• Orlistat 120mg Capsules Thumbnail
  • Orlistat Thumbnail

Orlistat 120mg Capsules

From £19.99

Medication features

  • The generic version of Xenical
  • Reduces the amount of fat the body absorbs
  • Ingredient in Alli Capsules
  • Take THREE times daily with meals
This medication is for patients who have a BMI over 30

NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you.


Buy Orlistat Online

You can buy Orlistat 120mg online with Simple Online Pharmacy. Orlistat (brand name, Xenical) is a weight loss aid which is available from our online doctor. You do not need a prescription, as our doctor can arrange this free of charge after you complete a consultation. 

Orlistat works in the same way as the over the counter medicine Alli. They contain the same active ingredient (Orlistat), however, the prescription version is twice the strength (120mg instead of 60mg). Orlistat 120mg tablets are the generic version of the better-known brand, Xenical. Because Xenical is no longer the only manufacturer of Orlistat, this has helped lower the price of the generic form of the drug. Orlistat works by decreasing the amount of fat the body absorbs. Combined with some good diet and exercise, this can help you achieve significant weight loss.

Once you have completed the online doctor consultation, our doctor will review your assessment and prescribe the selected medication if it is appropriate. Our pharmacy will then dispense and dispatch your prescription to your door. Before using Orlistat or Xenical, you should read the patient information leaflet.

Orlistat (Xenical) works by preventing around a third of the fat from the food you eat from being digested. The undigested fat is not absorbed and is passed out with your feces.

This helps you avoid gaining weight but does not necessarily cause you to lose weight. Therefore, it’s still important to stick to your recommended diet and exercise plan.

Orlistat (Xenical) is usually recommended if you have made a significant effort to lose weight through diet, exercise or changing your lifestyle.

Even then, orlistat is only prescribed if you have:

  • a body mass index (BMI) of 28 or more and other conditions related to weight, such as high blood pressure
  • a BMI of 30 or more

Treatment with Orlistat (Xenical) must be combined with a low-fat diet and other weight loss strategies, such as doing more exercise. Orlistat is not recommended for pregnant or breastfeeding women.



  • How Does Orlistat Work for Weight Loss?

    Orlistat works by binding to the enzymes in the body to prevent the absorption of fat. On average, Orlistat will work on around a quarter to one-third of the fat you eat. Instead of this fat being absorbed, it passes through your gut. For people with high-fat diets, this can result in oily stools.

  • Who can use Orlistat?

    Orlistat is indicated in people with a BMI over 30, or in people who have a BMI over 28, with another weight-related condition, such as diabetes or high blood pressure.

  • What is the difference between Orlistat and Xenical?

    Xenical is the branded version of the drug, Orlistat. Orlistat is the generic form of Xenical. Medically, they are exactly the same drug and contain exactly the same strength (120mg of Orlistat).

  • What is the difference between Orlistat / Xenical and Alli?

    Alli is an over the counter version of Orlistat, which is half the strength of the prescribed version. Alli contains 60mg of Orlistat, compared to 120mg in Xenical and generic prescription Orlistat.

  • What is the dosage and duration of treatment of Orlistat?

    One Orlistat capsule is taken with each main meal (to a maximum of three capsules daily). You can take the capsule before, during or up to one hour after each meal.

    If you miss a meal or the meal does not contain any fat, you may not need to take the orlistat capsule; check the patient information leaflet that comes with your medication.

    Treatment with Orlistat (Xenical) should only continue beyond three months if you have lost 5% of your body weight. It usually starts to affect how you digest fat within one to two days.

    If orlistat has not worked after three months, it is unlikely to be an effective treatment for you.

    If you have type 2 diabetes, it can take longer to lose weight using Orlistat (Xenical), so your target weight loss after three months may, therefore, be slightly lower.

    If Orlistat (Xenical) is successful after three months, your prescription may be continued for up to a year. After that, your GP will review your condition and decide whether you should continue with Orlistat (Xenical).

  • How effective is Orlistat?

    Orlistat helps reduce fat absorption by 25-33%. In trials, patients on Orlistat are twice as likely to lose over 10% of their body weight over the course of a year, in comparison to someone using diet alone. It should be noted, when taking Orlistat, diet and exercise are still key to achieving best results.

  • What can you eat when taking Orlistat?

    You should aim to reduce the fat in your diet when taking Orlistat, however, you can continue to eat normal foods.


Treatment Comparison

IngredientOrlistat 60mgOrlistat 120mgOrlistat 120mg
MechanismReduces fat absorptionReduces fat absorptionReduces fat absorption
DoseOne three times daily with mealsOne three times daily with mealsOne three times daily with meals

Side Effects

Side effects

Common side effects of Orlistat (Xenical)  can include:

  • fatty or oily stools
  • needing the toilet urgently
  • passing stools frequently
  • oily discharge from your rectum (you may have oily spots on your underwear)
  • flatulence (wind)
  • stomach pain
  • headaches

These side effects are much less likely to occur if you stick to a low-fat diet.

Women taking the oral contraceptive pill are advised to use an additional method of contraception, such as a condom if they experience severe diarrhoea while taking orlistat. This is because the contraceptive pill may not be absorbed by your body if you have diarrhoea, so it may not be effective.


Info Leaflet

Before taking any medication, it is important to read the Patient Information Leaflet. You can find information leaflets for your medicines by typing them into the search bar at medicines.org, or by contacting us.

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