So easy
Ordering is quick and easy and medication arrives quickly. I’ve lost over ten stone with mounjaro from here and any issue has been easily and quickly dealt with. Would recommend to anyone.
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Read more hereWeight loss injections
Extra support when willpower alone isn’t enough. Prescription injections assessed by our clinicians to help regulate appetite and support steady progress.
Wegovy
Buy once-weekly Wegovy GLP-1 injection pens that help reduce appetite and supports sustainable weight loss.
- Up to 20.7% body weight loss in studies
- Once-weekly injection
- Well-established safety profile
Mounjaro
Mounjaro is a once-weekly injection pen that target two hormones (GLP-1 and GIP) for enhanced weight loss results.
- Up to 22.5% body weight loss in studies
- Once-weekly injection
- Dual hormone action (GLP-1 + GIP)
Weight loss pills
Support in a form that fits your routine. Oral prescription treatments assessed by our clinical team and used alongside diet and activity changes.
Wegovy pill
Daily oral semaglutide for weight loss, assessed through our clinician-led service.
Foundayo
Once Daily oral pills for weight loss, assessed through our clinician-led service.
Orlistat
Generic orlistat for adults with a BMI of 28+ that reduces fat absorption when taken with meals.
Xenical
Branded 120mg orlistat for BMI 30+, or 28+ with conditions, alongside a low-fat diet and exercise.
Alli
Licensed 60mg orlistat capsule for BMI 28+ that reduces fat absorption with diet and activity.
UK-registered pharmacy
Clinician-led prescribing
Speedy, discreet delivery
Mounjaro vs Wegovy at a glance
Both Wegovy and Mounjaro are once-weekly injections prescribed for weight loss. They're effective in different ways, and the right choice depends on how your body responds, not just the headline numbers.
Quick comparison
Mounjaro
Wegovy
How it works
Dual GIP and GLP-1 receptor agonist
GLP-1 receptor agonist
Active ingredient
Tirzepatide
Semaglutide
Head-to-head average weight change at 72 weeks*
22.5% reduction
20.7% reduction
Dosing
Once-weekly injection
Once-weekly injection
Common side effects
Mainly gastrointestinal
Mainly gastrointestinal
*Figures are from separate 72-week trials and are not a direct comparison. Mounjaro: SURMOUNT-1, tirzepatide 15mg (22.5%). Wegovy: STEP UP, semaglutide 7.2mg (20.7%). Both results use on-treatment efficacy analyses and involved adults without type 2 diabetes alongside lifestyle support. Individual results vary. Read SURMOUNT-5.
What to consider
The medicines work in different ways, and study averages cannot predict an individual result.
Your medical history, current medicines, experience of side effects, cost and availability can all affect the decision.
Neither option is suitable for everyone. A clinician will assess which treatments are safe and appropriate for you.
Weight loss treatment explained
Side effects, safety and what to expect
- Covers the concerns many people have when starting treatment
- Explained in clear, straightforward language
- A simple overview before exploring the details below
How to get started
Our simple process makes it easy to access the right treatment for you.
Complete a simple assessment
Answer questions about your health, lifestyle, and goals.
Your assessment is reviewed by a clinician
A UK-registered prescriber carefully reviews your assessment to ensure treatment is safe and suitable for you.
Receive discreet delivery
Your medication is dispensed by our registered pharmacy and delivered directly to your door in plain packaging.
Stay supported
Schedule reviews with our specialist teams to monitor your progress and provide support throughout your journey.
Why choose Simple Online Pharmacy
We provide clinician-led weight loss support with clear guidance at every step. Our team reviews each consultation individually to ensure your treatment is safe and suitable.
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patients have trusted us
4.7/5
Trustpilot rating
35K+
patient reviews
Simple Online Pharmacy is fully registered with the GPhC and uses UK-registered clinicians.
Real stories from our patients
When April began her journey with Simple Online Pharmacy, she didn’t just lose weight, she regained her confidence, her health and her ability to say “yes”!
After the birth of her son, she struggled with weight gain and postpartum anxiety, and it took a friend’s success to encourage her to try Simple Online Pharmacy.
"I wish I'd done it sooner. To be honest, I can't stop screaming from the rooftops... it's saved my life in more ways than one. My confidence, my mental health... everything got better. That's all I can say. I'm just a happier person."
