Authored: 20/03/2025
UK Registered and Regulated
LegitScript Certified
UK Registered GPs
16,000+ Reviews
Rybelsus
Overview
Rybelsus is a once-daily oral tablet containing Semaglutide that helps suppress appetite and supports weight loss of around 10%.
- Once-daily tablet
- No injections required – taken orally
- Not currently licensed for weight loss in UK
Mounjaro is currently the latest generation GLP1 treatment available in the UK. This can help patients achieve 15-22.5% body weight loss.
Overview
Buy Rybelsus Weight Loss Tablets
Rybelsus is an effective weight-loss tablet designed to help you feel less hungry. It is taken orally once daily.
Rybelsus tablets are not licensed for weight loss in the UK. This is a prescription weight-loss medication, prescribed for type 2 diabetes.
They contains the active ingredient semaglutide, which is the same ingredient as the injectable weight loss medication "Wegovy".
Summary
| Dose | One tablet daily, following the dose-escalation schedule |
|---|---|
| Type of medicine | Appetite-suppressant - GLP-1 receptor agonist |
| Mechanism | Suppresses appetite, enhances satiety, reduces calorie intake |
| Active Ingredient | Semaglutide |
| Side Effects | Can include nausea, diarrhoea, constipation, abdominal pain, vomiting |
What Is Rybelsus?
Rybelsus is a prescription weight-loss tablet containing semaglutide. It helps weight loss by reducing appetite and calorie intake. It is suitable for adults with a body mass index (BMI) over 30 or a BMI over 27 with weight-related conditions such as high blood pressure or type 2 diabetes.
Rybelsus vs Wegovy
| Rybelsus | Wegovy | |
| Dose | One tablet DAILY | One injection WEEKLY |
| Administration | Oral Tablet | Subcutaneous Injection |
| Price per month | From £85 | From £139 |
| Effectiveness | ~10% body weight loss | ~15% body weight loss |
Rybelsus Price
Rybelsus prices start from £85 per month, depending on the strength. Monthly packs vary in price based on dosage:
- Rybelsus 3mg (Starter Dose): £85 per month
- Rybelsus 7mg: From £140 per month
- Rybelsus 14mg: From £170 per month
How to Take Rybelsus
Rybelsus tablets are taken once daily. The tablet should be swallowed whole with a sip of water on an empty stomach. Wait at least 30 minutes before eating, drinking, or taking other medication. The recommended dose is gradually increased to reduce side effects:
- Weeks 1-4: 3mg daily (starter dose)
- Weeks 5-8: Increase to 7mg daily
- Week 9 onwards: 14mg daily, if required
Is Rybelsus Effective for Weight Loss?
Clinical trials have shown Rybelsus significantly reduces body weight. In trials, patients achieved around 10% weight loss when combined with diet and exercise, compared to placebo.
However, at Simple Online Pharmacy, we do no prescribe Rybselsus as part of our weight loss service. Instead, we prescribe the licensed versions of this treatment, Wegovy and Mounjaro.
Contraindications & Drug Interactions
Rybelsus isn't suitable if you've had allergic reactions to semaglutide or its ingredients. It can cause digestive symptoms, increasing dehydration risk. Drink plenty of fluids.
People with diabetes shouldn't use Rybelsus as an insulin substitute. It may increase the risk of low blood sugar if combined with other diabetes medications.
Rybelsus and Pregnancy
Rybelsus should not be used during pregnancy or breastfeeding and should be discontinued at least 2 months before planning pregnancy.
Side Effects
Common side effects include nausea, vomiting, diarrhoea, constipation, abdominal pain, and fatigue. These usually improve over time. If side effects persist or are severe, seek medical advice.
Rybelsus Alternatives
Other options include injectable treatments like Mounjaro, Saxenda or Wegovy. Oral options include Orlistat.
Visit our weight loss clinic for more information.
Written by Qualified Experts
All of our medication and condition content is written by UK qualified pharmacists and doctors.
Reviewed: 22/04/2025
FAQ
General Information
What is Rybelsus?
Rybelsus is an oral tablet containing semaglutide, primarily licensed in the UK for treating type 2 diabetes. It is not currently licensed for weight loss.
How does Rybelsus work?
Rybelsus mimics the GLP-1 hormone, reducing appetite, slowing digestion, and promoting a feeling of fullness.
Is Rybelsus licensed for weight loss in the UK?
No. In the UK, Rybelsus is licensed only for type 2 diabetes treatment. For licensed weight loss treatments, consider Wegovy (semaglutide injection) or Mounjaro (tirzepatide).
Usage & Dosage
How is Rybelsus taken?
Rybelsus is taken once daily as an oral tablet on an empty stomach, at least 30 minutes before food or other medication.
What are typical dosages of Rybelsus?
Dosage begins at 3mg daily, increasing to 7mg after one month, and up to 14mg daily as required, based on clinician advice.
Effectiveness & Results
How effective is Rybelsus for weight loss?
Clinical trials suggest Rybelsus can achieve approximately 7–10% weight loss; however, it is not licensed specifically for weight management in the UK.
Side Effects & Safety
What are common side effects of Rybelsus?
Common side effects include nausea, vomiting, diarrhoea, constipation, stomach pain, and decreased appetite. These typically reduce over time.
Interactions
Can Rybelsus interact with other medications?
Yes, Rybelsus may interact with medications such as insulin or sulfonylureas, increasing the risk of hypoglycaemia.
Storage
How should Rybelsus tablets be stored?
Rybelsus tablets should be stored at room temperature, away from moisture and direct sunlight.
Access & Cost
Can I buy Rybelsus online in the UK for weight loss?
What licensed alternatives to Rybelsus are available for weight loss?
Licensed alternatives in the UK include Wegovy (semaglutide injection) and Mounjaro (tirzepatide), both available via our online doctor clinic after a consultation.
Compare
Treatment Comparison
| Saxenda | Xenical | Orlistat | Mysimba | |
| Ingredient | Liraglutide | Orlistat 120mg | Orlistat 120mg | Naltrexone/Bupropion |
| Mechanism | Regulates appetite | Reduces fat absorption | Reduces fat absorption | Regulates appetite |
| Dose | Injected once daily | One three times daily with meals | One three times daily with meals | Gradually increased to 4 tablets daily |
