
• Irregular menstrual cycles or excessive bleeding during period
• Weight gain
• Vaginal inflammation
• Fungal vaginal infection
• Leg cramps
• Nausea
• Weight gain
• Abdominal pain or discomfort

The patient information leaflet contains a full list of possible side effects.

Women should be aware of the potential risks of HRT before starting therapy. Women taking HRT report the following diseases more often than women who do not take HRT:

• Stroke
• Heart disease
• Ovarian cancer
• Endometrial cancer (the progestogen in Trisequens helps protect against this risk)
• Breast cancer
• Blood clots (venous thromboembolism)

The risk of blood clots in HRT users is up to 3x higher than in non-users. The risk is highest during the first year of treatment.

The risk of having a stroke is about 1.5 times higher in HRT users than in non-users.

The increased risk of breast cancer means that, out of 1000 women using HRT, 4-6 extra women in a 5 year period will be diagnosed with breast cancer compared to non-users of HRT.
HRT users should attend regular checkups with their doctor to monitor treatment efficacy and side effects. The NHS website contains information on the symptoms of breast cancer, endometrial cancer, blood clots and stroke as well as information on the risks of HRT.

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at medicines.org, or by contacting us.

• Trisequens Calendar Pack information leaflet

Other conditions and Trisequens

It is important to mention all medical conditions you have when completing the online medical questionnaire.  

Trisequens must not be taken:

• If you currently have or have a history of liver disease
• If you currently have or have a history of any oestrogen-dependant cancer (e.g womb cancer)
• If you have any unexplained vaginal bleeding
• If you have a blood clotting disorder
• If you currently have or have a history of blood clots
• If you are allergic to any of the ingredients in Trisequens
• If you currently have or have a history of heart attack, stroke or angina
• If you currently have or have a history of breast cancer
• If you have endometrial hyperplasia

Interactions with other medicines

It is important to mention every medicine you currently, or have recently, taken when completing the online medical questionnaire. Some medicines can interact with Trisequens such as:

• Medicines for Hepatitis C
• Medicines for tuberculosis
• Anti-epileptic medicines
• Anti-HIV medicines
• St John’s Wort - a herbal medicine

For further information read the patient information leaflet or speak to your doctor or pharmacist.