Colchicine 500mcg Tablets
  • Colchicine 500mcg Tablets

Colchicine 500mcg Tablets

Medication features

Colchicine is a medication used for the treatment and prevention of gout attacks. It works by reducing inflammation and alleviating pain associated with gout flares.

  • Treatment for Gout
  • Helps to reduce inflammation in the affected joint
  • Should only be used as a short course treatment


Order Colchicine 500mcg for Gout Online

You can buy Colchicine tablets online from our UK registered online pharmacy and doctor service. This is a prescription-only medicine which means you need to complete an online consultation to be reviewed by our doctors. 

If your request is approved, a prescription is sent to our pharmacy team who will dispense and dispatch the medicine to your chosen address.

What is Colchicine?

Colchicine is a prescription-only medicine that is used to treat attacks of gout. It's important to stick to your prescribed Colchicine dose. Taking even a little bit more can be very serious. The usual dose is one tablet taken, 2 to 4 times a day. The course of treatment should end when symptoms are relieved or when a total of 12 Colchicine Tablets have been taken. You should not take more than 12 Colchicine Tablets as a course of treatment.

The active ingredient is Colchicine 500mcg (500 micrograms).

How does it work?

Gout is caused by high levels of uric acid in the blood, which can lead to uric acid crystals forming in your joints. These crystals can cause pain and inflammation when they form in your joints. Colchicine tablets works by reducing the inflammation caused by these crystals, which also helps to reduce pain.

Colchicine Dosage

You should always take this medicine exactly as your doctor has told you to. For acute attacks of gout, the dose is usually one tablet taken 2 - 4 times a day. The course of treatment should end when symptoms are relieved or when a total of 12 colchicine tablets have been taken. You should not take more than 12 colchicine tablets as a course of treatment. A course of treatment should not be repeated for at least 3 days. 

See the patient information leaflet for further information. If you notice any side effects like diarrhoea, nausea or vomiting, or stomach pain then you should stop taking the tablets immediately and call 999 or go to A&E. 

If you forget to take a dose, take another as soon as you remember. If it’s almost time for your next dose, skip the missed dose. You should not drink grapefruit juice whilst you are taking colchicine tablets.

Side Effects

Like all medicines, colchicine can cause adverse effects, although not everyone gets them. However, even mild side effects of colchicine can be serious. If you notice any of the following side effects when taking this medicine, you should call 999 or immediately go to A&E: 

  • Nausea or vomiting
  • Stomach pain
  • Diarrhoea
  • Have a high temperature, swollen mouth, sore throat, bleeding that does not stop, unusual bruising or skin problems – these can be signs of a serious problem with your blood

See the patient information leaflet for a complete list of possible side effects.

Colchicine alternatives

Several other medicines can be used to treat an acute flare up of gout. Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen are often used to treat a gout attack. Sometimes patients are prescribed a short course of corticosteroid tablets like prednisolone.

For people who experience frequent attacks of gout, medicines can be taken to help prevent future attacks. Allopurinol is commonly prescribed to be taken daily to prevent gout, or sometimes another medicine called febuxostat is prescribed.

Colchicine summary


Colchicine 500 micrograms tablets

How it works

Reduces inflammation caused by gout in joints



How long until it works

Starts to work within 2 hours


How fast does colchicine work?

It starts to work to treat inflammation within 2 hours. But you may not notice an improvement in your pain and inflammation for a day or two. If you find your gout symptoms do not improve after 2 days, contact your doctor or pharmacist for advice.

Is colchicine a painkiller?

Colchicine isn’t a painkiller but it is effective at improving pain for people suffering from an attack of gout. This is because it works to reduce the inflammation in the joint that causes gout pain. 

What is colchicine used for?

Colchicine is primarily used to treat acute gout flare-ups. It is sometimes used to prevent gout attacks when someone first starts taking allopurinol or febuxostat. It can also be prescribed for a condition called familial Mediterranean fever which is a rare inherited autoinflammatory disease.

Can you buy colchicine over the counter?

Colchicine, in the UK, is a prescription-only medicine and cannot be bought over the counter at pharmacies. However, you can request to buy Colchicine online at certain registered online pharmacies. Your order can be assessed by an online doctor to make sure it is safe for you to take.

Written by Qualified Experts

All of our medication and condition content is writted by UK qualified pharmacists and doctors.


Karim Nassar, Pharmacist

Authored By: Karim Nassar

GPhC Registration: 2071234

Date Authored: 12/03/2022


Hywel McGlinchy, Clinical Pharmacist

Reviewed By: Karim Nassar

GPhC Registration: 2064752

Last reviewed on: 12/03/2024




This medicine is not suitable for everyone to take. It should not be taken by anyone who is allergic to colchicine or any of the ingredients in the tablets. It should not be taken by women who are pregnant or breastfeeding. Women who can get pregnant should not take it unless they are taking effective contraception. 

People with medical conditions like blood disorders and liver or kidney problems should not take colchicine. See section 2 of the patient information leaflet for further information and a complete list of other conditions affected by this medicine.

Interactions with other medicines

Colchicine can interact with various medicines such as antifungal medicines and antibiotics. It should also not be taken with disulfiram and certain heart medicines like verapamil and diltiazem.

For a complete list of drug interactions, see the patient information leaflet. If you are unsure, ask your pharmacist or doctor for medical advice.

You should not drink grapefruit juice whilst you are taking colchicine tablets.

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Colchicine 500mcg Tablets

Medication Simple Online Pharmacy
500mcg x12 Tablets £17.50
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