Recent years have seen a huge surge in injectable weight loss drugs. These drugs support weight loss by slowing down the emptying of your stomach, which can help to reduce appetite.
Eli Lilly’s Mounjaro builds on this, and is the first of these drugs to work on two different pathways to provide significant weight loss effects. Here we weigh up the cost, side effects and weight loss results of each to help you compare a Ozempic vs Mounjaro review for weight loss.
What is Mounjaro?
Mounjaro KwikPen is an injectable weight management medication containing the active ingredient tirzepatide. It is primarily used to help patients with a BMI of over 30 to lose weight. It works on two different pathways to help you lose weight: glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptors.
Traditional GLP-1 medications help slow down the emptying of your stomach, helping you feel fuller for longer. Mounjaro works on both GLP-1 and GIP receptors, which stimulate your brain to produce the feeling of fullness. In this way, Mounjaro helps weight loss by acting on both the brain and the digestive system to reduce appetite.
What is Ozempic?
Ozempic is similar to Mounjaro. Created by Novo Nordisk, it is also an injectable medication that was originally designed to help adults manage type 2 diabetes with blood sugar control.
Ozempic contains semaglutide, the same active ingredient as the weight loss drug Wegovy. Semaglutide is a GLP-1 agonist medication, meaning it replicates the action of naturally-occurring hormones to reduce your appetite.
However, Ozempic has not been officially approved for weight loss. Wegovy contains a higher dose of semaglutide, which is more suitable for use in weight loss. Read more about what Ozempic is in our deep dive.
Comparison
Both Ozempic and Mounjaro are once-a-week injections, and both come in pre-filled injection pens.
However, Ozempic has not been officially approved for weight loss. Instead, the same drug (semaglutide) has been rebranded as Wegovy. Wegovy contains a higher dose of semaglutide, which is more suited to weight loss.
You can learn how to use Ozempic in more detail by reading our guide on how to use Ozempic for weight loss.
Mounjaro vs Ozempic for Weight Loss
Both Mounjaro and Ozempic have been found to be effective weight loss treatments. Ozempic contains semaglutide at doses of 0.25 mg to 1 mg. Studies have found that people taking Ozempic at these doses do experience weight loss, however, it is usually recommended that you take semaglutide at higher doses for weight loss.
High-dose semaglutide, specifically designed for weight loss, is known as Wegovy. Mounjaro has not been reformulated for weight loss but, like Ozempic, it can also be used for this purpose.
Various clinical trials have demonstrated weight loss on Ozempic. The SUSTAIN trials found that over two years, people lost an average of 3.6 kg on the 0.5 mg dose of Ozempic and 4.9 kg on the 1 mg dose of Ozempic. At the higher dose of 1 mg, up to 66% of people lost more than 5% of their body weight compared to up to 11% of people on a placebo.
Mounjaro has been found to deliver even greater weight loss results. One study found that, within just one year, 42.3% of people taking tirzepatide (the active ingredient in Mounjaro) had lost at least 15% of their body weight compared to 19.3% of people taking semaglutide (Ozempic and Wegovy).
People taking tirzepatide were actually twice as likely to lose at least 10% of their body weight and three times as likely to lose 15% of their body weight than people on semaglutide. Therefore, Mounjaro is considered to be significantly more effective for weight loss than Ozempic, although head-to-head comparative trials have not yet been made.
Mounjaro vs Ozempic – Cost
Mounjaro is available on private prescription in the UK and costs start from £139 with Simple Online Pharmacy while Ozempic, which is not licensed for weight loss in the UK, costs approximately £200 a month.
While Mounjaro may seem expensive, it may also help you to achieve your weight loss goals more quickly. While research is still ongoing, initial results suggest that you need to continue these medications after achieving your ideal weight to avoid regaining the weight that you have lost.
Mounjaro vs Ozempic Side Effects
All medications carry a risk of side effects; Ozempic and Wegovy are no exception. Both drugs carry a risk of gastrointestinal side effects such as nausea, vomiting, diarrhoea, constipation, abdominal pain and other side effects. Common side effects of Ozempic also include hair loss, dizziness and headaches.
Alternative Treatments
If you are trying to lose weight, there are many different options available to you. These include other injectable weight loss medications, like Wegovy and Saxenda, as well as drugs like Xenical (orlistat) which help you to stop fat absorption in your intestines.
There are also a range of surgical options, such as a gastric sleeve. These procedures can deliver dramatic weight loss results in a short period of time. However, they are major operations that should not be undertaken lightly. For cosmetic purposes, some people may opt for liposuction, but the health benefits are not comparable to weight-loss surgery.
All weight loss interventions work best when made in conjunction with changes to diet and exercise. Diets that help to reduce your calorie intake, while maximising the nutritional value of the foods you consume, can help you lose weight. There are various local support groups that can help you to make these dietary changes.
Regular exercise is also a good way to lose weight. Not only does exercise help burn off energy, it also improves your metabolic rate, helping your body to burn off energy from food more efficiently.
Weight Loss Injections from £139 / Month
Conclusion
Mounjaro has been shown to deliver more weight loss more quickly than Ozempic. In that way, Mounjaro is the better treatment. As well as this, Mounjaro is currently available in the UK for weight loss, whereas Ozempic is not.
When considering weight loss treatment you should make sure to gain an understanding of what options are available to you and pick which will suit you best. Both Ozempic and Mounjaro have a similar side effect profile, but you may respond differently to each drug, so one may be a better fit than the other.
Key Takeaways
- Mounjaro and Ozempic are two different medications, with two different uses.
- Mounjaro (tirzepatide) can help you lose weight, while Ozempic (semaglutide) is designed for treating type 2 diabetes.
- Wegovy (semaglutide) is the branded version for weight loss.
- Mounjaro is available for weight loss with a prescription, while Ozempic is not available for weight loss in the UK.
- Patients looking to use Ozempic for weight loss should use Wegovy instead.
References
Diabetes UK (2024). What Is Ozempic? [online] Diabetes UK. Available at: https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/tablets-and-medication/glp-1/semaglutide/ozempic.
mounjaro.lilly.com. (n.d.). What is Mounjaro® for Adults with Type 2 Diabetes | Mounjaro® (tirzepatide). [online] Available at: https://mounjaro.lilly.com/what-is-mounjaro.