April
52,000+ verified customer reviews
4.6 out of 5 stars from 52,000+ reviews4.6 out of 5Trustpilot
I've been struggling with being…
I've been struggling with being overweight all my life...I've been practicing and following different diets, but the results were different, but I wasn't happy, I was starving myself, etc.... now I look as I wanted, maybe I don't eat healthy, but there are so many temptations, but using mounjaro treatment, life has gained a sparkle, I feel great, I try size M no longer 2xxl...it speaks for itself....if you can afford it, try to judge for yourself....I came and tried and huuurarrrrra
In the last 12 months I have lost 6…
In the last 12 months I have lost 6 stones. The delivery is really quick and website is easy to navigate. Since starting my blood pressure has lowered and stayed steady also being disabled with degenerative disc disease it has helped with my mobility. Im now on 7.5mg mounjaro and losing steadily and only got 2 stone to go. I highly recommend this company
14 months in and 3 stone down!
I started my weight-loss journey 14 months ago. I found the site easy to manage and had no problems with Wegovy. I am disabled so find it hard to exercise also mixed with peri-menopause i just could not shift any weight. Now i am nearly 3 stone down, in a healthy BMI, my joints don’t ache anymore and my all round health is soo much better. I have so much more confidence and it’s been lovely getting into my old jeans again! I have also referred 3 friends and so have benefitted from the discounts.!
Simple in the name and simple in the…
Simple in the name and simple in the ease of ordering. 12 months+ of Medication ordering and it’s never failed to be simple. Efficient delivery process, always arriving on time and cooled even over the summer. Would not hesitate to recommend them to anyone interested it weight loss medication.
My 18-Month Journey with Wegovy: More Than Just Weight Loss
I’ve now been using Wegovy for around a year and a half, so I feel I have a much better understanding of what the journey actually involves. When I started, naturally, my main goal was to lose weight. I don’t think I fully appreciated at the time that staying on track in the long term would be just as important as losing the weight in the first place. For me, one of the biggest differences has been appetite control. Food simply takes up less space in my thoughts than it used to. I find it easier to manage portions and make everyday decisions about food without constantly feeling that I’m fighting against myself. It hasn’t all been straightforward, though. I’ve had to pay attention to how my body responds to different doses. At 1.7 mg, I felt that my appetite and weight were becoming harder to control again, so I moved to 2.4 mg. This has taught me that everyone’s experience is different and that treatment needs to be reviewed rather than treated as a one-size-fits-all solution. After 18 months, I would say the biggest lesson is that this isn’t something you can approach as a quick fix. You still need to be aware of your habits, your eating patterns and how your body feels. There are good periods and more challenging ones. If I could give one piece of advice to someone just starting, it would be not to judge the whole experience by the first few weeks or even the first few months. Give yourself time. Learn what works for your body, be realistic about maintenance and don’t expect everything to happen in a perfectly straight line. I’m still on this journey, but I feel much more informed about my body and what long-term weight management actually means. That’s probably the biggest change of all.
Super fast and efficient
Super fast and efficient. Really happy with the service so far
Simple Online Pharmacy
Simple Online Pharmacy changed my life for the better since starting GPL-1 medication over 12 months ago, I’ve lost over 5 stone in weight, my blood pressure and cholesterol levels are down and I’m no longer a diabetic, they are easy to order from and their delivery service is extremely quick.
Treatment on your terms
We believe you should be in control of your treatment, not locked into something that doesn't work for you.
No commitments
Order when you need to, not when we tell you to. You're always in control of your next order.
Simple reordering
When you're ready for your next dose, reordering takes seconds. Your details are saved, and our clinicians review every order to make sure it's still right for you.
Support if you want it
You can message our clinical team if side effects are hard to manage, your weight changes, or you’re unsure about your next dose. No pressure, no upselling.
What our expert says
For too long, people struggling with their weight have been told it's simply a matter of willpower. But the science tells a different story. Weight regulation is controlled by complex hormonal signals that vary from person to person.
Weight management is not solely about willpower. It is influenced by biological systems that regulate appetite and metabolism. Modern treatments work with these systems to support sustainable, healthier outcomes.
Superintendent Pharmacist
Our expert team
Our committed clinical team, consisting of expert doctors, pharmacists, dietitians, and health coaches, is dedicated to supporting you at every stage of your health journey. Join over 1,000,000 UK patients who trust Simple Online Pharmacy with their health.
Understanding side effects
The most common early side effects. For most people it improves within the first few weeks as the body adjusts.
Nausea
More than 1 in 10 people
"Will I feel sick all the time?"
Reality: The most common early side effect, particularly when starting or increasing your dose. For most people it settles within a few days to a couple of weeks as the body adjusts.
