Flexiseq Active Gel 100g
  • Flexiseq Active Gel 100g
  • Flexiseq Active Gel 100g
  • Flexiseq Active Gel 100g

Flexiseq for Joint Wear and Tear

From £11.25

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Buy Flexiseq for Joint Wear and Tear Online

What is Flexiseq Joint Wear & Tear?

Flexiseq Active is a drug-free solution to provide care and pain relief for joints that are under constant strain. It is specially designed for people who do sports or have an active and sportive lifestyle, who can sometimes have additional pressures put on their joints.

Whether it be football, basketball, tennis, hiking or jogging, Flexiseq Active can provide joint lubrication to help prevent the friction that can lead to joint problems. Flexiseq Active is a long-term solution for sportsmen and women and other active people who wish to protect against friction, wear and tear that might appear in their joints during periods of physical exertion. 

For more information on Flexiseq Active Gel please see our FAQ section!

How does Flexiseq Joint Wear & Tear work?

Flexiseq Active is a topical gel which contains sequessome vesicles.  Sequessome helps to target internal joint pain and help bring pain relief through this gel formula.   Sequessome vesicles pass through the skin as the Flexiseq gel evaporates which helps to ease the pain and stiffness in the areas affected.  

Flexiseq Active contains less sequessome vesicles than original Flexiseq or the Max Strength variety which makes it more suitable for daily use on joint pain

How quickly does Flexiseq take to work?

When applied twice-daily, users will begin to notice relief from stiffness and pain in the joints within 48 hours. It can take around 2 weeks for the sequessome ingredient to be absorbed fully by the joints and results to be noticed.  

It is recommended that the product is used longer term for Flexiseq Active to be fully effective.  Speak to your doctor or pharmacist for advice on directions and choosing the correct course of treatment if you are suffering from osteoarthritis.

How to use Flexiseq Gel?

Flexiseq should be applied twice a day to the affected area and is recommended for external use only.  Apply directly to the surrounding skin to help relieve pain and stiffness in the affected joints.  This should help bring about a noticeable improvement in joint pain in as little as two days, with noticeable improvement taking two weeks.

The following steps should be applied when using Flexiseq;

1..  Apply twice a day, once in the morning and once at night.

2.  Use hands to apply gel covering the front and back of the joint evenly and with enough gel to cover the affected area.Avoid rubbing the formula in. 

3.  Allow Flexiseq gel to dry for the recommended 10 minutes.  If the product dries earlier than this, apply a small amount more. Then cover

4.  Wash hands thoroughly after applying, unless hand joints are being treated.

*Discard any unused gel after 3 months.

Why use Flexiseq?

Flexiseq is clinically proven to help reduce pain and restore joint mobility. The gel has been shown to be as effective as a leading oral prescription-only medicine in trials with hundreds of patients.

It does not contain any pharmaceutically active ingredients and so is safe to take with your current medication. Flexiseq works by helping lubricate the joints by replicating the properties of synovial fluid. The sequessome vesicles are both flexible and compressible and this increases their ability to effectively lubricate the joint.

Once applied to the skin, Flexiseq gel begins to dry, which triggers the activity of the Sequessome vesicles through the skin. This gel is a great alternative to the standard treatments of joint pain and can be used in conjunction with existing treatments.

Can I use Flexiseq when pregnant or breastfeeding?

Flexiseq gel should not be used by women who are pregnant or breastfeeding.  Consult your doctor or healthcare professional to discuss any alternative treatments 

Alternatives to Flexiseq Active Joint Wear & Tear Gel

Flexiseq Active Joint Wear & Tear is a made with a drug free formula that can be used longer time by people that suffer from osteoarthritis.  Those who are unable to use pain relievers such as NSAID (Non Steroidal anti-inflammatories) or paracetamol may find this drug free treatment particularly helpful.    

We understand joining paint and osteoarthritis can be very difficult and painful to manage, alternative pain relief available over the counter include alternatives such as,

Oral pain relief- paracetamol or ibuprofen
Topical creams and gels - Movelat Cream or Ibuprofen Gel

To view our full range of pain relief products, visit The Simple Online Pharmacy pain relief section today.



  • What is Flexiseq?

    Flexiseq Gel is a topical application to help in the relief of joint pain often associated with arthritic conditions.

  • What is the ingredient of Flexiseq?

    Flexiseq is a drug-free treatment, which uses Sequessome Technology to help lubricate the painful joint.

