• Premarin
  • Premarin


Medication features

  • Contains of a combination of hormones
  • Helps control the body's natural oestrogen
  • Comes in 300mcg, 625mcg & 1.25mg


Buy Premarin HRT Tablets Online UK

After completing a short assessment on our website, it will be passed to our UK registered doctors for review. If this treatment is approved by our doctors, our pharmacy team will dispense your medication and dispatch it to your chosen address.

What is Premarin?

Premarin is a Hormone Replacement Therapy (HRT). It is used to treat the symptoms that occur after menopause. Premarin can also be used to prevent osteoporosis in postmenopausal women. 

Premarin is an oestrogen-only HRT. This is different to combined HRT or cyclical HRT which contain both oestrogen and progestogen.

Premarin contains conjugated oestrogens (conjugated estrogens) in three strengths: 0.3 mg, 0.625 mg, and 1.25 mg tablets.

How does it work?

During menopause the natural oestrogen levels in the body decline. This decline can cause menopausal symptoms which can begin before periods stop and can last around 4 years or longer. Examples of menopausal symptoms are hot flushes (or hot flashes), vaginal dryness, night sweats, reduced sex drive and poor memory or concentration.

Premarin works as a menopausal hormone therapy by replacing the oestrogen lost during menopause. This helps to relieve the symptoms associated with menopause.

High oestrogen levels in the body can increase the risk of womb cancer. Due to this, only women who have had their womb removed should take Premarin. If a woman who still has their womb takes Premarin, they must take a progestogen product alongside it to protect against the risk of womb cancer. Taking Progestins may increase the risks of experiencing side effects 


Do not change treatments without consulting your doctor.

Other types of HRT include:

  • Skin patches/gels
  • Vaginal rings
  • Vaginal creams
  • Vaginal pessaries

Our doctors are able to prescribe a number of HRT treatments:

Depending on the dose of Premarin taken, the following may be alternatives that have a similar effect.

Lower dose:

  • Elleste Solo 1mg tablets
  • Zumenon 1mg tablets
  • Progynova 1mg tablets

Higher dose:

  • Elleste Solo 2mg tablets
  • Zumenon 2mg tablets
  • Progynova 2mg tablets

Premarin Summary


Take ONE tablet at the same time each day. *Dose can vary


Raises oestrogen levels

Active Ingredient

Conjugated oestrogens


from £18.99

Side Effects

Can include cramping, breakthrough bleeding, breast tenderness, mood changes

Premarin Prices

0.3mg x 84


0.625mg x 84


1.25mg x 84



What does Premarin do to your body?

Premarin replaces the oestrogen that is lost during menopause. By doing this it helps to relieve symptoms of menopause.

Does Premarin cause weight gain?

Research has shown that women can gain weight during menopause. HRT may also cause weight gain and the manufacturers of Premarin note that weight increase or weight decrease are common side effects of the medicine. 

How long does Premarin take to work?

The full effects of HRT can take up to three months to show but some women may notice benefits within a few weeks of starting therapy.

What happens when you stop taking Premarin?

Menopausal symptoms can return after stopping HRT. The National Institute of Clinical Excellence (NICE) suggests patients can try to stop HRT at regular intervals and test whether their symptoms return. This should be done with the advice of a doctor.

Can HRT prevent heart attacks?

No, there is no evidence that HRT will prevent heart disease or heart attacks.

Can Premarin be prescribed online?

Premarin can be prescribed online. Before prescribing HRT, UK registered doctors on our website need to assess each patient. After completing an online consultation, if deemed suitable by our doctors, a prescription will be issued. Our pharmacy team can then dispatch your medication.

Side Effects

Premarin side effects

There is always a risk of side effects when taking any medicine. 

The following list contains some common side effects of taking Premarin:

  • Leg cramps
  • Breakthrough bleeding/spotting
  • Breast pain and tenderness
  • Breast enlargement
  • Weight gain or loss
  • Hair growth changes (loss or increase)
  • Mood changes including depression, anxiety and irritability

Some breakthrough bleeding or spotting can happen during the first 3-6 months of treatment. Report any unusual vaginal bleeding or other symptoms to your doctor.

The patient information leaflet contains a full description of potential side effects.

Patients should be aware of the risks associated with HRT prior to treatment. Users of HRT are at a higher risk of suffering from the following diseases:

  • Endometrial cancer
  • Breast cancer 
  • Heart disease
  • Stroke
  • Blood clots (venous thromboembolism)
  • Ovarian cancer

Taking oestrogen-only HRT (like Premarin) increases the risk of womb cancer in women who have not had their womb removed. In these patients, taking progestogen for at least 12 days every 28 days protects against this increased risk. In some cases, oestrogen-only HRT can be taken without progestogen in women who have had their womb surgically removed.

Scientific research suggests that the risk of breast cancer is higher in HRT users. This increased risk depends on the duration of treatment. The increased risk returns to normal within around 5 years of stopping treatment.

Users of HRT have a 1.3 - 3 times higher risk of developing blood clots than non-users of HRT. The risk appears to be highest during the first year of treatment.

The risk of having a stroke is about 1.5 times higher in HRT users than in non-users. The number of extra cases of stroke due to HRT use will increase with age. Other factors like high blood pressure and smoking can increase the risk of stroke. A recent analysis of risk in women aged 50 to 59 years suggests no increased risk for women taking 0.625 mg Premarin tablets.

Consult the patient information leaflet for further information on the risks associated with taking Premarin. Women taking HRT should be regularly checked by their doctor to monitor treatment and side effects. The NHS website contains information on the symptoms of blood clots, breast cancer, endometrial cancer and stroke as well as information on the risks of HRT.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet.


Premarin Dose

The aim of HRT treatment is to use the lowest effective dose for the shortest duration of time to minimise side effects. For this reason, treatment is normally started with Premarin 0.3mg tablets. This begins treatment at the lowest dose but is reviewed regularly and can be increased if deemed necessary.

The usual dose is one tablet a day, at the same time every day. Your doctor may prescribe a different dose. 

If you miss a tablet take it as soon as you remember and then continue taking Premarin as normal. A double dose should not be taken.


Other conditions and Premarin

It is important to mention any medical conditions you have during the online assessment. Premarin must not be taken if you:

  • Are currently pregnant or breastfeeding
  • Have unusual vaginal bleeding
  • Are allergic to any of the ingredients in Premarin
  • Have endometrial hyperplasia (a thickening of the womb lining)
  • Have or have ever had liver disease
  • Have any blood clotting disorders
  • Have or have ever had a blood clot
  • Have had recent angina (chest pain), stroke or heart attack
  • Have or have ever had breast cancer
  • Have or have ever had cancer sensitive to oestrogens (such as cancer of the uterus)

If you develop any of these during treatment you must stop taking Premarin and discuss treatment with your doctor.

If starting Premarin due to premature menopause due to ovarian failure or surgery, you must discuss the risks of HRT with a healthcare professional as your risks may be different.

Interactions with other medicines

It is important to mention any medicines you currently take when filling out the online assessment. Premarin can interact with the following medicines:

  • Anticonvulsants such as phenytoin or carbamazepine
  • Medicines to treat tuberculosis
  • Medicines to treat HIV
  • Certain antibiotics and antifungal medicines
  • The herbal medicine St John’s Wort
  • Metyrapone
  • Cimetidine
  • Dexamethasone

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