Diarrhoea & constipation
More than 1 in 10 people
"What if my body reacts badly?"
Reality: Both are very common early on. Weight loss injections slow digestion, which can disrupt normal bowel patterns. They're usually manageable and improve as your body settles.
Bloating & burping
Up to 1 in 10 people
"Will I feel uncomfortable all the time?"
Reality: Bloating, gas and burping can occur as your digestive system adjusts to the medication. They're more common early in treatment and tend to ease over time.
Fatigue
Up to 1 in 10 people
"Why do I feel so drained?"
Reality: Fatigue is a common side effect of weight loss injections. It's not fully understood, but is likely linked to lower calorie intake, blood sugar changes, or disrupted sleep. It usually improves as your body adapts.
UK clinicians
Gradual dosing
Ongoing support
Treatment adjustments
It's not willpower. It's biology.
Hormones regulate hungerGLP-1 and GIP are hormones that tell your brain when you're full. Some people produce less of these signals, making it harder to feel satisfied after eating.
Genetics influence weightResearch shows that 40-70% of weight variation between people is due to genetic factors. Your genes affect metabolism, fat storage, and appetite regulation.
Treatments that work with your bodyModern weight loss medications mimic your body's natural hormones, helping restore the signals that regulate appetite and blood sugar.
Choosing the right weight loss treatment
Understanding your options helps you make an informed decision with your clinician.
Injectable vs oral treatments: what's the difference?
Injectable weight loss treatments like Mounjaro and Wegovy work by mimicking hormones that regulate appetite and blood sugar. In clinical trials, they've shown higher average weight loss than tablet options, often in the range of 15-22% of body weight (results vary).
Oral treatments can be a good option for people who prefer tablets or who aren't suitable for injections. They tend to produce more modest weight loss, but can still be effective as part of a broader plan.
The right choice isn't just about results. Some people find a once-weekly injection fits easily into their routine, while others prefer a daily tablet. Your clinician will help you weigh up what's most suitable for your health and lifestyle.
How do clinicians decide which treatment is suitable?
Clinicians review your BMI, medical history, current medications, and any underlying health conditions before recommending a treatment.
For injectable GLP-1 treatments, this usually means a BMI of 30 or above, or a BMI of 27 or above with a weight-related health condition, such as type 2 diabetes or high blood pressure.
This isn't about gatekeeping. It's about safety. Some conditions, like a history of pancreatitis or medullary thyroid cancer, mean certain treatments aren't suitable. A proper assessment helps protect you and ensures the treatment has the best chance of working.
Why does dose titration matter?
Most weight loss injections start at a low dose and increase gradually over several weeks. This process, known as dose titration, helps your body adjust and reduces the chance of side effects such as nausea.
Increasing the dose too quickly doesn't speed up weight loss. It usually just makes side effects harder to manage. People who follow the recommended titration schedule tend to stay on treatment longer and see better results over time.
When does switching treatments make sense?
Sometimes a treatment that worked well at first becomes less effective, or side effects don't settle as expected. In these cases, switching to something different (for example from Wegovy to Mounjaro, or to an oral option) can be helpful.
Our clinicians monitor how you're responding and can suggest changes if your current plan isn't delivering. Adjusting treatment is a normal part of long-term weight management, and there's no one-size-fits-all approach.
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Weight loss FAQs
Common questions about weight loss treatments and our service.
Which weight loss treatment is best for me?
The right treatment depends on your health, BMI, medical history, and personal preferences. Our clinicians will review your assessment to recommend the most suitable option.
Do I need a prescription for weight loss medication?
Yes, all effective weight loss medications in the UK require a prescription. Our clinicians will assess your suitability and issue a prescription if appropriate.
How much weight can I expect to lose?
Results vary between individuals and treatments. Injectable treatments like Mounjaro and Wegovy typically show higher weight loss percentages than oral medications. Your clinician can discuss realistic expectations.
Are weight loss injections safe?
GLP-1 injections like Mounjaro and Wegovy have been through extensive clinical trials and are approved for use in the UK. Like all medications, they have potential side effects which your clinician will discuss with you.
How long do I need to take weight loss medication?
Treatment duration varies. Some people use medication for a set period to reach their goal weight, while others may benefit from longer-term use. Your clinician will review your progress regularly.
Can I get weight loss treatment on the NHS?
Some weight loss treatments are available through NHS specialist services, but eligibility criteria are strict. Private services like ours offer an alternative with faster access.