  • How does Flexiseq work?

    Flexiseq works by inserting Sequessome vesicles into the joint. These vesicles seek out a watery environment, and penetrate the skin once dried, until they reach the joint.
    Here they enter into the synovial fluid of the joint, helping lubrication. The accumulation of the vesicle on the cartilage surfaces help relieve pain with this lubricating layer.

  • How do I use Flexiseq?

    Flexiseq should be applied twice daily. Depending on the size of the joint you will require a different amount. You may need to apply up to 3g for the hip, 2g for the knee, and 1g for the hand.

  • How effective is Flexiseq?

    Flexiseq has been shown in clinical studies to achieve a reduction in pain by upto 50%, and improve movement by 40%

  • What are the side effects of Flexiseq?

    The most common side effects of Flexiseq are slight skin reactions, sometimes cause by sensitivity to some of the ingredients in the gel.

  • How soon does Flexiseq work?

    You will usually notice the difference after two days of use.

Side Effects

  • There have been no serious side effects reported, relating to Flexiseq.
  • Flexiseq can cause minor skin irritations, although not everybody gets them.
  • Side effects affecting the skin and subcutaneous tissue (the soft tissue beneath the skin) could occur
    after approximately two weeks of treatment, but should disappear within a further few weeks if you
    continue to use the product. In case of continuing side effects, you may first reduce the dose (e.g.
    from twice daily to once daily). If this does not improve the condition, you may discontinue treatment
    with the product until the event resolves, which could be within a few days. You may then be able to
    restart administration of the product after improvement of the skin condition, if there is no evidence
    of allergic reactions resulting from skin contact.
  • In the event of serious side effects, or if you notice any side effects not listed in this leaflet,
    please tell your doctor or pharmacist.
  • There are no known interactions with other medicines


Info Leaflet

Before using this treatment, it is important to read the Patient information leaflet.  You can find information leaflets for your medicines by typing them in to the search bar or by contacting us, 

Flexiseq PIL


Flexiseq should be applied twice daily to the affected joint, usually in the morning and the evening. Use enough gel to evenly cover the soft tissue around the joint.

For the knee: a twice-daily dose of 2.2 g corresponding to approximately 7 cm line of gel as squeezed from the tube is recommended. The gel should not be applied to the patella (knee cap) and should include the area at the back of the knee. 
The gel must be allowed to dry before covering; drying should take no longer than 10 minutes if the product is applied to clean, dry skin. If drying takes longer than this, ensure that the skin is dry (for example if applying after a bath or shower) and try using a little less gel. 
Alternatively, a hair dryer (on a low/cool setting) can be used to speed up the drying time. If the drying time is considerably less than 10 minutes then a little more gel can be used next time. Please wash your hands after applying the gel.

For the hip: Locate the edge of your pelvis (or hip bone) at your side and apply the gel approximately two inches below where you can no longer feel bone but soft tissue. Do not spread towards the buttocks but instead towards your centre line. 
It is difficult to give precise dosing amounts for the hip as the size of this joint can vary widely from patient to patient. 
If you consider yourself to be of average weight, use approximately 3 g (approximately 10 cm line of gel as squeezed from the tube) to cover an area of approximately the size of your hand. 
If you believe you are above average size, you may need to apply a little more. You will know if you have applied the correct amount as it should take around 10 minutes to dry. 
For the first few applications, the amount applied may need to be increased or decreased to achieve a 10 minute drying time.

For the shoulder: It is difficult to give precise dosing amounts for the shoulder as the size of this joint and location of the pain varies from patient to patient. 
If you consider yourself to be of average weight, use approximately 2.2 g corresponding to approximately 7 cm line of gel as squeezed from the tube to cover the area corresponding to the location of your pain.
If you believe you are above average size, you may need to apply a little more. You will know if you have applied the correct amount as it should take around 10 minutes to dry (although may remain tacky after this time).


The following warnings apply to Flexiseq

  • Keep out of children's reach
  • Avoid contact or use on eyes.
  • Do not use it if you are allergic to any of the ingredients in this product.
  • Avoid using on broken or irritated skin.


Aqua, Phosphatidylcholine, Alcohol, Glycerin, Carbomer, Polysorbate 80, Disodium phosphate, Sodium hydroxide, Benzyl alcohol, Methylparaben, Ethylparaben, Linalool, Disodium EDTA, Sodium phosphate, Sodium metabisulfite, BHT. 

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