Ovestin Cream
  • Ovestin Cream

Ovestin Cream

Medication features

  • Comes with a reuseable applicator
  • Fast Acting Relief 
  • HRT medication


Order Ovestin Cream Online

You can request to order Ovestin cream online in the UK from our registered online doctor and pharmacy service. This is a prescription-only medicine and must be prescribed by one of our UK registered doctors. Simply complete an online assessment as part of your order for our doctors to review.  

If your order is approved, a prescription is sent to our online pharmacy team. From here, your medicine will be dispensed and dispatched to your chosen delivery address.

What is Ovestin cream?

Ovestin cream contains the active ingredient estriol. It is a type of medicine called Hormone Replacement Therapy (HRT). It is used to relieve menopausal symptoms that affect the vagina such as irritation or dryness.

Other HRT medicines, like patches or tablets, are used to treat different menopause symptoms like night sweats and mood changes. You can visit our online HRT clinic for more information.

Ovestin 1mg cream contains 1mg of Estriol per 1g of cream.

How does Ovestin cream work?

The drop in oestrogen levels in the body that happens after the menopause can cause vaginal problems. 

After the menopause, the decline of oestrogen levels in the body can cause menopausal symptoms like vaginal dryness. The active ingredient in Ovestin cream, estriol, acts as a substitute for the lost oestrogen. By replacing the lost oestrogen, it can help to relieve symptoms like dryness, irritation, pain during sex, and recurrent infections.

How to apply Ovestin cream

Applying Ovestin may be more convenient just before bed. The pack contains a cream and a plastic applicator. The applicator is used to apply the cream in the vagina. The applicator has a ring marked on it, filling the applicator up to the ring with cream will provide the correct dose.

Screw the end of the applicator onto the tube of cream and squeeze the tube until the applicator is filled to the red mark. Unscrew the applicator from the tube and put the cap back on the tube. Lie down and put the end of the applicator deep into your vagina and slowly push the plunger all the way in. This releases the cream into your vagina. 

Remove the applicator and clean the applicator in hot and soapy water after every use. See the patient information leaflet for complete instructions with diagrams.

Ovestin cream alternatives

Other treatments can be used to alleviate vaginal dryness. Vagifem contains the oestrogen estradiol and it is a vaginal tablet inserted into the vagina using an applicator. Another product containing estradiol is Estring, which is a vaginal ring that is inserted into the vagina and replaced every 90 days.

Vaginal moisturisers like Replens MD and Sylk lubricant can be used to relieve vaginal dryness and irritation.


What is Ovestin cream used for?

Ovestin cream is used to treat vaginal dryness and irritation that can affect women during the menopause. This is also known as vaginal atrophy. Ovestin increases oestrogen levels in the vagina which helps to relieve vaginal symptoms. 

It can also be used before and after vaginal surgery to help wound healing.

How long can you use Ovestin for?

You should use Ovestin for as long as your doctor has prescribed it. Usually, you should have at least yearly reviews of this medicine to make sure it is still safe and suitable for you to use.

How long does it take for Ovestin cream to work?

It can take several days or weeks of using the cream before you notice an improvement in your symptoms. If you think there is no improvement in your symptoms after using the cream, speak to your doctor to discuss an alternative.

What are the side effects of oestrogen cream?

Oestrogen creams like Ovestin can cause side effects. Vaginal discharge, bleeding, or spotting can occur. It can also cause itching or irritation in or around the vagina at the start of treatment. See the patient information leaflet for a complete list of side effects. If you experience any side effects with an oestrogen cream, talk to your doctor for advice.

Can you buy Ovestin over the counter?

Ovestin cream, in the UK, is a prescription-only medicine and cannot be bought over the counter. However, you can request to buy Ovestin cream online in the UK from our UK registered online pharmacy and doctor service. 

If your order is approved, our online pharmacy team will dispense and dispatch the medicine to your address via Royal Mail.

Side Effects

Ovestin Side Effects

Ovestin can cause some vaginal side effects such as vaginal discharge, bleeding, or spotting. It can also cause itching or irritation in or around the vagina at the start of treatment. This usually improves after several weeks of use. Other possible side effects include swollen and tender breasts, headaches, and nausea.  

If you notice any side effects with Ovestin, stop using the cream and consult your doctor.

HRT medicines containing oestrogen can cause an increased risk of serious conditions such as stroke, ovarian cancer, and blood clots. The increased risk is likely less with treatments administered vaginally because they have less of an effect on the whole body. However, you should read the patient information leaflet to learn about these risks. If you have any questions, contact your doctor or pharmacist for medical advice.


Ovestin is not suitable for some women. Anyone with a history of breast cancer, or a cancer sensitive to oestrogens (e.g. endometrial cancer) should not use it. It is also not safe to prescribe for women with a blood clotting disorder or a history of blood clots. See section 2 of the patient information leaflet for a complete list of conditions and disease that Ovestin cream may be unsafe for.

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Prices From £20.99 / 1x 15g

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Medication Simple Online Pharmacy
10mcg x24 Tablets £39.99

Estring HRT Vaginal Ring

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7.5mg Vaginal Ring £69.99

Ovestin Cream

Medication Simple Online Pharmacy
15g x1x 15g £20.99
15g x2 x 15g £33.99